Instruction for use: Dexamethasone (Dexamethasonum)

Pharmacological group

Glucocorticosteroids

Ophthalmic products

Nosological classification (ICD-10)

A09 Diarrhea and gastroenteritis of allegedly infectious origin (dysentery, bacterial diarrhea)

Bacterial diarrhea, Bacterial dysentery, Bacterial infections of the digestive tract, Bacterial gastroenteritis, Diarrhea bacterial, Diarrhea or dysentery of amoebic or mixed etiology, Diarrhea of infectious genesis, Diarrhea on the background of antibiotic therapy, Traveler's Diarrhea, Travelers diarrhea due to changes in diet and habitual diet, Diarrhea due to antibiotic therapy, Dysenteric bacteriocarrier, Dysenteric enteritis, Dysentery, Dysentery bacterial, Dysentery mixed, Gastrointestinal infection, GI tract infections, Infectious diarrhea, Infectious Disease of the GI tract, Infection of the gastrointestinal tract, Infection of the biliary tract and gastrointestinal tract, GI tract infection, Summer diarrhea, Nonspecific acute diarrhea of infectious nature, Nonspecific chronic diarrhea of infectious nature, Acute bacterial diarrhea, Acute diarrhea in food poisoning, Acute dysentery, Acute bacterial gastroenteritis, Acute gastroenterocolitis, Acute Enterocolitis, Subacute dysentery, Diarrhea chronic, Refractory diarrhea in AIDS patients, Staphylococcal enteritis in children, Staphylococcal enterocolitis, Toxic diarrhea, Chronic dysentery, Enteritis, Enteritis infectious, Enterocolitis

A16 Tuberculosis of respiratory organs, not confirmed bacteriologically or histologically

A17.0 Tuberculous meningitis (G01 *)

Tuberculosis of serous membranes, Tuberculous meningitis, Meningitis tuberculosis

A48.3 Toxic shock syndrome

Bacteria-nomic shock, Infectious-toxic shock, intoxication syndrome, Toxic-infectious shock, Toxic shock, Chronic intoxication at diseases of the gastrointestinal tract, Chronic intoxication with gastrointestinal infections, endotoxin shock

C34 Malignant neoplasm of bronchi and lung

Small cell anaplastic lung tumors, Small cell and non-small cell lung cancer, Small cell lung cancer, Locally-distributed small cell lung cancer, Locally advanced non-small cell lung cancer, Undifferentiated lung cancer, Non-small cell lung cancer, Bronchogenic Cancer, Non-small cell lung cancer, Inoperable locally advanced non-small cell lung cancer, Cancer of the bronchi, Lungs' cancer, Small cell lung cancer, Lung cancer, Small cell lung cancer, Non-small cell lung cancer, Lung cancer of squamous cell,Recurrent non-small cell non-small cell lung cancer, Small cell lung carcinoma, Inoperable metastatic non-small cell lung cancer, Lung carcinoma, Ovsyocellular carcinoma of the lung, Disseminated lung cancer, Tumors of the lungs

C81 Hodgkin's disease [lymphogranulomatosis]

Paltauf-Sternberg disease, The generalized form of Hodgkin's disease, Lymphogranulomatosis, Hodgkin's disease, Hodgkin's lymphoma, Hodgkin's malignant lymphoma, Hodgkin's lymphoma, Lymphoproliferative diseases, Reticulosis fibromyaloid, Pelya-Ebstein fever

C82 Follicular [nodular] non-Hodgkin's lymphoma

Brill-Simmers disease, Malignant lymphoma, Hepatic Lymphoma, Recurrent non-Hodgkin's lymphoma, Follicular B-cell non-Hodgkin's lymphoma, Follicular lymphoma, Lymphoma of the liver

C83 Diffuse non-Hodgkin's lymphoma

Diffuse B-Large-Cell Non-Hodgkin's Lymphoma, Malignant lymphoma, Malignant lymphoma, especially of the histiocytic type, Lymphoblastic non-Hodgkin's lymphoma, Lymphoma non-Hodgkin's diffuse, Hepatic Lymphoma, Recurrence of lymphoma, Recurrent non-Hodgkin's lymphoma, Lymphoma of the liver

C85 Other and unspecified types of non-Hodgkin's lymphoma

Lymphoma of mixed type, Lymphomas from cells of the mantle zone, Malignant lymphoma, Lymphoma non-Hodgkin's disease, Lymphocytic lymphoma

C91 Lymphoid leukemia [lymphatic leukemia]

Lymphocytic leukemia, Lymphoproliferative diseases, Neuroleukemia, Refractory acute lymphoblastic leukemia, Refractory lymphoblastic leukemia, Transformation of preleukemias, Chronic lymphatic leukemia, Lymphoproliferative disorders

C92 Myeloid leukemia [myeloid leukemia]

