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Instruction for use: Timolol-MEZ

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Active substance Timolol

ATX Code S01ED01 Timolol

Pharmacotherapeutic group:


Ophthalmic agents

The nosological classification (ICD-10)

H40.0 Suspected glaucoma

Marked rise in intraocular pressure, Hypertension eyes, ocular hypertension, Measurement of intraocular pressure, ophthalmohypertension, Elevated IOP, Elevated intraocular pressure, Elevated intraocular pressure in infectious diseases of the eye, Povyshennore intraocular pressure, Increased ophthalmotonus, Spontaneous blockade angle opposite eye, Narrow chamber angle, Iatrogenic, blockade angle opposite eye

H40.1 Primary open-angle glaucoma

open-angle glaucoma, Open-angle glaucoma, Primary glaucoma, pseudoexfoliation glaucoma, Elevated IOP

H40.2 Primary angle-closure glaucoma

closure Glaucoma, Glaucoma with a narrow angle of anterior chamber, Angle-closure glaucoma, Acute angle-closure glaucoma, An acute attack of angle-closure glaucoma, Elevated intraocular pressure angle-closure glaucoma, Chronic angle-closure glaucoma

H40.3 Glaucoma secondary posttraumatic

Post-traumatic secondary glaucoma, Glaucoma after cataract operated

H40.4 Glaucoma secondary to inflammatory diseases of the eye

Glaucoma uveal, Uveal secondary glaucoma

H40.5 Glaucoma secondary to other eye diseases

The secondary open-angle glaucoma, Glaucoma afakicheskaya, Secondary glaucoma

H40.6 Glaucoma secondary, caused by taking drugs

Q15.0 Congenital glaucoma

Structure and Composition

1 ml of eyedrops contains timolol maleate 0.00342 or 0.00684 g; in vials to 5 ml with dropper cap, in a cardboard bundle one bottle or tube-looks at 1.3 ml, in a cardboard bundle 5 tubes.


Clear, colorless liquid.

pharmachologic effect


Blocks beta1- and beta2-adrenergic receptors. When instillation into the conjunctival sac lowers intraocular pressure by decreasing the formation of intraocular fluid and improve its drainage. It has no intrinsic sympathomimetic and membrane stabilizing activity.


Reducing the intraocular pressure begins within 20 min after instillation, the maximum effect is observed after 1-2 hours duration - 24 hours.


Chronic open-angle glaucoma, secondary glaucoma (uveal, afakicheskaya, posttraumatic), ocular hypertension, angle-closure glaucoma (in combination with miotikami), congenital glaucoma, the ineffectiveness of other therapeutic measures within the time necessary to prepare for the surgery.


Hypersensitivity to the drug, asthma, chronic obstructive bronchitis, sinus bradycardia (50 or less beats per minute), AV blockade II and III level, heart failure, cardiogenic shock, severe corneal dystrophy, rhinitis.

Pregnancy and breast-feeding

Not recommended.

Side effects

Local reactions: redness eyelid skin, burning and itchy eyes, watery eyes, photophobia, conjunctival hyperemia, intermittent swelling of the corneal epithelium; rarely - superficial punctate keratopathy (reduced corneal transparency), diplopia, ptosis, decreased corneal sensitivity.

Systemic reactions: bradycardia, bradyarrhythmia, decreased blood pressure, dizziness, nausea, headache, muscle weakness, insomnia, bronchospasm.


Compatible with all antiglaucoma drugs. Pilocarpine, epinephrine, acetazolamide potentiate the effect of the drug. With simultaneous use of beta-blockers in and timolol locally possible mutual reinforcement effects. The ingestion of calcium antagonists (corinfar et al.), Rauwolfia drugs increases the likelihood of severe hypotension, bradycardia. It enhances the effect of peripheral muscle relaxants (drug should be discontinued 48 hours prior to anesthesia).

Dosing and Administration

1 drop into the conjunctival sac of 1-2 times a day. With the lack of efficiency of 0.25% solution of switching to the use of 0.5% on the same lines of the solution. Monitoring the effectiveness is carried out not earlier than 1-2 weeks.

Treatment should be under regular control of intraocular pressure (at least 1 time per month), the field of vision and corneal (1 every 6 months).

Precautionary measures

Do not appoint premature babies.

Caution should be used in patients with labile course of diabetes.

special instructions

When using the vials should be boiled pipette 1 time per day.

Storage conditions

In the dark place at a temperature no higher than 25 C.

Keep out of the reach of children.

shelf life

2 years. After opening the bottle - 14 days.

Do not use beyond the expiration date printed on the package.

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