Instruction for use: Heparin sodium + [Allantoin + Dexpanthenol]

Trade name of the drug – Hepalpan; Hepatrombin

The Latin name of the substance Heparin sodium + [Allantoin + Dexpanthenol]

Heparinum natrium + [Allantoinum + Dexpanthenolum] (genus. Heparini natrii + [Allantoini + Dexpanthenoli])

Pharmacological groups:

Regenerants and reparants in combinations

Anticoagulants in combination

Model clinical-pharmacological article 1

Pharmacotherapy. Combined preparation for topical application. Heparin prevents the formation of blood clots, has anti-edematous and anti-inflammatory effect, improves local blood flow. Allantoin has an anti-inflammatory effect, stimulates metabolic processes in tissues and promotes cell proliferation. Dexapanthenol improves the absorption of heparin, stimulates granulation and tissue epithelialization. Essential oils have antiseptic and analgesic effect.

Pharmacokinetics. After local application to the skin, heparin relatively quickly penetrates through the epidermis and accumulates in the upper layers of the skin. From the tissues is slowly withdrawn from T1 / 2 for about 1 hour. The therapeutic concentration is from 10 U / ml in the epidermis and 0.6 U / ml in the skin.

Indication. Thrombosis, thrombophlebitis, varicose veins; Trophic ulcers of the lower leg; Sports injuries, tendovaginitis; Inflammatory infiltrates; Lymphangitis; mastitis; furuncle; carbuncle.

Contraindications. Hypersensitivity, violation of the integrity of the skin.

Dosing. Outwardly. On the affected areas 1-3 times a day, a column of ointment with a length of 5 cm is applied. When treating diseases, the veins are used in the form of dressings with ointment. When varicose ulcers ointment is applied in the form of a ring about 4 cm wide. When diseases of the veins of the lower extremities, the ointment is applied with light rubbing movements from the bottom to the top, a single dose is recommended to be rubbed not completely, but in separate portions.

Side effect. Allergic reactions (skin rash, skin hyperemia, hives, angioedema).

Special instructions. For diseases of the veins of the lower extremities, the ointment is applied with light rubbing movements in the direction from the bottom to the top, a single dose is recommended to be rubbed not completely, but in separate portions.