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Instruction for use: Dexketoprofen (Dexketoprophenum)

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Pharmacological group

NSAIDs - Propionic acid derivatives

Nosological classification (ICD-10)

K08.8.0 * Painful toothache

Dentinal pain, Dentinal pains, Pain pulpitis, Anesthesia in dentistry, Pain syndromes in dental practice, Pain after removal of tartar, Pain when extracting a tooth, Toothache, Pain after dental interventions

M06.9 Other specified rheumatoid arthritis

Rheumatoid arthritis, Pain syndrome in rheumatic diseases, Pain in rheumatoid arthritis, Inflammation in rheumatoid arthritis, Degenerative forms of rheumatoid arthritis, Children's rheumatoid arthritis, Exacerbation of rheumatoid arthritis, Acute articular rheumatism, Rheumatic arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatoid arthritis, Rheumatoid arthritis of active course, Rheumatoid periarthritis, Rheumatoid polyarthritis, Acute Rheumatic Arthritis, Acute rheumatism

M19.9 Arthrosis, unspecified

Change in brush with osteoarthritis, Osteoarthritis, Osteoarthrosis, Arthrosis of large joints, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Deforming arthrosis, Deforming osteoarthritis, Deforming osteoarthritis of joints, Osteoarthritis in the acute stage, Osteoarthritis of large joints, Acute pain syndrome with osteoarthritis, Post-traumatic osteoarthritis, Rheumatic osteoarthritis, Spondylarthrosis, Chronic osteoarthritis

M42.9 Osteochondrosis of spine, unspecified

Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Diseases of the spinal column, Osteochondrosis of the spine with radicular syndrome

M45 Ankylosing spondylitis

Ankylosing spondylarthrosis, Marie-Strumpel disease, Ankylosing spondylitis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Bechterew's disease, Ankylosing spondylitis, Diseases of the spinal column, Rheumatic spondylitis, Bechterew-Marie-Strumpel disease

N94.6 Dysmenorrhea Unspecified

Pain during menstruation, Functional disorders of the menstrual cycle, Menstrual cramps, Emmeniopathy, Pain during menstruation, Painful menstrual irregularities, algomenorrhea, algomenoreya, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Disalgomenoreya, dysmenorrhea, Dysmenorrhea (essential) (Exfoliative), menstrual disorder, menstruation painful, metrorrhagia, Violation of the menstrual cycle, Menstrual irregularities, Prolaktinzavisimoe menstrual disorders, Prolaktinzavisimoe menstrual dysfunction, Pain spasm of smooth muscles of internal organs, Spasmodic dysmenorrhea, Primary disalgomenoreya

R52.9 Unspecified Pain

Pain after cholecystectomy, Pain shooting, Non-malignant pain, Obstetric and gynecological pain, Pain syndrome, Pain in the postoperative period, Pain in the postoperative period after orthopedic surgery, Pain of inflammatory genesis, Pain than cancer genesis, Pain syndrome after diagnostic procedures, Pain after surgery Diagnostic, Pain after surgery, Pain after orthopedic surgery, Pain after injuries, Pain after the removal of hemorrhoids, Pain at the non-rheumatic inflammation of nature, Pain in inflammatory lesions of the peripheral nervous system, Pain in diabetic neuropathy, Pain in acute inflammatory diseases of the musculoskeletal system, Pain when the tendon pathology, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs, Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Pain in trauma syndrome, Pain with injuries and after surgical interventions, Pain in chronic inflammatory diseases of the musculoskeletal system, Pain with duodenal ulcer, Pain syndrome in gastric ulcer, Pain syndrome in gastric ulcer and duodenal ulcer, pain, Pain during menstruation, pain syndromes, painful condition, Painful foot fatigue, Sore gums when wearing dentures, Soreness of the cranial nerves exit points, Painful menstrual irregularities, Painful dressings, Painful muscle spasm, Painful teeth growth, Melosalgia, Pain in the area of the surgical wound, Pain in the postoperative period, Pain in the body, Pain after diagnostic procedures, Pain after orthopedic surgery, Pain after surgery, The pains of the flu, Pain in diabetic polyneuropathy, Pain for burns, Pain during sexual intercourse, Pain during diagnostic procedures, Pain during therapeutic procedures, for colds Pain, Pain in sinusitis, Pain in trauma, Pain traumatic, The pain in the postoperative period, Pain after diagnostic procedures, The pain after sclerotherapy, Pain after surgery, postoperative Pain, Pain postoperative and posttraumatic, posttraumatic pain, Pain when swallowing, Pain in infectious and inflammatory diseases of the upper respiratory tract, The pain of burns, The pain in traumatic muscle injury, Pain in trauma, The pain of tooth extraction, The pain of traumatic origin, Pain caused by spasm of smooth muscles, Expressed pain syndrome, Expressed pain syndrome, traumatic origin, Postoperative pain, Post-traumatic pain, Post-traumatic pain syndrome, Torpid pain, Traumatic pain, Traumatic pain, Mild pain, Moderately severe pain, Moderate pain, Polyarthralgia with polymyositis

