Instruction for use: Syncumar

Dosage form: tablets

Active substance: Acenocoumarolum

ATX

B01AA07 Acenocumarol

Pharmacological groups

Anticoagulants

The nosological classification (ICD-10)

I74 Embolism and arterial thrombosis: Thrombosis of effort (stress); Arterial thrombosis; Arteriothrombosis; Subacute and chronic arterial thrombosis; Subacute thrombosis of peripheral arteries; Postoperative thrombosis; Vascular thrombosis; Vascular embolism; Thrombosis of aortocoronary shunt; Arterial thrombosis; Thrombosis of arteries; Coronary artery thrombosis; Coronary thrombosis; Thrombosis of blood vessels; Thrombosis with ischemic stroke; Thrombosis with general surgical operations; Thrombosis in Oncology Operations; Vascular thrombosis; Thrombus formation in the postoperative period; Thrombotic complications; Thromboembolic diseases; Thromboembolic syndrome; Thromboembolic complication in the postoperative period; Thromboembolism of arteries; Partial vascular thrombosis; Embolism; Embolism of arteries

I82 Embolism and thrombosis of other veins: Recurrent venous thrombosis; Postoperative thrombosis; Venous thrombosis; Acute venous thromboembolism; Recurrent vein thrombosis; Venous thrombosis; Thrombosis of veins of internal organs; Venous thrombosis; Deep vein thrombosis; Thrombosis of blood vessels; Vascular thrombosis; Thrombosis of veins; Deep vein thrombosis; Thromboembolic diseases; Thromboembolism of veins; Severe venous thrombosis; Embolism; Embolism of veins; Thromboembolic complications

Composition and release form

1 tablet contains acenocoumarol 2 mg; In the packaging of a contiguous cell 10 tablets, in a cardboard box 5 packs.

Pharmachologic effect

Mode of action - Anticoagulant.

It blocks K-vitamin-reductase and stops the activation of vitamin K.

Pharmacokinetics

Violates the synthesis of prothrombin and other vitamin K-dependent clotting factors (VII, IX, X).

Indications for Syncumar

Thrombosis and embolism (prevention).

Contraindications

Hemophilia, renal failure, severe liver dysfunction, hypertension, gastrointestinal ulcer, hypovitaminosis K, heart aneurysm, condition after neurosurgical operations, pregnancy.

Side effects

Bleeding, rarely - agranulocytosis, temporary hair loss, skin necrosis, skin rash.

Interaction

NSAID, sulfonamides, some antibiotics, local anesthetics strengthen; Barbiturates, diuretics, contraceptives, digitalis preparations weaken the effect.

Dosing and Administration

Inside, the dose and duration of treatment are set individually.

Precautions measures

Treatment is carried out under constant supervision, it is necessary to carefully monitor the overall condition of the patient and changes in the blood coagulation system.

Storage conditions of the drug Syncumar

At a temperature not exceeding 30 ° C. And humidity below 70%.

Keep out of the reach of children.

The shelf life of the drug Syncumar

5 years.

Do not use beyond the expiration date printed on the package.