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Instruction for use: Orgametril

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Active substance Lynestrenol

ATX code G03DC03 Lynestrenol

Pharmacological groups

Estrogens, gestagens; Their homologues and antagonists

Antineoplastic hormonal agents and hormone antagonists

Nosological classification (ICD-10)

C54 Malignant neoplasm of uterus

Uterine cancer, Cancer of the body of the uterus, Sarcoma of the uterus

N60.1 Diffuse cystic mastopathy

Benign cystic change in mammary glands, Cystic fibrosis mastopathy, Fibrous-cystic mastopathy, Pre-cancerous condition of mammary glands, Benign mammary gland disease, Benign breast tumor

N80 Endometriosis

Endometrioid endometriosis

N91 Lack of menstruation, meager and rare menstruation

Amenorrhea, Amenorrhea hypogonadotropic, Amenorrhea is prolactin-dependent, Oligomenorrhoea, Shortening of the secretory phase of the menstrual cycle, Menstrual disorders, Menstruation disorders, Prolactin-dependent amenorrhea without galactorrhea

N94.3 Premenstrual tension syndrome

Pronounced premenstrual syndrome, Menstrual psychosomatic disorder, Menstrual syndrome, Premenstrual tension, Premenstrual status, Premenstrual period, Premenstrual syndrome, Menstruation syndrome

N94.6 Dysmenorrhea Unspecified

Pain during menstruation, Functional disorders of the menstrual cycle, Menstrual cramps, Emmeniopathy, Pain during menstruation, Painful menstrual irregularities, algomenorrhea, algomenoreya, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Disalgomenoreya, dysmenorrhea, Dysmenorrhea (essential) (Exfoliative), menstrual disorder, menstruation painful, metrorrhagia, Violation of the menstrual cycle, Menstrual irregularities, Prolaktinzavisimoe menstrual disorders, Prolaktinzavisimoe menstrual dysfunction, Pain spasm of smooth muscles of internal organs, Spasmodic dysmenorrhea, Primary disalgomenoreya

Composition and form of release

1 tablet contains linestrenol 5 mg; In the blister pack 30 pcs.

pharmachologic effect

Pharmacological action - progestagenic.

It binds to specific cytoplasmic receptors, forming a complex interacting with the chromatin of target cells. Causes the transition of the mucous membrane of the uterus from the proliferation phase to the secretory phase.


Has a pronounced atrophic effect on the myometrium; Suppresses ovulation and menstruation (with continuous reception in a constant mode).

Indications of the drug

Dysfunctional uterine bleeding, amenorrhea, oligomenorrhea, dysmenorrhea, premenstrual syndrome, endometriosis, endometrial carcinoma, benign breast tumor, delay of normal menstruation, hormone replacement therapy with estrogens (as an additional tool).


Severe diseases and liver dysfunction, vaginal bleeding of unclear etiology (including history), severe itching or herpes caused by steroid medication, pregnancy.

Side effects

Nausea, weight gain, bleeding "breakthrough", smearing discharge; Rarely - headache, dizziness, migraine, nervousness, depression, chest pain, jaundice, changes in liver function and lipoprotein profile, lower glucose tolerance, acne, chloasma, hirsutism, skin rash and itching; After the end of treatment - edema and amenorrhea.

Dosing and Administration

Inside. With endometriosis, dysmenorrhea, to suppress menstruation - 1-3 table. Per day for at least 6 months; With carcinoma of the endometrium - 6-10 tablets. in a day; For postponement of normal menstruation - 1-2 tablets. Per day for 1-2 weeks before the expected menstruation. In addition to estrogen therapy - 1 / 2-1 table. Per day for 12-15 days of each month in the second phase of the cycle. In the case of amenorrhea or oligomenorrhea after estrogen preparation of the endometrium and with other indications - 1-2 tablets. Per day, starting from 14-25 days.

Precautionary measures

Patients with circulatory disorders (including history) and severe depressions are recommended periodic additional medical control with a general medical examination.

special instructions

When developing chloasma, avoid exposure to the sun.

storage Conditions

In a dry, the dark place at a temperature of 2-30 C.

Keep out of the reach of children.

Shelf life

5 years.

Do not use after the expiry date printed on the package.

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