Code CAS 22161-81-5

Characteristics of Dexketoprofen

NSAIDs (non-steroidal anti-inflammatory drugs). Dexketoprofen trometamol is a water soluble salt of the S-enantiomer of ketoprofen.

Pharmacology

Pharmacological action - anti-inflammatory, antipyretic, analgesic.

Reduces the synthesis of PG (prostaglandins) due to the suppression of the cyclooxygenase system (COX-1 and COX-2).

After oral administration, Cmax is reached after 30 (15-60) minutes. The distribution time is 0.35 h, T1 / 2 is 1.65 h. The average volume of distribution is less than 0.25 l / kg. Binding to plasma proteins - 99%. It is excreted mainly by the kidneys after glukuronirovaniya.

Analgesic effect occurs 30 minutes after admission and lasts 4-6 hours.

Application of dexketoprofen

Pain syndrome, incl. with acute and chronic inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, spondyloarthritis, arthrosis, osteochondrosis); menstrual and toothache.

Contraindications

Hypersensitivity (including other NSAIDs), peptic ulcer and duodenal ulcer, gastrointestinal bleeding or other active bleeding, a tendency to bleeding, anticoagulant therapy, gastrointestinal diseases (Crohn's disease, ulcerative colitis), bronchial asthma (including history), severe heart failure, renal and / or hepatic insufficiency, pregnancy, the period of breastfeeding.

pregnancy and lactation

Contraindicated in pregnancy and breast-feeding due to lack of sufficient data to confirm the safety of use.

Side effects of dexketoprofen

On the part of the digestive tract (gastrointestinal tract): heartburn, abdominal pain, occasionally - erosive-ulcerative gastrointestinal lesion.

From the nervous system and sensory organs: headache, dizziness, nervousness, sleep disturbance, paresthesia.

From the cardiovascular system and blood (hematopoiesis, hemostasis): palpitation, increased blood pressure; rarely - a violation of the picture of blood.

From the genitourinary system: rarely - a violation of kidney function.

Allergic reactions: skin rash, bronchospasm.

Other: chills, swelling of the extremities, photosensitivity.

Interaction

When combined with other analgesic and anti-inflammatory drugs, the effect is enhanced. With simultaneous use with anticoagulants, drugs Li +, methotrexate, phenytoin, sulfonamides - increased side effects.

Overdose

Treatment: gastric lavage, symptomatic therapy.

Routes of administration

In / in (intravenously), in / m (intramuscularly), inside.

Precautions for Dexketoprofen

Caution should be exercised when appointing the elderly, children, with allergies, systemic connective tissue diseases and hematopoietic disorders. C are used with caution in conjunction with other analgesic and anti-inflammatory drugs, drugs that reduce blood clotting, lithium drugs, methotrexate, phenytoin and sulfonamides. It is not recommended to use during drivers' work vehicles and people whose profession is associated with increased concentration of attention.

Not intended for long-term treatment.

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