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Instruction for use: Sulodexide

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Trade name of the drug Angioflux, Vessel Due F

The Latin name of the substance Sulodexide

Sulodexidum (genus. Sulodexidi)

Chemical name

Glucurono-2-amino-2-deoxyglucoglucan sulfate

Pharmacological group:


Nosological classification (ICD-10)

I74 Embolism and arterial thrombosis: Thrombosis of effort (stress); Arterial thrombosis; Arteriothrombosis; Subacute and chronic arterial thrombosis; Subacute thrombosis of peripheral arteries; Postoperative thrombosis; Vascular thrombosis; Vascular embolism; Thrombosis of aortocoronary shunt; Arterial thrombosis; Thrombosis of arteries; Coronary artery thrombosis; Coronary thrombosis; Thrombosis of blood vessels; Thrombosis with ischemic stroke; Thrombosis with general surgical operations; Thrombosis in Oncology Operations; Vascular thrombosis; Thrombus formation in the postoperative period; Thrombotic complications; Thromboembolic diseases; Thromboembolic syndrome; Thromboembolic complication in the postoperative period; Thromboembolism of arteries; Partial vascular thrombosis; Embolism; Embolism of arteries

I79.2 Peripheral angiopathy in diseases classified elsewhere: diabetic angiopathy; Angiopathy in diabetes; arteriosclerosis diabetic; Pain in lesions of peripheral nerves; Diabetic angiopathy; Diabetic microangiopathy; Diabetic vascular disease; Intermittent angioneurotic disbaziya; Macroangiopathy in diabetes; microangiopathy; Microangiopathy in diabetes mellitus; Tingling sensations in the hands and feet; Coldness in the extremities; Peripheral angiopathy; Peripheral arterial disease; Sclerosis Menkeberga; Chronic obliterating diseases of arteries

I80 Phlebitis and thrombophlebitis: Diseases of peripheral vessels; Inflammation of superficial veins; Inflammatory diseases of veins; Deep venous thrombophlebitis; The disease of veins; Disease of the veins of the lower extremities; Diseases of peripheral vessels; Migrating phlebitis; Insufficiency of veins of lower extremities; Exacerbation of chronic thrombophlebitis; Acute thrombophlebitis; Acute thrombophlebitis of superficial veins; Periphlebitis; Periflebit surface; Superficial inflammation of veins; Surface thrombophlebitis; Surface phlebitis; Thrombophlebitis; Deep vein thrombophlebitis; Thrombophlebitis superficial; Phlebitis; Phlebitis of deep veins; Phlebitis of superficial veins; Phlebopathy; Chronic thrombophlebitis; Endophlebitis

CAS code


Characteristics of the substance Sulodexide

Extract from the mucosa of the small intestine of pigs. Contains 80% of heparinoid (fast-moving fraction) and 20% of dermatan sulfate.


Mode action - fibrinolytic, angioprotective, lipid-lowering, anticoagulant, antiadhesive, antithrombotic.

Suppresses the activity of factor Xa, enhances the synthesis of prostacyclin. Reduces the level of fibrinogen in the blood plasma and stimulates the fibrinolytic system: increases the level of the tissue activator of plasminogen, reduces the content of its inhibitor in the blood. Angioprotection is due to the restoration of structural integrity and function of endothelial cells, the normal density of the negative charge of the pores of the basal membrane of the endothelium. Normalizes the rheological properties of blood, reduces its viscosity, suppresses the proliferation of mesangium cells, reduces the thickness of the basal membrane.

Application of the substance Sulodexide

Angiopathy with an increased risk of thrombosis (including micro- and macroangiopathy in diabetes mellitus).


Hypersensitivity, hemorrhagic diathesis, diseases associated with an increased risk of bleeding.

Side effects of Sulodexide

Dyspeptic phenomena (including nausea, vomiting), epigastric pain, allergic reactions; At the injection site - pain, burning, bruising.


It is not recommended simultaneous use with drugs that affect the system of hemostasis (direct and indirect anticoagulants, antiaggregants).


Symptoms: bleeding or bleeding.

Treatment: maintenance of vital functions (against drug withdrawal).

Routes of administration

Inside (between meals), IM or IV.

Precautions for the substance Sulodexide

Before the start of treatment, a coagulogram should be made. Use with caution in pregnancy and lactation (safety and efficacy not determined).

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