Instruction for use: Triiodthyronin 50 Berlin-Chemie

Active substanceLiothyronine

ATX codeH03AA02 Sodium Lithiotronin

Pharmacological group of substance Calcitonin

Thyroid agent [Thyroid and parathyroid hormones, their analogs and antagonists (including antithyroid agents) / 67 /]

Nosological classification (ICD-10)

E01 Thyroid gland diseases associated with iodine deficiency and similar conditions

Hormonal deficiency of the thyroid gland due to iodine deficiency in the body, Goiter endemic, Iodine deficiency alimentary state, Iodine deficiency disease, Iodine Deficiency, Endemic cretinism

E03.9 Unspecified hypothyroidism

Hypothyroidism, Hypothyroid conditions, Thyroid hypothyroidism, Diagnosis of hypothyroidism, Simple goiter, Hypothyroid edema,Wolf-Chaikoff effect, Congenital hypothyroidism, Secondary hypothyroidism, Hypothyroid obesity, Hypothyroid status, Obstructive hypothyroidism

E04.9 Non-toxic goiter, unspecified

The sporadic goiter, Non-toxic goiter

E05.9 Thyrotoxicosis, unspecified

tireotoksicski reaction, Enlargement of the thyroid gland with symptoms of hyperthyroidism, The phenomenon of iodine Basedow, Thyroid hyperplasia, hyperthyroid state, Hyperthyroidism, Thyroid dysfunction, Diffuse thyrotoxic goiter, The latent thyrotoxicosis, Increased thyroid function, thyrotoxicosis

Composition and form of production

Tablets 1 table.

Liothyronine 50 μg

Auxiliary substances: lactose; corn starch; gelatin; Magnesium stearate; Silicon dioxide colloid; Cochineal red A (Ponceau 4R)

In glass bottles of 60 pcs .; In a carton box 1 bottle.

Description of dosage form

Plane-cylindrical tablets of pink color, with one-sided risk.

Characteristic

Synthetic thyroid hormone.

pharmachologic effect

Pharmacological action - replenishing deficiency of thyroid hormones.

Increases the need for tissues in oxygen, stimulates their growth and differentiation, increases the level of basal metabolism (proteins, fats and carbohydrates). In small doses anabolic, and in large - catabolic effect. Inhibits the production of thyroid-stimulating hormone. Strengthens energy processes, positively affects the state of the nervous and cardiovascular systems, the liver and kidneys.

Pharmacodynamics

The maximum pharmacological effect develops in 2-3 days.

Pharmacokinetics

Absorption - 95% (within 4 hours). The latent period is 4-8 hours. Binding to plasma proteins is high. T1 / 2 - 2.5 days.

Indications

Hypothyroidism of any origin.

Treatment of hyperplasia of the thyroid gland: benign goiter with normal function, prevention of recurrence of goiter after surgery or after treatment with radioactive iodine.

As a part of combined therapy of toxic goiter with thyreostatic agents (after achieving drug exchange compensation).

Contraindications

Hypersensitivity, hyperthyroidism (exception: as part of combined therapy for thyreostatic treatment of thyroid hyperfunction after reaching the normal state of metabolism), IHD, myocardial infarction, angina pectoris, acute myocarditis, untreated adrenal insufficiency, diabetes mellitus, Addison's disease, cachexia.

pregnancy and lactation

It is not allowed to use Triiodothyronine 50 Berlin-Chemie during pregnancy as part of combination therapy in the treatment of thyroid hyperthyroidism in combination with thyreostatic drugs (drugs for the treatment of thyroid hyperfunction), since this can lead to the development of hypothyroidism in the fetus with all the ensuing from it Severe consequences.

Side effects

Hyperthyroidism: palpitations, arrhythmias, tachycardia, sweating, anxiety, irritability, weight loss, headache, dysmenorrhea, allergic reactions; Progression of heart failure, angina pectoris.

Interaction

Reduces the effect of hypoglycemic agents, enhances - indirect anticoagulants, vasoconstrictor drugs. Kolestyramin lowers absorption. Oral contraceptives lower the effect. Phenytoin, salicylates, dicoumarol, furosemide (in high doses), clofibrate, antidepressants, cardiac glycosides, ketamine increase the concentration and risk of side effects of Liothyronine.

Dosing and Administration

Inside, 30 minutes before meals. Adults, the initial dose - 0.5 table. Per day (corresponding to 25 μg of Liothyronine). This dose is advisable to increase every 2-4 weeks at 0.5-1 table. Usually the average maintenance dose is from 1 to 1.5 tablets.

Precautionary measures

With caution appoint elderly patients, with coronary artery disease (CHD), heart failure and certain forms of heart rhythm disturbances (tachyarrhythmias).

special instructions

Even light, thyrotonin-induced hyperthyroidism should be avoided, especially if there is insufficient blood supply to the heart (coronary insufficiency), with heart failure or with tachyarrhythmias. With hypothyroidism of the thyroid gland caused by pituitary damage, it is necessary to find out whether there is a concomitant failure of the adrenal cortex at the same time. In this case, her treatment should begin before the appointment of thyroid hormone therapy.

Storage conditions

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiry date printed on the package.