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Instruction for use: Naphazoline (Naphazolinum)

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chemical name 4,5-Dihydro-2- (1-naftalinilmetil) -1H-imidazole (in the form of nitrate or hydrochloride)

Pharmacotherapeutic group:

Alpha-adrenoceptor agonists


The nosological classification (ICD-10)

H10.1 Acute atopic conjunctivitis

Allergic conjunctivitis, Allergic eye disease, Allergic conjunctivitis, Allergic conjunctivitis is caused by chemical and physical factors, Allergic rhino-conjunctivitis, Allergic inflammation of the eye, Spring catarrh, Spring keratitis, Spring conjunctivitis, allergic Conjunctivitis, Perennial allergic conjunctivitis, Exacerbation of pollen allergy in the form of Syndrome rhino-conjunctivitis, Acute allergic keratoconjunctivitis, Acute allergic conjunctivitis, Superficial bacterial eye infections, rhino-conjunctivitis Seasonal allergic conjunctivitis, Seasonal conjunctivitis, Sennoz, Chronic allergic keratoconjunctivitis, Chronic allergic conjunctivitis

H10.4 Chronic conjunctivitis

Chronic allergic conjunctivitis, Chronic inflammation of the conjunctiva, Papillary conjunctivitis, phlyctenular keratoconjunctivitis

H68 inflammation and blockage of the ear [Eustachian] pipes

Eustachian,Acute evstahiit, Qatar Eustachian tubes

J00 Acute nasopharyngitis [runny nose]

Viral rhinitis, Inflammation of the nasopharynx, Inflammatory diseases of the nose, purulent rhinitis, Nasal congestion, Nasal congestion with colds and flu, The difficulty of nasal breathing, The difficulty of nasal breathing for colds, Difficulty in nasal breathing, Difficulty in nasal breathing in colds, nasal, hypersecretion, cold, ARI with rhinitis phenomena, coryza, Acute rhinitis of various origins, Acute rhinitis with thick purulent mucous exudate, Acute nasopharyngitis, Swelling of the mucosa of the nasopharynx, Rhinitis, rhinorrhea, Infectious-inflammatory diseases of ENT organs, heavy cold, rhinopharyngitis, nasopharyngitis

J01 Acute sinusitis

Inflammation of the sinuses, Inflammatory diseases of the paranasal sinuses, Purulent inflammation of the paranasal sinuses, Infectious-inflammatory diseases of ENT organs, Infection of the sinuses, Combined sinusitis, Exacerbation of sinusitis, Acute inflammation of the paranasal sinuses, Acute bacterial sinusitis, Acute sinusitis in adults, Subacute sinusitis, acute Sinusitis, sinusitis

J04.0 Acute laryngitis

Lektorsky laryngitis, Acute catarrhal Laryngitis, Laryngitis is an acute abscess

J30 Vasomotor and allergic rhinitis

Allergic rinopatiya, Allergic rhinosinusopathy, Allergic respiratory diseases, Allergic rhinitis, nasal allergy, Seasonal Allergic Rhinitis, Vasomotor rhinitis, Long-allergic rhinitis, Perennial allergic rhinitis, Perennial allergic rhinitis, Year-round or seasonal allergic rhinitis, Year-round allergic rhinitis nature, Rhinitis allergic vasomotor, Exacerbation of pollen allergy in the form of Syndrome rinokonyunktivalnogo, Acute allergic rhinitis, Edema of the nasal mucosa, Edema of the nasal mucosa, Swelling of the mucosa of the nasal cavity, Swelling of the nasal mucosa, Swelling of the nasal mucosa, pollen disease, Permanent allergic rhinitis, rhinoconjunctivitis, rhinosinusitis,rhinosinusopathy, Seasonal allergic rhinitis, Seasonal Allergic Rhinitis, Haymarket rhinitis, Chronic allergic rhinitis, Allergic respiratory diseases

J38.4 Laryngeal edema

Laryngeal edema allergic genesis and background radiation, Acute noninfectious laryngeal edema

