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DR. DOPING

Instructions

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Instruction for use: Protaphane MC

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Active substance Insulin-isophan [pork monocomponent]

ATX Code A10AC03 Pork insulin

Pharmacological group

insulins

Nosological classification (ICD-10)Z31.1 Artificial insemination

E10 Insulin-dependent diabetes mellitus

Decompensation of carbohydrate metabolism, Diabetes mellitus, Diabetes insulin sugar, Diabetes mellitus type 1, Diabetic ketoacidosis, Insulin-dependent diabetes, Insulin-dependent diabetes mellitus, Coma hyperosmolar non-ketoacidotic, Labile form of diabetes mellitus, Violation of carbohydrate metabolism, Type 1 diabetes mellitus, Type I diabetes mellitus, Insulin-dependent diabetes mellitus, Type 1 diabetes mellitus

E11 Non-insulin-dependent diabetes mellitus

Acetonuric diabetes, Decompensation of carbohydrate metabolism, Diabetes insulin-independent sugar, Diabetes sugar type 2, Type 2 Diabetes, Non-insulin-dependent diabetes, Non-insulin dependent diabetes mellitus, Non-insulin-dependent diabetes mellitus, Insulin resistance, Insulin resistant diabetes mellitus, Coma lactobacillus diabetic, Violation of carbohydrate metabolism, Type 2 diabetes mellitus, Diabetes mellitus type II, Diabetes mellitus in adulthood, Diabetes mellitus in old age, Diabetes insulin-independent, Diabetes mellitus type 2, Sugar insulin-independent diabetes type II

Composition and form of release

1 ml of suspension for injection contains monocomponent pig insulin 100 IU (isophane protamine insulin); In bottles of 10 ml.

pharmachologic effect

Pharmacological action - hypoglycemic.

Interacts with a specific receptor of the plasma membrane and penetrates into the cell, which activates the phosphorylation of cellular proteins, stimulates glycogen synthase, pyruvate dehydrogenase, hexokinase, inhibits fat lipase and lipoprotein lipase. In combination with a specific receptor facilitates the penetration of glucose into cells, enhances its assimilation by tissues and promotes conversion into glycogen. Increases the glycogen reserve in muscles, stimulates the synthesis of peptides.

Clinical Pharmacology

The effect develops 1.5 hours after the SC administration, reaches a maximum after 4-12 hours and lasts for 24 hours.

Indications

Diabetes mellitus type I, type II diabetes mellitus (with resistance to sulfonylurea derivatives, intercurrent diseases, operations and post-operation period, during pregnancy).

Contraindications

Hypoglycaemia, insulinoma.

Side effects

Hypoglycemia, lipodystrophy (with prolonged use), allergic reactions.

Dosing and Administration

Subcutaneously, before use, the flask should be gently shaken (for complete mixing of insulin with a solvent). The dose is determined individually.

Precautionary measures

The dose is necessarily corrected for infectious diseases, surgical interventions, pregnancy, thyroid dysfunction, Addison's disease, hypopituitarism, renal failure, in patients older than 65 years.

Storage conditions

At a temperature of 2-8 ° C. Used vial - at room temperature up to 6 weeks.

Keep out of the reach of children.

Shelf life

2.5 years.

Do not use after the expiry date printed on the package.

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