Instruction for use: Somatostatin (Somatostatinum)

Chemical name

L-Alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L- Cysteine cyclic (1 "14) disulphide

Pharmacological group

Hormones of the hypothalamus, pituitary gland, gonadotropins and their antagonists

Nosological classification (ICD-10)

E14.0 Diabetic coma hyperglycemic

Ketoacidosis is diabetic, Coma diabetic, Hyperglycaemic coma, Diabetic coma, Coma hyperosmolar non-ketoacidotic, Coma lactobacillus diabetic, Diabetic acidosis, Neketosis hyperglycemic hyperosmolar coma

K92.2 Gastro-intestinal bleeding, unspecified

Gastric and intestinal bleeding, Acute bleeding from the upper gastrointestinal tract, gastrorrhagia, Gastrointestinal bleeding, Intraoperative abdominal bleeding, enterorrhagia, Bleeding in the upper digestive tract, Gastrointestinal bleeding, Bleeding from the upper gastrointestinal tract, Bleeding from the gastrointestinal tract, Intraoperative bleeding abdominal, Recurrent bleeding in the digestive tract, Diagnosis of bleeding from the small intestine, peptic ulcer bleeding, Mallory-Weiss syndrome, Recurrent bleeding from peptic ulcers, Bleeding stomach

Z100 * CLASS XXII Surgical practice

Abdominal surgery, adenomectomy, Amputation, Coronary angioplasty, Angioplasty of the carotid arteries, Antiseptic skin treatment for wounds, Antiseptic Hand, Appendectomy, atherectomy, Balloon coronary angioplasty, Vaginal hysterectomy, The coronary bypass, Interventions in the vagina and cervix, Interventions on the bladder, Intervention in the mouth, Restoration and reconstructive surgery, Hand hygiene of medical personnel, Gynecologic surgery, Gynecological intervention, Gynecological surgery, Hypovolemic shock during operations, Disinfection of purulent wounds, Disinfection of wounds edges, Diagnostic intervention, Diagnostic procedures, Cervical Diathermocoagulation, Long-surgery, Replacing the fistula catheters, Infection in orthopedic surgery, Artificial heart valve, cystectomy, Short-term outpatient surgery, Short-term operation, Short surgical procedures, Krikotireotomiya, Blood loss during surgery, Bleeding during surgery and in the postoperative period, Kuldotsentez, laser photocoagulation, laser coagulation, retinal laser coagulation, Laparoscopy, Laparoscopy in Gynecology, CSF fistula, Small gynecological operations, Small surgical procedures, Mastectomy and subsequent plastic, mediastinotomy, Microsurgical operations on the ear, Mukogingivalnye operation, suturing, Minor surgery, neurosurgical operation, Immobilization of the eyeball in ophthalmic surgery, testectomy, pancreatectomy, Perikardektomiya, The period of rehabilitation after surgery, The period of, convalescence after surgery, Percutaneous transluminal coronary angioplasty, Pleural thoracentesis, Pneumonia postoperative and posttraumatic, Preparation for surgical procedures, Preparation for surgery, Preparation of the surgeon's hands before surgery, Preparation of the colon for surgical procedures, Postoperative aspiration pneumonia in neurosurgical and thoracic surgery, Postoperative nausea, Postoperative bleeding, postoperative granuloma, postoperative shock, The early postoperative period, myocardial revascularization, Radiectomy, gastric Resection, bowel resection, uterine Resection, liver Resection, enterectomy, Resection of part of the stomach, Reocclusion of the operated vessel, Bonding tissues during surgical procedures, Removal of sutures, Condition after eye surgery, Condition after surgery, Condition after surgery in the nasal cavity, Condition after gastrectomy, Status after resection of the small intestine, Condition after tonsillectomy, Condition after removal of the duodenum, Condition after phlebectomy, Vascular surgery, Splenectomy, Sterilization of surgical instruments, Sterilization of surgical instruments, sternotomy, Dental surgery, Dental intervention in periodontal tissues, strumectomy, Tonsillectomy, Thoracic surgery, total gastrectomy, Transdermal intravascular coronary angioplasty, Transurethral resection, Turbinektomiya, Removal of a tooth, cataract surgery, Removal of cysts, tonsillectomy, Removal of fibroids, Removing the mobile primary teeth, Removing polyps, Removing broken tooth, Removal of the uterus body, Removal of sutures, Urethrotomy, Fistula likvoroprovodyaschih ways, Frontoetmoidogaymorotomiya, Surgical infection, Surgical treatment of chronic limb ulcersm, Surgery, The surgery in the anal area, The surgery on the colon, Surgical practice, The surgical procedure, Surgical interventions, Surgery on the gastrointestinal tract, Surgical procedures on the urinary tract, Surgical procedures on the urinary system, Surgical intervention of the genitourinary system, Surgical procedures on the heart, Surgical manipulation, surgery, Surgery on the veins, Surgical intervention, Vascular surgery, Surgical treatment of thrombosis, cholecystectomy, Partial gastric resection, transabdominal hysterectomy, Percutaneous transluminal coronary angioplasty, Percutaneous transluminal angioplasty, Coronary artery bypass, tooth Extirpation, Extirpation of milk teeth, pulpectomy, pulsative cardiopulmonary bypass, tooth Extraction, teeth Extraction, cataract extraction, Electrocoagulation, endourological intervention, episiotomy, Etmoidotomiya, Complications after tooth extraction

Code CAS38916-34-6

Pharmacology

The pharmacological action is somatostatin-like.

Prevents the release of growth hormone. When IV injection in the blood plasma is subjected to enzymatic cleavage under the action of amino and endopeptidases. T1 / 2 - 2-3 minutes. Numerous effects are due to the binding of the corresponding receptors of target tissues. Reduces the amount of blood flow in the internal organs, without causing significant fluctuations in systemic blood pressure. It inhibits the release of gastrin, gastric juice, pepsin, reduces endo- (including glucagon) and exosecretion of the pancreas. It weakens the peristalsis of the stomach and intestines. Helps stop bleeding from the upper gastrointestinal tract (stomach, duodenum, varicose veins of the esophagus) due to a significant decrease in blood flow in the celiac arteries. Effective for the prevention of complications after surgery on the pancreas, in the treatment of bile and intestinal fistula.

Indications

Acute bleeding from the upper gastrointestinal tract (including varicose veins of the esophagus), pancreatic fistulas, bile and intestinal fistulas (auxiliary treatment), diabetic ketoacidosis (additional therapy), prevention of postoperative complications in surgical operations on the pancreas.

Contraindications

Hypersensitivity, pregnancy, early postpartum period, breast-feeding.

Side effects

Dizziness, a sensation of blood flushes to the face (very rarely), bradycardia, nausea and vomiting (only at a rate of administration of more than 50 μg / min).

Interaction

Increases the effect of histamine H2-blockers (decreased secretion of hydrochloric acid), hexobarbital and pentetrazole (acceleration of falling asleep and lengthening of sleep). Pharmaceutically incompatible (in one syringe) with other medications.

Routes of administration

In / in (intravenously).

Precautions

At the beginning of treatment, temporary hyper- or hypoglycemia may develop (blocking the secretion of insulin and glucagon), and therefore the blood glucose should be monitored every 3-4 hours, especially in diabetic patients. Repeated courses should be avoided (sensitization possible).