Instruction for use: Menotropins (Menotropina)

Pharmacological group

Hormones of the hypothalamus, pituitary gland, gonadotropins and their antagonists

Nosological classification (ICD-10)

E25 Adrenogenital disorders

Macroghenytozomy in boys, Adrenogenital syndrome, Decreased function of the sex glands, Congenital dysfunction of the adrenal cortex, Apera-Halle Syndrome, Crook-Apera-Halle Syndrome

E28 Ovarian dysfunction

Dysfunction of the sex glands, Abnormal ovarian function, Non-functioning ovaries, Primary dysfunction of the ovaries, Decreased function of the sex glands, Estrogen insufficiency

E29 Testicular dysfunction

Hypofunction of gonads in men, Androgenic dysfunction, Dysfunction of the sex glands, Dysfunction of gonads in men, Underdevelopment of the genitals in men, Primary hypogonadism in men

N46 Male infertility

Azoospermia, Asthenospermia, Infertility, Infertility male, Marriage is infertile, Dispersion, Violations of spermatogenesis, Oligoastenozoospermia III-IV stage, Oligoastenospermia, Oligozoospermia, Oligospermia, Disorders of testicular functions, Spermatogenesis disorders, Inhibition of spermatogenesis, Yang syndrome

N97 Female infertility

Female infertility in anovulation, Hyperprolactinemic infertility, Hyperprolactinaemia with infertility, Endocrine infertility, Infertility due to hypothalamic-pituitary dysfunction, Infertility infertility, Infertility, Infertility on the background of hyperprolactinaemia, Functional infertility, Marriage is infertile, Infertility of ovarian genesis, Stimulation of the growth of a single follicle

Code CAS60252-39-3

Pharmacology

Pharmacological action - gonadotropic.

Increases the level of sex hormones in the blood plasma. In women, it stimulates the maturation of follicles in the ovaries (before the pre-ovulatory stage), increases the level of estrogens, activates the proliferation of the endometrium; In men, it affects the Sertoli cells of the seminiferous tubules and induces spermatogenesis. Increases the production of steroid hormones by the sex glands. The effectiveness is mainly due to the action of FSH. Cmax FSH is achieved 6-24 hours after the / m administration. T1 / 2 - 4-12 hours.

Indications

In women: infertility due to hypothalamic-pituitary disorders (hypogonadotropic hypogonadism), inferior maturation of the follicle (deficiency of the yellow body), controlled superovulation with in vitro fertilization (in combination with human HG).

In men: oppression of spermatogenesis (azoospermia, oligoastenospermia due to primary or secondary hypogonadotropic hypogonadism).

Contraindications

Hypersensitivity, tumors of the hypothalamic-pituitary region, hyperprolactinaemia, kidney and pancreas diseases; For women - pregnancy, hypertrophy and cyst of the ovaries, polycystic ovaries, uterine bleeding of unclear etiology, estrogen-dependent tumors of the uterus, ovaries, mammary glands, uterine myoma, primary ovarian failure, anomalies in the development of genital organs; For men - prostate cancer or other androgen-dependent tumors.

Side effects

Syndrome of ovarian hyperstimulation (with possible development of large ovarian cysts, ascites, hydrothorax, thromboembolism, oliguria, hypotension), multiple pregnancy, dyspeptic phenomena (nausea, vomiting), fever, arthralgia, mastalgia, gynecomastia (in men), skin rash, urticaria ( The formation of antibodies with prolonged use).

Interaction

The effect is weakened by gonadotropin-releasing hormone agonists. Clomiphene increases the reaction of the follicle.

Routes of administration

In / m (intramuscularly), subcutaneously

Precautions

Before the beginning of treatment it is necessary to exclude extragenital endocrinopathies. During the period of therapy, daily hormonal control and ultrasound of developing follicles are mandatory (the reaction of the ovaries can be evaluated according to the cervical index). In case of the threat of ovarian hyperstimulation syndrome, menotropins are canceled.

Do not mix with other medicines in the same syringe.

In men with high blood levels of FSH, menotropins are ineffective.

The prepared drug solution is used immediately.