Instruction for use: Distigmine bromide (Distigmini bromidum)

Chemical name

3,3 '- [1,6-Hexanediylbis [(methylimino) carbonyl] oxy] bis [1-methylpyridinium] dibromide

Pharmacological group

M-, n-holinomimetiki, incl. Anticholinesterase agents

Nosological classification (ICD-10)

G70 Myasthenia gravis and other disorders of the neuromuscular synapse

Myasthenic syndrome, Myasthenic syndromes, Myasthenia gravis, Myasthenic syndrome, Severe myasthenia gravis (Myasthenia gravis)

G83 Other paralytic syndromes

Paralysis, Peripheral paralysis, Brown-Sekara Syndrome, Brown-Sekar Syndrome, Hemiparaplegic syndrome, Syndrome of half damage to the spinal cord, Peripheral paralysis of striated muscles

K59.0.0 * Constipation hypo- and atonic

Atonic constipation, Acute functional constipation, Constipation of various etiologies due to hypotension of the gastrointestinal tract and flaccid peristalsis of the large intestine, Constipation of various etiologies, caused by hypotension and sluggish peristalsis of the colon with a change in the nature of nutrition and place of stay, Reduction of the evacuation function of the large intestinem Chronic atonic constipation, Chronic hypotonic constipation, Acute constipation, Preparation of the lower GI tract for endoscopy

N31.2 Neurogenic weakness of the bladder, not elsewhere classified

Urinary incontinence in a stressful situation, Atony of the bladder, Atony of the bladder (sphincter) (neurogenic), Violation of the function of the sphincter of the bladder, Neurogenic impairment of bladder function, Neurogenic disorders of the bladder, Neurogenic bladder, Functional deficiency of the sphincter of the bladder, Imperative incontinence

Code CAS15876-67-2

Characteristics

Powder of white color. Soluble in water.

Pharmacology

Pharmacological action - m-n-cholinomimetic indirect.

Inhibits (reversibly) acetylcholinesterase and leads to the accumulation of acetylcholine in the synaptic cleft. The clinical effect develops within 1-1.5 hours after ingestion. Stimulates secretion of exocrine glands, increases tone and peristalsis of the intestine and bladder. Increase in the tone of the gastrointestinal tract reaches a maximum after 8-10 hours and persists for 20 hours. It acts on the cardiovascular system: it has a moderate vasodilating and negative chronotropic effect. Increases the tone of skeletal muscles, especially with myasthenia gravis (a noticeable effect appears on the 1-2-day intake).

Indications

Paralytic ileus, postoperative atony of the intestine (prevention and treatment), chronic constipation, atony of the bladder and ureters, neurogenic disorders of urination associated with functional deficiency of the sphincter of the bladder, myasthenia gravis.

Contraindications

Hypersensitivity (including bromine), pronounced vagotonia (bradycardia, arterial hypotension, hyperacid conditions, increased salivation), bronchial asthma, reflux disease, stomach ulcer, inflammatory bowel disease; Intestinal, renal and hepatic colic, chronic heart failure, myocardial infarction, violation of peripheral circulation, thyrotoxicosis, clonic and tonic convulsions, parkinsonism, pregnancy, breast-feeding.

Side effects

Dyspeptic phenomena, hypersalivation, intestinal colic, broncho-obstructive disorders, sinus bradycardia, miosis, sweating, tremor, muscle spasms, swallowing difficulties, menstrual bleeding (with functional amenorrhea).

Interaction

Anticholinergic and cholinolytic activity (psychotropic, antihistaminic, aminoglycosides) drugs weaken the effect.

Overdose

Symptoms: hypersalivation, nausea, vomiting, diarrhea, pain in the stomach of a spastic nature, muscle weakness, fasciculation, sweating, bronchospasm, severe bradycardia.

Treatment: atropine is used as a specific antidote.

Routes of administration

Inside, in / m.

Precautions

Do not use during work drivers of vehicles and people whose profession is associated with increased concentration of attention. It is necessary to adhere strictly to the regimen (no more than 1 time per day), and with long-term treatment, one-day breaks (cumulation is possible).