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Instructions

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Instruction for use: Metaprot

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Trade name of the drug – Metaprot

International name of the drug: ethylthiobenzimidazole

Dosage Form: capsules
Composition:
(Per capsule) Active ingredient: ethylthiobenzimidazole hydrobromide monohydrate is 50 mg or 125 mg, or 250 mg (calculated as anhydrous substance).
Excipients: giproloza, colloidal silicon dioxide, lactose, magnesium stearate. hard gelatine capsules contain: for dosing of 50 mg - water, gelatin, coloring agent sunset yellow (E 110), quinoline yellow dye (E 104), methyl parahydroxybenzoate, propyl parahydroxybenzoate, titanium dioxide (E 171); for dosing of 125 mg - water, gelatin, coloring agent sunset yellow (E 110), methyl parahydroxybenzoate, propyl parahydroxybenzoate, titanium dioxide (E 171); for dosing of 250 mg - water, gelatin, dye Ponceau Ponceau 4R (E 124), Sunset Yellow dye solar (E 110), methyl parahydroxybenzoate, propyl parahydroxybenzoate, titanium dioxide (E 171).
Description:

The dosage of 50 mg - Capsules number 3, the body is white, yellow cap. The dosage of 125 mg - 2 ¹ capsules, body in white, orange-colored cover. The dosage of 250 mg - Capsules ¹ 0, white body, cover a dark orange color.The contents of capsules - a mixture of powder and granules of white or white with a color shade.
Pharmacotherapeutic group:

Adaptogenic agent

ATX Code À13À
Pharmacological Properties
Pharmacodynamics.

The drug Metaprot has nootropic, regenerative, anti-hypoxic, antioxidant and immunomodulatory activity baseband. The mechanism of action is to activate the synthesis of RNA, and then proteins, including enzymatic and related to the immune system. The activation of the synthesis of enzymes of gluconeogenesis that provide recycling of lactate (a factor limiting performance) and resynthesis carbohydrates - a source of energy during intense loads, which leads to increased physical performance. Increased synthesis of mitochondrial enzymes and structural proteins of the mitochondria provides an increase in energy production and maintaining a high degree of coupling of oxidation and phosphorylation. Keeping a high level of ATP synthesis with the oxygen deficiency contributes to the pronounced anti-hypoxic and anti-ischemic activity. It enhances the synthesis of antioxidant enzymes, and has a pronounced antioxidant activity. It increases the body's resistance to extreme factors - physical activity, stress, hypoxia, hyperthermia. Increases performance during physical exertion. It has a pronounced anti-asthenic action and accelerates recovery processes after extreme impacts. 

Pharmacokinetics.

After oral administration of Metaprot is well absorbed from the gastrointestinal tract is actively metabolized in the liver. After a single dose is found in the blood after 30 minutes, the maximum effect is achieved after 1-2 hours, 4-6 hours duration. Against the background of course taking effect usually increases during the first 3-5 days, then steadily maintained at current levels. Prolonged course continuous reception, especially at high doses, there may be a tendency to accumulation of the drug with an increase in the blood concentration to 10-12 day application.

Indications
Improved performance and recovery, including in extreme conditions (heavy exercise, hypoxia, hyperthermia). Adaptation to the effects of various extreme factors. Asthenic disorders of different nature (in neurasthenia, somatic diseases, after serious infections and intoxications, pre- and postoperative period in surgical interventions). In the combined therapy: craniocerebral trauma, meningitis, encephalitis, cerebral circulatory disorders, cognitive disorders.

Contraindications

Hypersensitivity, hypoglycemia, marked disturbances of liver function, pregnancy, lactation, epilepsy, hypertension, glaucoma, ischemic heart disease, arrhythmias, lactase deficiency, lactose intolerance, glucose-galactose, malabsorption, child.

Metaprot Dosage and Administration
Inside, after a meal. Adults 0.25 g, 2 times a day. If necessary, the daily dose was increased to 0.75 g (0.5 g and 0.25 g in the morning - after lunch), and persons with a body weight above 80 kg - 1 g (0.5 g, 2 times a day). The course of treatment - 5 days with 2-day intervals between them in order to avoid accumulation of the drug. Number of treatments depends on the effect and an average of 2-3 (rarely 1 or 4-6) courses. To improve performance in extreme conditions take medication for 40-60 minutes before the upcoming activity at a dose of 0.5-0.75 g If you continue to work through readmission produce 68 hours at a dose of 0.25, the maximum daily dose - 1.5 g, and the next day 1 in order to maintain a high level of performance for a long time (several weeks), and for the activation of adaptation processes of the drug administered according to the scheme 5-day admission to the courses 2-day intervals at a dose of 0.25 g 2 times per day.

Side effect of Metaprot
Unpleasant sensations in the stomach and liver, rarely - nausea, vomiting, allergic reactions (facial flushing, rhinitis), headache. In these cases it is necessary to reduce the dose or stop taking.

Overdose

Symptoms: irritability, disturbance of nighttime sleep. Treatment: gastric lavage, activated charcoal, if necessary - symptomatic therapy should reduce the dose or stop taking the drug.
Interaction with other medicinal products.

Inhibitors of microsomal liver enzymes CYP1A2, CYP2C9, CYP2D6, CYP3A4 (for example, cimetidine) can increase the concentration of drug in the blood. It enhances the beneficial effects of metabolic drugs (including inosine), nootropic drugs (including piracetam) antihypoxants (including trimethyl zidin), potassium and magnesium asparaginate, glutamic acid, vitamins (including alpha-tocopherol) and antianginal drugs (nitrates, beta-blockers).

SPECIAL INSTRUCTIONS
Do not take in the evening (possible violation sleep). During treatment, it is recommended a diet rich in carbohydrates.

Release Form
Capsules 50 mg, 125 mg, 250 mg. 10 capsules in a single dosage or strip cellular upakovke.2 5 contour cell packages with instructions for use in a stack of cardboard. According to one dosage 100 capsules in a polymeric jar. Each polymer bank with instructions for use in a stack of cardboard.
Storage conditions
List B. In a dry, dark place at a temperature no higher than 25 ° C. Keep out of the reach of children.
Shelf life
3 years. Do not use beyond the expiration date printed on the package.
Conditions of supply of pharmacies
On prescription.

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