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Instruction for use: Selang

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Trade name of the drug Selang

International name of the drug: threonyl-lysyl-arginyl-prolyl-prolyl-glycyl-proline-diacetate.

Dosage Form: nasal drops

Selank in terms of 100% substance - 1.5 mg (threonyl-lysyl-prolyl-arginyl-glycyl-prolyl-proline diacetate)
methyl parahydroxybenzoate (nipagina) - 1 mg
purified water - up to 1 ml.

Colorless transparent liquid.
Pharmacotherapeutic group:

antianxiety drug (tranquilizer).

ATX Code N05BX.
Pharmacological Properties

Selang - a synthetic peptide analogue of the endogenous tafttsina has neurospecific original mechanism of action on the central nervous system and binds to specific receptors on the membranes of nerve cells.

It has impact on the exchange of monoamines in the emotional structures of the brain (hypothalamus, diencephalon, the neocortex) and the activity of the brain enzyme tyrosine and tryptophan hydroxylase. It shows tropism to serotonergic system, normalizing the level of brain serotonin in the experimental conditions caused its decline. Selang stabilizes the processes of excitation and inhibition in the brain and increases the resistance of neurons in the cerebral cortex to the functional load of high intensity.

The pharmacological action of the drug spectrum dominated anxiolytic (anti-anxiety) effects by stimulating (activating) component. The drug does not possess gipnosedativny and muscle relaxant properties. Positive effect on the mnemic and cognitive functions of the brain, including in their violation. Activates the processes of learning, memory, analysis and reproduction of information, improves parameters of attention and short-term memory. Improves stability and motivational value of adaptive behavior. Selang has Wegetotropona effect, improves vegetative maintenance of activity in conditions of emotional stress has an impact on optimizing adaptive reserve of the body. Selang not detect unwanted side and toxic effect at 200-300-fold increase in dose as compared to ED50. It has embryotoxic, teratogenic, allergenic, local irritating action does not detect the mutagenic properties. In preparation No adverse long-term effects. Selang does not cause drug dependence phenomena.


Selang absolute bioavailability when administered intranasally is 92.8%. The drug is rapidly absorbed from the nasal mucosa and after 30 seconds, detected in blood plasma. plasma concentration decreases progressively during 5-5.5 minutes. Metabolites by intranasal route of administration is not detected. It penetrates into the brain tissue. The drug is rapidly distributed to organs and tissues, it is found in unchanged form in a well-vascularized organs (liver, kidney, heart). The daily urine is not determined by any of unchanged drug or metabolites, that is caused by the rapid degradation under the influence of tissue Selang peptidase.


Selang is used in adults with anxiety and anxiety-asthenic disorders, appropriate diagnostic criteria for generalized anxiety disorder, neurasthenia, adaptation disorders.


Pregnancy, lactation. Individual intolerance to the drug.

Selang Dosage and Administration

Dropping the drug Selang in the nasal passages of the patient is carried out in a sitting position with his head thrown back a little, and then for a short time, finger pinch each nostril. Suction efficiency may be reduced in the presence of increased excretions of the nasal mucous membrane. Administered at one time is not more than 2-3 drops into each nostril, that is 300 mg (4 drops - 0.2 ml) - 450 g (6 drops - 0.3 mL). To increase the dose of a single dose of the reintroduction of the drug produced in 15 minutes. The optimal single dose - 300-900 mg (4-12 drops) daily - 900-2700 mg (12-36 drops), distributed into 3 doses during the day. The duration of a course of the drug is 10-14 days. If necessary, treatment can be repeated after 1-3 weeks.

Side effect of Selang

If you are sensitive to the perception of smell and taste in contact with the drug from the nasal cavity to the mucosa of the pharynx may appear unpleasant taste. Perhaps the development of allergic reactions if you are hypersensitive.

Overdose of Selang

When using Selang due to the rapid degradation of the drug overdose and intoxication phenomena are observed.
Interaction with other medicinal products.

Selang has no influence on the effects of drugs oppressive and stimulating the central nervous system - gapoperidola, pentobarbital, hexobarbital, analeptics.


Lack of preparation hypnotic-sedative and muscle-relaxant properties, and having a positive influence on cognitive functions allow you to apply Selang in people of different professions, including those requiring special attention and coordination (vehicle drivers, operators, etc.).

Release Form

Nasal drops Selang 0.15%, 3 ml vial 1 NA-PI-1-5, sealed with a plastic cap-pipette. Each vial with instructions for use are packed in a pack of packaging board. On the bottle label glued paper label.
Storage conditions

List B. In the dark place at a temperature no higher than + 10 C, avoid freezing. Keep out of the reach of children.
Shelf life

2 years. Do not use after the date printed on the packaging.
Conditions of supply of pharmacies
On prescription.

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