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Instruction for use: Nativa

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ATX Code H01BA02 Desmopressin

Active substance: Desmopressin

Pharmacological group

Treatment for diabetes insipidus [Hypothalamus, pituitary, gonadotropins and their antagonists]

Nosological classification (ICD-10)

E23.2 Non-diabetes mellitus

Diabetes insipidus, Non-sugar, Renal form of diabetes insipidus, Non-hypophyseal diabetes pituitary (central)

N39.4 Other specified types of urinary incontinence

Urinary incontinence, Bed-wetting, Frequent nocturnal urination, Urinary incontinence in women, Anishuriya, Primary nocturnal enuresis, Primary nocturnal enuresis in children

R35 Polyuria

Pollakuria, Night pollakiuria, Pollakiuria and nocturia, Night polyuria, Acute polyuria


Tablets 1 table.

active substance:

Desmopressin acetate 0.1 mg\ 0.2 mg

(In terms of desmopressin: 0.089 mg / 0.178 mg)

Auxiliary substances: lactose monohydrate - 10/10 mg; Crospovidone XL - 5/5 mg; Magnesium stearate - 2/2 mg; Lupus - up to 200/200 mg (lactose monohydrate - 170.1 / 170 mg, crospovidone - 6.4 / 6.4 mg, povidone - 6.4 / 6.4 mg)

pharmachologic effect

Pharmacological action - vasopressin-like, antidiuretic.

Dosing and Administration

Inside. Optimal dose of the drug is selected individually.

The drug should be taken some time after eating, since eating can affect the absorption of the drug and its effectiveness.

Central diabetes insipidus: the recommended initial dose for children over 4 years and adults is 0.1 mg 1-3 times a day. In the subsequent dose is selected depending on the response to treatment. Usually the daily dose is from 0.2 to 1.2 mg. For most patients, the optimal maintenance dose is 0.1-0.2 mg 1-3 times a day.

Primary nighttime enuresis: The recommended initial dose for children over 5 years and adults is 0.2 mg per night. In the absence of effect, the dose may be increased to 0.4 mg. The recommended course of continuous treatment is 3 months. The decision to continue treatment should be made on the basis of clinical data that will be observed after drug withdrawal within 1 week. It is necessary to monitor compliance with the restriction of fluid intake in the evening.

Nocturnal polyuria in adults: the recommended initial dose is 0.1 mg per night. If there is no effect within 7 days, the dose is increased to 0.2 mg and then to 0.4 mg (the frequency of dose increase is no more than 1 time per week). Remember the danger of fluid retention in the body. If after 4 weeks of treatment and dose adjustments adequate clinical effect is not observed, continue to use the drug is not recommended.

Form of issue

Tablets, 0.1 mg; 0.2 mg. For 30 tablets. In polymer bottles, with plastic lids with a dehumidifier. On 1 fl. In a cardboard box.

Terms of leave from pharmacies

On prescription.

storage conditions

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.

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