Instruction for use: Gliatilin

Trade name of the drug – GLIATILIN

International nonproprietary name: choline alfoscerate

The name of the active substance in Latin: Cholini alfosceras

Dosage Form: Gliatilinpills, Gliatilin injections Chemical name: Choline hydroxide, (R) -2,3-dihydro-ksipropil-phosphate (inner salt)

Composition:
Release form, composition and packing

The capsules are oval, yellow, opaque, soft gel, containing a viscous, colorless solution.

1 caps.
400 mg of choline alfoscerate
Excipients: glycerol, purified water.

Composition Capsule shell: Gelatin, ezitol, sorbitans, sodium ethyl parahydroxybenzoate, propyl parahydroxybenzoate sodium, titanium dioxide (E171), iron (III) metahydroxide (E172).

14 - blisters (1) - packs cardboard.

The solution for the on / in and / m the introduction of transparent, colorless, odorless.
choline alfoscerate injection 1 mL of 1 amp.
250 mg 1 g

Excipients: water d / and.

4 ml - colorless glass vials (3) - packings Valium planimetric (1) - packs cardboard.

Pharmacotherapeutic group:Neuroprotective drugs. Choline-mimetic of central action
Pharmacological Properties

pharmachologic effect of Gliatilin

Neuroprotective drugs. Choline-mimetic central action with a primary effect on the central nervous system. Choline release of active substance takes place in the brain; Choline is involved in the biosynthesis of acetylcholine (one of the main mediators of nerve excitation). Alfostserat biotransformed to glycerophosphate, which is a precursor of phospholipids.
Acetylcholine improves the transmission of nerve impulses, and glycerophosphate involved in the synthesis of phosphatidylcholine (phospholipid membrane) to improve the elasticity of the membrane and the function of receptors.

Gliatilin increases cerebral blood flow, enhances metabolic processes and activates the brain structure of the reticular formation and restores consciousness in traumatic brain damage.
It has a preventive and a corrective effect on the factors psychoorganic involutional syndrome, such as changing the composition of phospholipid membranes of neurons and decreased cholinergic activity.
Thus, pharmacodynamic studies showed that the effect on synaptic Gliatilin, including cholinergic neurotransmission (neurotransmission); plasticity of the neuronal membrane; receptor function.

Pharmacokinetics of Gliatilin
Absorption and distribution
After oral administration, absorption is 88%.
Easily penetrates through the BBB, predominantly accumulates in the brain (the concentration reaches 45% of the level in blood plasma), lung and liver.
Metabolism and excretion
85% of output light in the form of carbon dioxide, the remainder (15%) - via the intestine and kidneys.

Indications for Gliatilin- Acute period of craniocerebral trauma mainly stem lesions (including the violation of consciousness, coma);
- Disorders of cerebral circulation on ischemic type (acute and recovery period) and hemorrhagic type (recovery period);
- Degenerative involution and psycho-organic syndromes and consequences of cerebrovascular disease, such as primary and secondary disturbances mnemonic functions, characterized by memory impairment, confusion, disorientation, decreased motivation, initiative and the ability to concentrate;
- Changes in emotional and behavioral sphere: emotional lability, irritability, decreased interest; senile psevdomelanholiya;
- Multi-infarct dementia.

Contraindicationsof Gliatilin
- Hypersensitivity to the drug.

Use of the drug Gliatilin during pregnancy and lactation.

Use of the drug during pregnancy and lactation (breastfeeding) is contraindicated.
Dosing and Administration of Gliatilin

The capsules are taken orally before meals; the solution is introduced into / m or / in the drip.
In acute conditions / m at a dose of 1 g (1 ampoule) per day or / - 1 g to 3 g per day.
With on / in a content of 1 vial (4 ml) was diluted in 50 ml saline; infusion rate - 60-80 drops / min. Duration of treatment is usually 10 days, but if necessary, treatment can be continued until the positive dynamics and the possibility to switch to the capsules.
In chronic cerebrovascular insufficiency, changes in emotional and behavioral sphere and multi-infarct dementia drug appointed interior 400 mg (1 capsule). 3
The duration of treatment is 3-6 months.

Side effects of Gliatilin

Perhaps: nausea (as a consequence of the activation of the dopaminergic), and allergic reactions.
Typically, the drug is well tolerated even in long-term use.

Overdose of GliatilinSymptoms: Nausea. When this symptom is recommended to reduce the dose of the drug.
Interaction with other drugsDrug Interactions of drug Gliatilin is not established.
Special instructions for GliatilinEffects on ability to drive vehicles and management mechanisms

Gliatilin does not affect the patient's ability to engage in potentially hazardous activities.
Effects on ability to drive vehicles
Not noted.

Storage conditions of Gliatilin
In a dry place inaccessible to children.
Shelf life of Gliatilin
4 years. Do not use beyond the expiration date.
Conditions of supply of pharmacies
On prescription