Instruction for use: Vero-Pipecuronium

Active substance: Pipecuronium bromide

ATX Code

M03AC06 Pipecuronium bromide

Pharmacological group

Miorelaxant nondepolarizing peripheral action [n-anticholinergics (muscle relaxants)]

Composition and form of release

Lyophilizate for the preparation of a solution for intravenous administration 1 vial.

Pipecuronium bromide 0.004 g

(In terms of 100% of the substance)

Auxiliary substances: mannitol

In vials, complete with a knife ampoule; In a pack of cardboard 1, 5, 10 or 25 sets or in a box of 50, 85 or 100 bottles (for hospitals).

pharmachologic effect

Pharmacological action - miorelaksiruyuschee, nedepolyarizuyuschee.

Dosing and Administration

In / in. Immediately before the administration of 4 mg (1 bottle) of lyophilized powder is diluted in 2 ml of water for injection or 0.9% solution of sodium chloride.

When calculating the dose of Vero-pipecuronium, the technique of anesthesia used, the possible interactions with drugs administered before or during anesthesia, the condition and sensitivity of the patient, age, sex, body weight, the functional state of the liver and kidneys should be considered.

The average single dose for adults is 70-80 mkg / kg, the maximum single dose is 100 mcg / kg. Repeated doses of the drug are administered at a rate of 10-15 μg / kg. When intubation with succinylcholine, the initial dose of Vero-pipecuronium is 40-50 μg / kg. In chronic renal insufficiency, the amount of the administered dose is determined by the values of the creatinine concentration: at a creatinine concentration of more than 100 ml / min - up to 100 μg / kg, at a creatinine concentration of 100 ml / min - 85 μg / kg; At a creatinine concentration of 80 ml / min - 70 μg / kg; At a creatinine concentration of 60 ml / min - 55 μg / kg; At a creatinine concentration of less than 40 ml / min - 50 μg / kg.

When using Vero-pipecuronium in recommended doses, the effective relaxation of skeletal muscles is maintained in adults for 50-70 minutes.

Doses in children under 3 months of age have not been determined; From 3 to 12 months - 40 mkg / kg (provides muscle relaxation lasting from 10 to 44 minutes); From 1 year to 14 years - 57 mkg / kg (muscle relaxation - from 18 to 52 min).

storage conditions

In a dry, the dark place at a temperature of 2-8 ° C.

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.