Instruction for use: Tropisetron

The Latin name of the substance Tropisetron

Tropisetronum (genus. Tropisetroni)

Chemical name

1alphaH, 5alphaH-Tropan-3alpha-indole-3-carboxylate

Gross Formula

C₁₇H₂₀N₂O₂

Pharmacological groups

Antiemetic means and preparations

Serotonergic agents

The nosological classification (ICD-10)

R11 Nausea and vomiting: Postoperative vomiting; Nausea; Vomiting; Vomiting in the postoperative period; Vomiting medication; Vomiting in the background of radiation therapy; Vomiting uncontrollable; Vomiting in radiation therapy; Persistent vomiting; Indomitable vomiting; Postoperative nausea; Vomiting with chemotherapy; Vomiting of the central genesis; Vomiting with cytotoxic chemotherapy; Persistent hiccups; Repeated vomiting

Y84.2 Abnormal reaction or late complication of the patient without mentioning accidental harm to him during the performance of the radiological procedure and radiation therapy: Radiation therapy of tumors

Z51.0 Radiotherapy course: Supplement to external radiation therapy; Local X-Ray Irradiation; Radiation therapy; Brain edema associated with radiation therapy; Lesion in radiation therapy; Radiotherapy

Z51.1 Chemotherapy for neoplasm: Cystitis hemorrhagic, caused by cytostatics; Urotoxicity of cytostatics

Z98.8 Other specified post-surgical conditions: Purulent complications in the postoperative period; Suppurative complications of surgery; Postoperative liver dysfunction; Postoperative vomiting; Postoperative complications; Postoperative period; Early postoperative period

CAS Code

89565-68-4

Pharmacology

Pharmacological action - Antiemetic.

Selectively blocks the presynaptic 5-HT3 receptors of peripheral neurons and the central nervous system, thereby inhibiting the gag reflex.

Fast (on average for 20 minutes) and almost completely (more than 95%) is absorbed from the digestive tract. After ingestion, Cmax is reached within 3 hours. Absolute bioavailability is dose dependent. Binding to plasma proteins - 71%. Undergoes biotransformation in the liver by hydroxylation followed by conjugation (glucuronides), while the metabolites formed are inactive. It is excreted slowly from the body. The duration of action is about 24 hours.

Application of substance Tropisetron

Nausea and vomiting during antitumor therapy (prophylaxis) and in the postoperative period (prevention and treatment).

Contraindications

Hypersensitivity, pregnancy, breast-feeding, children's age (up to 2 years).

Restrictions on the use

Arterial hypertension.

Side effects of the substance Tropisetron

Abdominal pain, constipation, diarrhea, headache, dizziness, weakness, allergic reactions; Extremely rare - fainting, collapse, cardiac arrest.

Interaction

Inducers of microsomal liver enzymes (phenobarbital, rifampicin) reduce the concentration in the blood.

Overdose

Symptoms: increased blood pressure, visual hallucinations.

Treatment: symptomatic.

Routes of administration

IV, inside.

Precautions for the substance Tropisetron

Care should be taken when prescribing against uncontrolled hypertension and to consider the possibility of reducing the reaction rate.