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Instruction for use: Relafen

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Active substance Nabumetone

ATX code M01AX01 Nabumetone

Pharmacological groups

Other non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs

Nosological classification (ICD-10)

M00-M25 Arthropathy

M05 Seropositive rheumatoid arthritis

Rheumatoid arthritis seropositive

M15-M19 Osteoarthritis

Composition and form of release

1 tablet, coated, contains nabumetone 500 or 750 mg; in bottles of 100 pcs., in the box 1 bottle.

pharmachologic effect

Pharmacological action - anti-inflammatory, antipyretic, analgesic.


After ingestion, the drug is well absorbed into the digestive tract. Admission simultaneously with food increases the absorption rate. It is subject to rapid biotransformation to the main active metabolite of 6-methoxy-2-naphthylacetic acid (6-MNUC). More than 99% of 6-MNUC binds to plasma proteins. After oral administration of nabumetone in a dose of 1 or 2 g in the equilibrium phase, Cl 6-MNUC is 20-30 ml / min, and the half-life is about 24 hours.


Osteoarthritis, rheumatoid arthritis.


Hypersensitivity, children's age.

pregnancy and lactation

Not recommended.

Side effects

Sleep disorder, dizziness, headache, fatigue, nervousness, agitation, depression, tremor, paresthesia, impaired vision, vasculitis, increased blood pressure, tachycardia, myocardial infarction, angina pectoris, syncope, thrombophlebitis, dyspnea, asthma, eosinophilic pneumonia, abdominal pain, gastritis, diarrhea, constipation, flatulence, nausea, vomiting, dry mouth, gastritis, anorexia, jaundice, stomach and duodenal ulcers, dysphagia, gastroenteritis, increased activity of hepatic transaminases, duodenitis, gallstones, pancreatitis, gingivitis, chl. spasm, hemorrhage from the rectum, anemia, leukopenia, granulocytopenia, thrombocytopenia, albuminuria, hyperuricemia, nephrotic syndrome, interstitial nephritis, dysuria, hematuria, kidney stones, vaginal bleeding, impotence, urticaria, angioedema, photosensitization, toxic epidermal necrolysis, polymorphic erythema , Stevens-Johnson syndrome, chills, fever, sweating, alopecia.


Actively binds to plasma proteins.

Dosing and Administration

Inside, regardless of food intake. 1-2 grams 1-2 times a day.


Symptoms: pain in the abdomen. Treatment: induce vomiting or rinse the stomach. To reduce absorption, activated charcoal (up to 60 g) is used. It is necessary to monitor the vital functions of the body in a hospital.

Precautionary measures

Care should be taken when prescribing the drug to patients with gastrointestinal diseases (even in the anamnesis), weakened and elderly (increased risk of ulceration of the stomach and duodenum, bleeding and perforations); patients with impaired renal and hepatic function; congestive heart failure, arterial hypertension (possible fluid retention in the body).

storage Conditions

Keep out of the reach of children.

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