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Glauprost eye drops - is an antiglaucoma ophthalmic preparation that is analogous to prostaglandin F2α. It is able to reduce the intraocular pressure by activating the outflow of aqueous humor.
Glauprost is an antiglaucoma preparation. It is an analogue of prostaglandin F2α and a selective agonist of FP-receptors. Reduces intraocular pressure by increasing the outflow of watery moisture, mainly along the uveoscleral pathway, and also through the trabecular network. Does not have a significant effect on the production of aqueous humor and does not affect the hemato-ophthalmic barrier. Decrease in intraocular pressure begins 3-4 hours after the administration of the drug, the maximum effect is observed after 8-12 hours, the effect lasts for at least 24 hours.
Well penetrates through the cornea, while hydrolysis occurs to the biologically active form. Time to reach the maximum concentration (TC max) in aqueous humor - 2 hours after topical application.
In the eye tissues, latanoprost acid is not practically metabolized; metabolism occurs mainly in the liver. The half-life (T 1/2) is 17 min. The main metabolites - 1,2-dinor- and 1,2,3,4-tetranormetobodites do not possess or have weak biological activity.
It is excreted by the kidneys.
Causes a gradual change in eye color by increasing the amount of brown pigment in the iris. This effect is mainly seen in patients with mixed iris color, for example, blue-brown, gray-brown, green-brown or yellow-brown, which is explained by an increase in melanin in the stromal melanocytes of the iris. Typically, brown pigmentation spreads concentrically around the pupil to the periphery of the iris of the eyes, while the entire iris or parts of it can acquire a more intense brown color. In the case of an intense change in eye pigmentation, therapy is discontinued.
In patients with uniformly colored eyes of blue, gray, green or brown, eye color changes after 2 years of use of the drug are very rare. The developed color change can be irreversible. Before starting treatment, patients should be informed about the possibility of changing eye color.
The drug contains benzalkonium chloride, which can be absorbed by contact lenses. Before instilling eye drops, contact lenses should be removed; You can insert the lenses only 15 minutes after instillation.
Latanoprost can cause gradual changes in eyelashes and fleece hair, such as lengthening, thickening, increasing pigmentation, increasing the density and changing the direction of growth of the eyelashes. The eyelash changes are reversible and pass after the cessation of treatment.
Patients who apply drops to only one eye may develop heterochromia.
Impact on the ability to drive vehicles and manage mechanisms
Patients who, after the application of eye drops, have a transient fogging of vision, it is not recommended to drive vehicles or work with mechanisms before it is restored.
In the conjunctival bite of the affected eye, drop in 1 drop once a day, in the evening.
When skipping the dose, the next one is administered in the usual mode (i.e., the dose is not doubled).
Important notice- the outer box design may vary before prior notice!
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