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Oftan Timolol eye drops - is an antiglaucomatous drug belonging to a group of nonselective beta-blockers. The mechanism of action of the drug is associated with a decrease in the production of aqueous humor and a slight improvement in the outflow of intraocular fluid. It is well tolerated, it causes a marked decrease in the level of intraocular pressure.
Anti-glaucoma drug, non-selective beta-blocker. Has no internal sympathomimetic and membrane-stabilizing activity. With topical application in the form of eye drops, timolol reduces both normal and increased intraocular pressure by reducing the formation of intraocular fluid. Does not affect the size of the pupil and accommodation.
The effect of the drug manifests itself 20 min after instillation into the conjunctival cavity. The maximum decrease in intraocular pressure occurs after 1-2 hours and persists for 24 hours.
When topical application of timolol maleate quickly penetrates through the cornea. After instillation of eye drops, the maximum concentration of timolol in the aqueous humor of the eye is achieved after 1-2 hours.
80% of timolol, used in the form of eye drops, enters the systemic bloodstream by absorption through the vessels of the conjunctiva, the nasal mucosa and the lacrimal tract. The excretion of timolol metabolites is mainly carried out by the kidneys.
In newborns and small children, the concentration of timolol. as an active substance, significantly exceeds its maximum concentration (Cmax) in adult blood plasma.
Visual impairment, dizziness and fatigue can occasionally be observed with the use of eyedrops Ophthalm Timolol.
It is recommended to control the effectiveness of the drug approximately 3-4 weeks after the start of therapy (not earlier than in 1-2 weeks). With prolonged use of timolol, the effect may be weakened.
When applying, it is necessary to monitor the function of teardropping, the state of the cornea and assess the magnitude of the visual fields at least once every 6 months.
Oftan Timolol contains a preservative of benzalkonium chloride, which can cause eye irritation, absorbed by soft contact lenses, causing a change in their color, and have an adverse effect on eye tissue. Contact lenses should be removed before using the drug and, if necessary, set them again not earlier than 15 minutes after instillation.
When translating patients for treatment with timolol, correction of refractive changes caused by previously used miotics may be required.
Oftan Timolol, like other beta-blockers, can mask possible symptoms of hypoglycemia in patients with diabetes mellitus.
In the case of an upcoming surgical intervention under general anesthesia, it is necessary to cancel the drug 48 hours prior to surgery, because Timolol enhances the action of muscle relaxants and general anesthetics.
Do not bury two different beta-blockers in the same eye.
Impact on the ability to drive vehicles and manage mechanisms
During the treatment period, care must be taken when driving vehicles and during work with complex equipment, requiring increased concentration of attention, rapidity of psychomotor reactions and good vision (within 30 minutes after instillation into the eye), since the drug can reduce blood pressure, cause fatigue and dizziness.
At the beginning of treatment appoint 1-2 drops in the affected eye 2 times / day.
If intraocular pressure with normal use is normalized, you should lower the dose to 1 drop 1 time / day in the morning.
Oftan Timolol treatment is usually carried out for a long time. A break in treatment or a change in the dosage of the drug is carried out only on the instructions of the attending physician.
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