Instruction for use: Pregnyl
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Active substance: Chorionic gonadotropin
ATX code G03GA01 Chorionic gonadotropin
Pharmacological group
Hormones of the hypothalamus, pituitary gland, gonadotropins and their antagonists
Nosological classification (ICD-10)
E23.0 Hypopituitarism
Kalmann's syndrome, Infantilism pituitary, Dwarfism is cerebral-pituitary, Cachexia pituitary, Cachexia diencephalo-pituitary, Anovulatory disorders, Symmonds disease, Secondary hypogonadism in men, Secondary hypogonadotropic hypogonadism, Hypogenitalism, Hypogonadism, Hypogonadism hypogonadotropic, Hypogonadism of the pituitary, Hypogonadism in men, Hypogonadotropic hypogonadism, Hypopituitarism, Pituitary insufficiency, Lack of growth in children with hypopituitarism, Pangypopituitarism, Primary hypogonadism, Primary hypogonadotropic hypogonadism, Shihan Syndrome, Shihina's Syndrome, Symmonds-Glinsky disease, Laron's dwarfism, Sheena's Syndrome, Syndrome of a fertile eunuch
E23.6.0 * Adiposogenital Syndrome
Adiposogenital Syndrome
E25 Adrenogenital disorders
Macroghenytozomy in boys, Adrenogenital syndrome, Decreased function of the sex glands, Congenital dysfunction of the adrenal cortex, Apera-Halle Syndrome, Crook-Apera-Halle Syndrome
E28 Ovarian dysfunction
Dysfunction of the sex glands, Abnormal ovarian function, Non-functioning ovaries, Primary dysfunction of the ovaries, Decreased function of the sex glands, Estrogen insufficiency
E29 Testicular dysfunction
Hypofunction of gonads in men, Androgenic dysfunction, Dysfunction of the sex glands, Dysfunction of gonads in men, Underdevelopment of the genitals in men, Primary hypogonadism in men
E30.0 Delay in puberty
Later sexual development, Sexual maturation later
N46 Male infertility
Azoospermia, Asthenospermia, Infertility, Infertility male, Marriage is infertile, Dispersion, Violations of spermatogenesis, Oligoastenozoospermia III-IV stage, Oligoastenospermia, Oligozoospermia, Oligospermia, Disorders of testicular functions, Spermatogenesis disorders, Inhibition of spermatogenesis, Yang syndrome
N94.6 Dysmenorrhea Unspecified
Pain during menstruation, Functional disorders of the menstrual cycle, Menstrual cramps, Emmeniopathy, Pain during menstruation, Painful menstrual irregularities, algomenorrhea, algomenoreya, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Disalgomenoreya, dysmenorrhea, Dysmenorrhea (essential) (Exfoliative), menstrual disorder, menstruation painful, metrorrhagia, Violation of the menstrual cycle, Menstrual irregularities, Prolaktinzavisimoe menstrual disorders, Prolaktinzavisimoe menstrual dysfunction, Pain spasm of smooth muscles of internal organs, Spasmodic dysmenorrhea, Primary disalgomenoreya
N97 Female infertility
Female infertility in anovulation, Hyperprolactinemic infertility, Hyperprolactinaemia with infertility, Endocrine infertility, Infertility due to hypothalamic-pituitary dysfunction, Infertility infertility, Infertility, Infertility on the background of hyperprolactinaemia, Functional infertility, Marriage is infertile, Infertility of ovarian genesis, Stimulation of the growth of a single follicle
Composition and form of release
1 ampoule with lyophilized powder for the preparation of the injection solution contains human chorionic gonadotropin 500, 1500 or 5000 IU; In a planar cell pack complete with a solvent in ampoules of 1 ml, in a box of 3 sets.
pharmachologic effect
Pharmacological action - gonadotropic.
Stimulates the production of testosterone (in men), estrogens and progesterone after ovulation (in women). Enhances steroidogenesis in the sex glands.
Indications
In men, hypogonadotropic hypogonadism, impaired spermatogenesis, delay in puberty in case of insufficient gonadotropic function of the pituitary gland, cryptorchidism; In women - induction of ovulation and superovulation, incl. Before puncturing the follicles, maintaining the function of the yellow body.
Contraindications
Androgen-dependent tumors (including suspected).
Side effects
Rarely - skin rash; In men, sodium and water retention (when taking high doses). After treatment, there is an increased risk of miscarriage or the development of multiple pregnancies.
Dosing and Administration
Injectively. With hypogonadotropic hypogonadism, dyspermia, delay in rates of puberty in men - 1000-2000 IU 2-3 times a week; When cryptorchidism, children under the age of 6 years - 500-1000 IU 2-3 times a week, over 6 years - 1500 ME 2-3 times a week; Course - 6 weeks, if necessary, can be repeated. To induce ovulation after treatment with humegonom - 5000-10000 IU, once, to maintain the function of the yellow body - 5000-10000 IU 1-3 times (within 9 days after ovulation / puncture of the follicles).
Precautionary measures
They are cautiously prescribed to boys in the prepubertal period, as well as to patients with heart failure, renal dysfunction, arterial hypertension, epilepsy, migraine (including if they have an anamnesis). The drug is recommended to be canceled in case of development of the syndrome of ovarian hyperstimulation.
Storage Conditions
In the dark place at a temperature of 2-15 ° C.
Keep out of the reach of children.
Shelf life
3 years. 5 years solvent
Do not use after the expiry date printed on the package.