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DR. DOPING

Instructions

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Instruction for use: Protirelin (Protirelinum)

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Chemical name

5-Oxo-L-prolyl-L-histidyl-L-prolinamide

Pharmacological group

Hormones of the hypothalamus, pituitary gland, gonadotropins and their antagonists

Nosological classification (ICD-10)

E91 * Diagnosis of endocrine system diseases

Diagnosis of hypogalactia, Diagnosis of thyroid suppression, Diagnostic test of thyroid function, Diagnosis of hypothyroidism, Diagnosis of disorders of gonadotropic pituitary gland function, Thyroid scintigraphy test, Diagnostics of pheochromocytoma

Code CAS24305-27-9

Characteristics

White or white with a yellow hue amorphous powder. Soluble in water and alcohol.

Pharmacology

Pharmacological action is diagnostic.

The releasing factor, which is produced in the hypothalamus, which, acting on the anterior part of the pituitary gland, promotes the release of thyroid-stimulating hormone (TSH) and increases the concentration of prolactin. These properties make it possible to use it in the diagnosis of pituitary insufficiency in patients with hypothyroid conditions and in women with hypo- and agalactia, Gives the possibility of determining the pituitary reserve of prolactin. After intravenous administration of the drug, the peak of stimulated TSH concentration is observed after 20-30 minutes and returns to the baseline level after 2-3 hours. T1 / 2 is short and is 5 minutes.

Indications

Diagnosis of pituitary insufficiency in patients with hypothyroid conditions, diagnosis of hypo- and agalactia in women.

Contraindications

Hypersensitivity, organic lesion of the central nervous system, epilepsy.

Restrictions for use

Pregnancy.

Side effects AD fluctuations, headache, blindness, photophobia, anxiety, sweating, a sensation of a coma in the throat, a feeling of contraction in the chest, apoplexy of the pituitary gland, abdominal pain, xerostomia, unpleasant taste in the mouth, allergic reactions; Redness and tenderness at the injection site.

Routes of administration

In / in (intravenously).

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