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Instruction for use: Synphase

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ATX code G03AA10 Gestodene + ethinylestradiol

Pharmacological group

Estrogens, gestagens; Their homologues and antagonists

Nosological classification (ICD-10)

Z30 Monitoring contraceptive use

Local Contraception, Contraception oral, Local contraception, Episodic prevention of pregnancy, Hormonal Contraception, Contraception, Prevention of Pregnancy, Prevention of unwanted pregnancy, Contraceptive intrauterine, Contraception in women with androgenization phenomena, Installation and removal of the intrauterine device, Prevention of pregnancy (contraception)

Z30.0 General advice and advice on contraception

Safe sex, Intrauterine device contraception, Contraception, Contraceptive intrauterine, Oral contraception, Oral contraception during lactation and with estrogen contraindications, Postcoital contraception, Prevention of Pregnancy, Prevention of unwanted pregnancy, Emergency Contraception, Episodic prevention of pregnancy, Contraception in adolescents, Prevention of pregnancy (contraception)

Composition and form of release

1 white tablet contains norethisterone 1 mg and ethinyl estradiol 35 μg, 1 blue tablet - norethisterone 0.5 mg and ethinylestradiol 35 μg, 1 orange placebo tablet - lactose monohydrate, magnesium stearate, microcrystalline cellulose, anhydrous lactose; In the blister is 21 pcs. (9 white and 12 blue) or 28 pcs. (9 white, 12 blue and 7 orange), in the box there is 1 blister.

pharmachologic effect

The pharmacological action is estrogen-gestagenic, contraceptive.

It inhibits ovulation, increases the production of cervical mucus, which reduces the mobility of spermatozoa, disrupts the egg's ability to implant due to changes in the endometrium.




- Thrombophlebitis, thromboembolic complications, cerebral circulation disorders, IHD, myocardial infarction, hyperlipidemia.

- Acute or chronic liver disease, incl. The Dubin - Johnson syndrome.

- Idiopathic jaundice, itching or pemphigoid during pregnancy.

- Cancer of the breast or genitals.

- Estrogen dependent neoplasia.

- Atypical uterine bleeding of unknown origin.

- Migraine in the anamnesis is classical, localized or amplifying ("crescendo").

pregnancy and lactation

Contraindicated during pregnancy and lactation.

Side effects

Dyspeptic phenomena, changes in appetite, nausea, weight gain, breast engorgement, changes in libido, headache, growth of existing uterine fibroid, depression, changes in carbohydrate, fat and other metabolic forms, spotting or bleeding in the first few cycles.


Antibiotics, sedatives, antiepileptic, anti-inflammatory drugs reduce the effectiveness of Synphase.

Dosing and Administration

Inside, preferably at the same time, 1 tablet / day, starting from the 1st day of the menstrual cycle, for 21 days (if it is impossible to take from 1 day of the menstrual cycle, take the first tablet from the 1st to the 5th day menses). After a 7-day break, a new course begins.

special instructions

The contraceptive effect develops from the first day of admission (if the first pill was taken on the first day of the cycle). If another procedure is missed, you should take the pill no later than 12 hours, even if it takes 2 tablets / day.

storage Conditions

In dry, the dark place at a temperature of no higher than 25 C.

Keep out of the reach of children.

Shelf life

5 years.

Do not use after the expiry date printed on the package.

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