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Instruction for use: Amitriptyline-Apo

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Dosage form: film coated tablets

Active substance: Amitriptyline*


N06AA09 Amitriptyline

Pharmacological group:


Composition and release form

Coated tablets.

amitriptyline 10 mg; 25 mg; 50 mg; 75 mg

in a blister of 10 pcs .; in a pack of cardboard 1, 2, 5 and 10 blisters or in polyethylene bottles of 100, 500 and 1000 pcs.

Pharmachologic effect

Mode of action - antidepressive, anxiolytic, sedative.

Dosing and Administration

Inside, during or after a meal. The initial daily dose is 50-75 mg (25 mg in 2-3 doses), then the dose is gradually increased by 25-50 mg until the desired antidepressant effect is achieved. The optimal daily therapeutic dose is 150-200 mg (the maximum part of the dose is taken at night). In severe depression, resistant to therapy, the dose is increased to 300 mg or more, up to the maximum tolerated. In these cases, it is advisable to start treatment with an intravenous or intravenous drug, while using higher initial doses, accelerating the build-up of dosages under the control of the somatic condition.

After obtaining a persistent antidepressant effect after 2-4 weeks, the doses gradually and slowly decrease. When there are signs of depression with lower doses, you need to return to the previous dose. If the patient's condition does not improve within 3-4 weeks of treatment, then further therapy is impractical.

In elderly patients with mild disorders, in outpatient practice, the doses are 25-50-100 mg (maximum) in divided doses or once a day at night.

Children: 6-12 years - 10-30 mg (1-5 mg / kg) per day in 2 divided doses, 12-18 years - 10 mg 3 times a day and 20 mg at bedtime; if necessary and taking into account the tolerability dose is increased to 100 mg / day in divided doses or once before bedtime.

For the prevention of migraine, with chronic pain of a neurogenic nature (including long-term headaches) - from 12.5-25 mg to 100 mg / day.

A comment

General distributor: "Sun Vanchers 95", Russia.

Storage conditions of the drug Amitriptyline-Apo

In a dry, the dark place at a temperature of no higher than 30 ° C.

Keep out of the reach of children.

Shelf life of the drug Amitriptyline-Apo

5 years.

Do not use after the expiry date printed on the package.

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