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Dorzopt (Dorsopt) eye drops - a drug for the treatment of glaucoma, which reduces the increased intraocular pressure. Refers to inhibitors of carbonic anhydrase. Does not cause a narrowing of the pupil, spasm of accommodation, visual disturbances in bright light.
Dorzopt eye drops - antiglaucoma preparation, a local inhibitor of carbonic anhydrase. Reduces the secretion of the aqueous humor, slowing the formation of bicarbonate, followed by a weakening of the transfer of sodium and water. Does not cause a spasm of accommodation, miosis, gemeralopia.
It penetrates the eye mainly through the cornea (to a lesser extent through the sclera or limbus). Systemic absorption is low. After entering the blood quickly penetrates into the red blood cells containing a significant amount of carbonic anhydrase II.
Distribution and Metabolism
Binding to plasma proteins - 33%. It is transformed into an N-desethylated metabolite, less active with respect to carbonic anhydrase II, but capable of blocking carbonic anhydrase I. For long-term use, it accumulates in red blood cells.
It is excreted by the kidneys in the unmodified form and in the form of metabolites. After cancellation, the rapid phase of withdrawal is replaced by a slow one, caused by the gradual release of the drug from erythrocytes, with T1 / 2 about 4 months.
With caution: prescribe the drug for diabetes, liver failure, corneal diseases, use in patients after antiglaukomatoznyh operations (risk of eye hypotension, retinal detachment).
The preservative of benzalkonium chloride contained in the preparation can be adsorbed by soft contact lenses, causing eye irritation and toxic effects. The drug is used only after removal of contact lenses. To establish contact lenses should be no earlier than 15 minutes after instillation.
It is necessary to control the content of potassium, electrolytes in the blood serum and its pH.
In elderly patients, sensitivity to dorsolimide may increase, so this category of patients may require a dose reduction.
Impact on the ability to drive vehicles and other mechanisms that require increased concentration
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Bury 1 drop in the conjunctival sac of the affected eye 3 times / day. In combination with beta-blockers for topical administration - 1 drop 2 times / day. If several local ophthalmic preparations are used in the treatment, they are administered at an interval of 10 minutes.
Important notice- the outer box design may vary before prior notice!
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