Instruction for use: Serum antitetanicum equinum purificatum concentratum liquidum

Dosage form: Solution for intramuscular and subcutaneous administration

ATX

J06AA02 Tetanus toxoid

Pharmacological group:

Vaccines, serums, phages and toxoids

The nosological classification (ICD-10)

A35 Other forms of tetanus: Tetanus local; Tetanus; Muscle spasms in tetanus; Clostridiosis wound; Tetanus; Hydrophobia (hydrophobia)

Composition and release form

1 ampoule of 2, 3 or 5 ml of the drug for emergency tetanus prophylaxis contains one prophylactic dose (3000 IU) of tetanus antitoxin activity; 1 ampoule of 10 or 20 ml of the drug for the treatment of tetanus - 10,000, 20,000 or 50,000 IU. Preservative - chloroform (in the finished product is not determined); The content of sodium chloride is up to 0.9%. In the package 5 ampoules of serum (blue marking) and 5 ampoules of 1 ml of serum diluted 1: 100 - to determine the sensitivity of a person to a foreign protein.

Characteristic

Containing a specific immunoglobulin protein fraction of blood serum of horses, hyperimmunized by tetanus toxoid or toxin, purified and concentrated by peptic digestion. It is a clear or slightly opalescent colorless or yellowish liquid with no precipitate.

Pharmachologic effect

Mode of action - Detoxification.

Neutralizes tetanus toxins.

Indication of the drug Serum antitetanicum equinum purificatum concentratum liquidum

Tetanus (treatment and emergency prophylaxis).

Contraindications

For use with a therapeutic purpose, there are no contraindications. For use with the purpose of emergency prevention: hypersensitivity, pregnancy.

Side effects

Allergic reactions: fever, itching, rash, arthralgia, anaphylactic shock.

Dosing and Administration

IV, in the spinal canal (at the earliest possible date from the onset of the disease) at a dose of 10,000-20,000 IU. SC (for emergency prevention) in a dose of 3000 IU.

Precaution measures

Before the introduction of serum, it is necessary to prepare anti-shock therapy. The drug is not suitable for use in ampoules with broken integrity or lack of marking, with a change in physical properties (color, transparency, presence of unbreakable flakes), expired shelf life, improper storage.

Storage conditions of the drug Serum antitetanicum equinum purificatum concentratum liquidum

In a dry, the dark place at a temperature of 2-8 ° C.

Keep out of the reach of children.

Shelf life of the drug Serum antitetanicum equinum purificatum concentratum liquidum

3 years.

Do not use after the expiry date printed on the package.