Instruction for use: Insulin-aminoquinuride [pork monocomponent] (Insulinum aminoquinuridum [porcinum monocomponentum])

Pharmacological group

Insulins

Nosological classification (ICD-10)

E10 Insulin-dependent diabetes mellitus

Decompensation of carbohydrate metabolism, Diabetes mellitus, Diabetes insulin sugar, Diabetes mellitus type 1, Diabetic ketoacidosis, Insulin-dependent diabetes, Insulin-dependent diabetes mellitus, Coma hyperosmolar non-ketoacidotic, Labile form of diabetes mellitus, Violation of carbohydrate metabolism, Type 1 diabetes mellitus, Type I diabetes mellitus, Insulin-dependent diabetes mellitus, Type 1 diabetes mellitus

Characteristics

Monocomponent (chromatographically pure) porcine insulin-aminoquinuride of average duration of action (10-12 h).

Pharmacology

Pharmacological action - hypoglycemic.

Reduces the level of glucose in the blood, glucosuria, increases the absorption of glucose by tissues (facilitates its penetration into cells). Enhances protein synthesis, lipogenesis and glycogenogenesis, reduces the rate of glucose production by the liver. The action begins 45-60 minutes after the SC administration, reaches a maximum after 2-6 hours, continues - 10-14 hours.

Indications

Insulin-dependent diabetes mellitus (type 1), non-insulin-dependent diabetes mellitus (type 2) with resistance to oral hypoglycemic drugs); Intercurrent diseases or operations in patients with diabetes mellitus.

Contraindications

Hypersensitivity, hypoglycemia, insuloma, paragroup allergy, pronounced decompensation of metabolism.

Side effects

Hypoglycemia, hypoglycemic precoma and coma, lipohypertrophy, lipodystrophy, transient edema, hypermetropia, increase in the titer of anti-insulin antibodies, allergic reactions.

Interaction

The hypoglycemic effect is enhanced by MAO inhibitors, nonselective beta-blockers, sulfonamides and alcohol, weakening - oral contraceptives, glucocorticoids, thyroid hormones, thiazide diuretics.

Overdose

Symptoms: hypoglycemia.

Treatment: the appointment of glucose inside (if the patient is conscious), parenteral administration of glucagon or glucose (IV).

Routes of administration

F / k, in / m.

Precautions

You can not enter IV (intravenously).

special instructions

It should be borne in mind that during pregnancy, the need for insulin increases.