Instruction for use: Protaphane MC
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Active substance Insulin-isophan [pork monocomponent]
ATX Code A10AC03 Pork insulin
Pharmacological group
insulins
Nosological classification (ICD-10)Z31.1 Artificial insemination
E10 Insulin-dependent diabetes mellitus
Decompensation of carbohydrate metabolism, Diabetes mellitus, Diabetes insulin sugar, Diabetes mellitus type 1, Diabetic ketoacidosis, Insulin-dependent diabetes, Insulin-dependent diabetes mellitus, Coma hyperosmolar non-ketoacidotic, Labile form of diabetes mellitus, Violation of carbohydrate metabolism, Type 1 diabetes mellitus, Type I diabetes mellitus, Insulin-dependent diabetes mellitus, Type 1 diabetes mellitus
E11 Non-insulin-dependent diabetes mellitus
Acetonuric diabetes, Decompensation of carbohydrate metabolism, Diabetes insulin-independent sugar, Diabetes sugar type 2, Type 2 Diabetes, Non-insulin-dependent diabetes, Non-insulin dependent diabetes mellitus, Non-insulin-dependent diabetes mellitus, Insulin resistance, Insulin resistant diabetes mellitus, Coma lactobacillus diabetic, Violation of carbohydrate metabolism, Type 2 diabetes mellitus, Diabetes mellitus type II, Diabetes mellitus in adulthood, Diabetes mellitus in old age, Diabetes insulin-independent, Diabetes mellitus type 2, Sugar insulin-independent diabetes type II
Composition and form of release
1 ml of suspension for injection contains monocomponent pig insulin 100 IU (isophane protamine insulin); In bottles of 10 ml.
pharmachologic effect
Pharmacological action - hypoglycemic.
Interacts with a specific receptor of the plasma membrane and penetrates into the cell, which activates the phosphorylation of cellular proteins, stimulates glycogen synthase, pyruvate dehydrogenase, hexokinase, inhibits fat lipase and lipoprotein lipase. In combination with a specific receptor facilitates the penetration of glucose into cells, enhances its assimilation by tissues and promotes conversion into glycogen. Increases the glycogen reserve in muscles, stimulates the synthesis of peptides.
Clinical Pharmacology
The effect develops 1.5 hours after the SC administration, reaches a maximum after 4-12 hours and lasts for 24 hours.
Indications
Diabetes mellitus type I, type II diabetes mellitus (with resistance to sulfonylurea derivatives, intercurrent diseases, operations and post-operation period, during pregnancy).
Contraindications
Hypoglycaemia, insulinoma.
Side effects
Hypoglycemia, lipodystrophy (with prolonged use), allergic reactions.
Dosing and Administration
Subcutaneously, before use, the flask should be gently shaken (for complete mixing of insulin with a solvent). The dose is determined individually.
Precautionary measures
The dose is necessarily corrected for infectious diseases, surgical interventions, pregnancy, thyroid dysfunction, Addison's disease, hypopituitarism, renal failure, in patients older than 65 years.
Storage conditions
At a temperature of 2-8 ° C. Used vial - at room temperature up to 6 weeks.
Keep out of the reach of children.
Shelf life
2.5 years.
Do not use after the expiry date printed on the package.