Instruction for use: Tauredon
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Dosage form: Injection for injection
Active substance: Natrii aurothiomalas
Pharmacological group:
Immunodepressants
The nosological classification (ICD-10)
M06.9 Rheumatoid arthritis, unspecified: Rheumatoid arthritis; Pain syndrome in rheumatic diseases; Pain in rheumatoid arthritis; Inflammation in rheumatoid arthritis; Degenerative forms of rheumatoid arthritis; Children's rheumatoid arthritis; Exacerbation of rheumatoid arthritis; Acute articular rheumatism; Rheumatic arthritis; Rheumatic polyarthritis; Rheumatoid arthritis; Rheumatic polyarthritis; Rheumatoid arthritis; Rheumatoid arthritis; Rheumatoid arthritis of active course; Rheumatoid periarthritis; Rheumatoid polyarthritis; Acute rheumatoid arthritis; Acute rheumatism
M07.3 Other psoriatic arthropathies (L40.5 +): Psoriatic arthritis; Generalized form of psoriatic arthritis; Psoriatic arthritis
M08 Juvenile [juvenile] arthritis: Juvenile arthritis; Juvenile chronic polyarthritis; Juvenile chronic arthritis; Juvenile rheumatoid arthritis; Arthritis Juvenile chronic
Composition and release form
1 ampoule with 0.5 ml solution for injection contains sodium aurothiomalate 10 (Tauredon 10), 20 (Tauredon 20) or 50 (Tauredon 50) mg; In the package 1 or 10 pcs.
Pharmachologic effect
Mode of action - Anti-inflammatory, immunosuppressive.
Indication of the drug Tauredon
Rheumatoid arthritis, juvenile rheumatoid arthritis, psoriatic arthritis.
Contraindications
Hypersensitivity, polyvalent allergy, anemia, pancytopenia, renal dysfunction, severe liver damage, active form of pulmonary tuberculosis, collagenosis (systemic lupus erythematosus, nodular periarteritis, scleroderma, dermatomyositis), ulcerative colitis, complicated forms of diabetes mellitus, pregnancy, breast-feeding.
Side effects
During active therapy: tachyarrhythmia, ECG changes in the type of myocardial ischemia, skin rash, headache, fever, lowering blood pressure, nausea, abdominal pain. During maintenance therapy: stomatitis, alopecia, proteinuria (rarely nephrotic syndrome), liver dysfunction, cholestasis, hematopoiesis disorders (thrombocytopenia, leukopenia, anemia), photosensitivity, dermatitis, pruritus..
Interaction
Other antirheumatic drugs increase the likelihood of side effects.
Dosing and Administration
Deep IM. Saturation period: 2 injections per week, 1 to 3 injections administered 10 mg (Tauredon 10), 4 to 6 injections - 20 mg (Tauredon 20), with 7 injections - either 2 times a week for 50 mg (Tauredon 50), or once a week, 100 mg (2 ampoules of Tauredon 50). This dose should be maintained until the clinical effect is achieved, but not exceeding the total dose of 1600 mg (maximum 2000 mg). The period of maintenance therapy: 100 mg of the drug once a month or 50 mg once every 2 weeks. This treatment can last for months and years. Children are prescribed 0.7-1 mg / kg per week until the saturation phase is reached. In the phase of maintenance therapy, the drug is administered at a dose of 1 mg / kg 1-2 times per month.
Precautionary measures
It is not recommended to be used in combination with aminoquinolines, d-penicillamine, small immunosuppressants, sulfasalazine.
Storage conditions of the drug Tauredon
In a dry, cool place protected from light.
Keep out of the reach of children.
Shelf life of the drug Tauredon
3 years.
Do not use after the expiry date printed on the package.