J999 * Diagnosis of Respiratory Diseases

bronchography, bronchoscopy, Diagnostic procedures in the nasal passages, Diagnostic Study of the bronchi, laryngoscopy, Preparing for rhinoscopy, Preparing the patient for bronchoscopy and / or bronhografii, Preparing the patient for bronchoscopy or bronhografii, Preparing the patient for diagnostic procedures in the nasal passages, Preparing the patient for diagnostic procedures in the area of the nasal passages, rhinoscopy, Visualization of the chest cavity, Chest X-ray, Mediastinoscopy

R04.0 Epistaxis

Bleeding nose, nosebleeds

CodeCAS 835-31-4


White or white with a yellowish tinge crystalline powder odorless. It is soluble in water, soluble in alcohol, slightly soluble in acetone, is very small - in chloroform, insoluble in hexane.

Pharmacological Properties of NaphazolinePharmachologic effect
vasoconstrictor, decongestant, alpha-agonists.

Excited alpha 1 and alpha2 adrenergic receptors causes vasoconstriction (primarily acts on the blood vessels with the greatest density of alpha-adrenoceptor - mucosal vessels and kidney), narrows the pupil, has anti-inflammatory (decongestants) properties. Vasoconstrictor effect in topical application to the nasal mucosa and eye occurs within a few minutes and lasts for several hours. In rhinitis nasal breathing easier by reducing blood flow to the venous sinuses. Systemic effect is an increase in blood pressure.

When applied topically, it is absorbed into the systemic circulation. Good and quickly absorbed tear glands. nafazolina of distributed data is not in humans. It does not pass through the BBB.

With long-term effect of the appointment of gradually decreasing (tolerance development), and after 5-7 days of a break for a few days.

Indications for Naphazoline
Acute rhinitis, hay fever, sinusitis, sinusitis, laryngitis, evstahiit, laryngeal edema, allergic genesis and background exposure, redness of the mucous membrane after surgery on the upper airway, nosebleeds, chronic conjunctivitis; rrhinoscopy (in combination with local anesthetics).

Contraindications for Naphazoline

Hypersensitivity, angle-closure glaucoma, hypertension, tachycardia, expressed atherosclerosis, severe eye disease, diabetes, hyperthyroidism, chronic rhinitis, simultaneous reception of MAO inhibitors and ten since the end of their use, children's age (up to 1 year).

Pregnancy and breast-feeding

Category effects on the fetus by FDA - C.

Updating of information


Not conducted safety studies of application nafazolina during pregnancy in animals. There are no data on the ability nafazolina cause abnormalities of fetal development when used in pregnant women. There is no information on the effect of nafazolina reproductive capacity of women.

Application nafazolina in pregnant women is possible only in case of emergency.


It is not known whether naphazoline is excreted in breast milk in humans. Taking into account the fact that many drugs are excreted in human milk, caution should be exercised by appointing naphazoline during lactation.

Side effects

Local reactions: irritation, reactive hyperemia; long-term use - the swelling of the mucous membrane.

Systemic reactions: nausea, headache, increased blood pressure, tachycardia.

Updating of information

For more information about side effects of the substance naphazoline

Local reactions: mydriasis, discomfort, blurred vision, punctate keratitis, tearing, increased intraocular pressure.

Systemic reactions: dizziness, sweating, irritability, drowsiness, weakness, disorders of the heart, hyperglycemia.


It slows down the absorption of local anesthetics. Tricyclic antidepressants, maprotiline - enhance the effect. Incompatible with MAO inhibitors.


Symptoms: lowering of body temperature, bradycardia, increase in blood pressure.

Treatment: symptomatic.

Routes of administration

In otorhinolaryngology: intranasally.

If nosebleeds: introduction into the cavity of the nose tampons.

In ophthalmology: the cavity of the conjunctiva.

When rhinoscopy to prolong the surface anesthesia.


Updating of information

The use of sympathomimetic agents, in particular drugs nafazolina, in patients receiving drugs containing MAO inhibitors, may lead to severe hypertensive crisis. Using nafazolina drugs in children, particularly infants, can cause depression of the central nervous system activity, leading to coma lowered body temperature.

Only for topical application. Use cautiously nafazolina drugs in hypertension and other diseases, cardiovascular diseases, hyperglycemia (diabetes), hyperthyroidism, infectious process, with injuries and the presence of wound surfaces.

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