Instruction for use: Pensulin SS 100 IU/ml

Active substance Insulin-isophan [pork monocomponent]

ATX Code A10AC03 Pork insulin

Pharmacological group

insulins

Nosological classification (ICD-10)Z31.1 Artificial insemination

E10 Insulin-dependent diabetes mellitus

Decompensation of carbohydrate metabolism, Diabetes mellitus, Diabetes insulin sugar, Diabetes mellitus type 1, Diabetic ketoacidosis, Insulin-dependent diabetes, Insulin-dependent diabetes mellitus, Coma hyperosmolar non-ketoacidotic, Labile form of diabetes mellitus, Violation of carbohydrate metabolism, Type 1 diabetes mellitus, Type I diabetes mellitus, Insulin-dependent diabetes mellitus, Type 1 diabetes mellitus

E11 Non-insulin-dependent diabetes mellitus

Acetonuric diabetes, Decompensation of carbohydrate metabolism, Diabetes insulin-independent sugar, Diabetes sugar type 2, Type 2 Diabetes, Non-insulin-dependent diabetes, Non-insulin dependent diabetes mellitus, Non-insulin-dependent diabetes mellitus, Insulin resistance, Insulin resistant diabetes mellitus, Coma lactobacillus diabetic, Violation of carbohydrate metabolism, Type 2 diabetes mellitus, Diabetes mellitus type II, Diabetes mellitus in adulthood, Diabetes mellitus in old age, Diabetes insulin-independent, Diabetes mellitus type 2, Sugar insulin-independent diabetes type II

Composition and form of release

1 ml of the suspension for injection contains insulin of the pig high-purity monocomponent 100 ED, phenol crystal 0.6 mg and 1.6 mg of metacresol as a preservative; In cartridges of 1.5 ml for syringe pens, in the contour acheive box 5 cartridges, in a carton 1 pack.

Characteristic

Neutral suspension consisting of purified monocomponent pig insulin and protamine sulfate. The suspension is white, when standing, it is stratified, the liquid above the precipitate is transparent or slightly colored, the precipitate is easily resuspended by shaking.

pharmachologic effect

Pharmacological action - hypoglycemic.

It lowers the level of glucose in the blood, increases its absorption by tissues, activates glycogenogenesis, synthesis of protein and lipids, inhibits lipolysis, glycogenolysis and conversion of amino acids into glucose.

Clinical Pharmacology

The preparation of insulin of average duration of action. The effect develops after 1.5 hours after sc administration (subcutaneously), reaches a maximum in the interval 4-12 hours and lasts 24 hours.

Indications

Diabetes mellitus (type 1), diabetes mellitus (type 2) (in the case of resistance to oral hypoglycemic drugs, including (including) partial in combination therapy, against intercurrent diseases, during pregnancy).

Contraindications

Hypersensitivity, hypoglycemia.

Side effects

Hypoglycemia, allergic reactions (skin rash, rarely - angioedema); Hyperemia and itching at the injection site.

Interaction

MAO inhibitors, nonselective beta-blockers, sulfonamides, anabolic steroids, tetracyclines, clofibrate, cyclophosphamide, fenfluramine, preparations containing ethanol increase hypoglycemic effect; Oral contraceptives, glucocorticoids, thyroid hormones, thiazide diuretics, heparin, lithium preparations, tricyclic antidepressants - weaken. Reserpine and salicylates can both weaken and enhance hypoglycemic action.

Dosing and Administration

subcutaneously, the dose is determined individually, before use, the cartridge is gently turned several times up and down. The daily dose exceeding 0.6 units (unit of action) / kg should be given as two injections in different areas of the body.

Overdose

Symptoms: a sharp increase in sweating, palpitation, tremor, hunger, excitement, paresthesia in the mouth, pallor, headache; In severe cases - hypoglycemic coma.

Treatment: ingestion of sugar or foods rich in carbohydrates; In severe cases - the introduction of glucose (40% solution iv (intravenously)) and glucagon (IM / intramuscular), subcutaneously (subcutaneously), iv (intravenously)).

special instructions

Patients receiving more than 100 units (unit of action) / day (day) Pensulin SS, when changing the drug, it is advisable to hospitalize.

The transition from one type of insulin to another should be carried out under the control of blood glucose.

At primary appointment, change of a kind of insulin or occurrence during treatment of stressful situations the ability to control vehicles and mechanisms, to other potentially dangerous kinds of activity requiring attention and speed of reaction is possible.

When changing the nature and diet, significant physical exertion, infectious diseases, surgical interventions, pregnancy, thyroid dysfunction, Addison's disease, hypopituitarism, renal insufficiency, and in patients older than 65 years, the dosage should be adjusted.

Insulin lowers tolerance to alcohol.

Storage conditions

At a temperature of 2-8 ° C (do not freeze).

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.