Ph-positive chronic myelogenous leukemia, Granulocytic leukemia, Myeloid leukemia, Myeloid leukemia, Myeloma disease, Neuroleukemia, Acute myeloblastic leukemia, Acute non-lymphoblastic leukemia, Acute non-lymphoblastic leukemia in adults, Refractory acute non-lymphoblastic leukemia, Induction of remission in PMLL, Transformation of preleukemias, Subleukemic myelosis, Myeloblastic leukemia, Myeloid leukemia

D59.1 Other autoimmune hemolytic anemia

Autoimmune hemolytic anemia, Immune hemolytic anemia, Autoimmune hemolytic anemia

D60.9 Acquired pure red cell aplasia, unspecified

Hematopoietic disorders, Partial red cell aplasia of hematopoiesis, Erythroid anemia

D61.0 Constitutional aplastic anemia

Anemia hypoplastic

D61.9 Aplastic anemia, unspecified

Myelophthisis anemia, Anemia hypoplastic, Partial anemia, Aplasia of the bone marrow, Aplastic anemia, Congenital hypoplastic anemia, Bone marrow hypoplasia, Hypoplastic anemia, Hematopoietic disorders, Hereditary hypoplastic anemia, Normochromic-normocytic anemia

D69.3 Idiopathic thrombocytopenic purpura

Werlhof's disease, Idiopathic autoimmune thrombocytopenia, Idiopathic thrombocytopenic purpura of adults, Idiopathic thrombocytopenic purpura in adults, Immune idiopathic thrombocytopenic purpura, Immune thrombocytopenia, Bleeding in patients with thrombocytopenic purpura, Evans Syndrome, Thrombocytopenic purpura, Thrombocytopenia of immune origin, Chronic idiopathic thrombocytopenic purpura, Essential thrombocytopenia, Autoimmune thrombocytopenic purpura in pregnancy, Posttransfusion purpura

D69.5 Secondary thrombocytopenia

Secondary cytopenia

D70 Agranulocytosis

Agranulocytosis is hereditary, Aleicia, Aleykocytosis, Agranulocytic angina, Angina agranulocytic, Primary cytopenia

D86.0 Lung sarcoidosis

E05.5 Thyroid crisis or coma

thyrotoxic crisis, hypothyroid coma, Crease tireotoksicski

E06.1 Subacute thyroiditis

De Cherven's disease, De Kervena granulomatous goiter, Thyroiditis granulomatous giant cell

E27.1 Primary insufficiency of the adrenal cortex

Addison's Disease, Addisonism, Adrenocortical insufficiency, Hypofunction of the adrenal cortex, Collapse with Addison's Disease, Insufficiency of the adrenal cortex primary, Primary adrenocortical insufficiency, Primary adrenal insufficiency

E27.4 Other and unspecified adrenocortical insufficiency

Hypocorticism, Hypoaldosteronism, Adrenal insufficiency, Insufficiency of the adrenal cortex, Insufficiency of the adrenal cortex, Secondary adrenocortical insufficiency, Secondary adrenal insufficiency, Secondary insufficiency of the adrenal cortex, Temporary decrease in the function of the adrenal cortex, Dysfunction of the adrenal cortex

E27.8 Other specified disorders of the adrenal gland

E83.5.0 * Hypercalcemia

Hypercalcemic crisis, Idiopathic hypercalcemia of newborns, Milk-alkaline syndrome

E91 * Diagnosis of endocrine system diseases

Diagnosis of hypogalactia, Diagnosis of thyroid suppression, Diagnostic test of thyroid function, Diagnosis of hypothyroidism, Diagnosis of disorders of gonadotropic pituitary gland function, Thyroid scintigraphy test, Diagnostics of pheochromocytoma

G35 Multiple sclerosis

Disseminated sclerosis, multiple sclerosis, Relapsing Multiple Sclerosis, Secondary progressive multiple sclerosis, Exacerbation of multiple sclerosis, Mixed forms of multiple sclerosis

G93.6 Edema of the brain

Intraoperative cerebral edema, Cerebral edema, Post-traumatic swelling of the brain, Brain edema associated with radiation therapy, Brain edema associated with head trauma, Post-traumatic cerebral edema, Edema of the brain in poisoning

H01.0 Blepharitis

Blepharitis, Inflammation of the eyelids, Inflammatory diseases of the eyelids, Demodectic blepharitis, Superficial bacterial infection of the eyes, Superficial infection of the eye, Scaly blepharitis

H10.1 Acute atopic conjunctivitis

Allergic conjunctivitis, Allergic eye disease, Allergic conjunctivitis, Allergic conjunctivitis is caused by chemical and physical factors, Allergic rhinoconjunctivitis,Allergic inflammation of the eye, Spring catarrh, Spring keratitis, Spring conjunctivitis, allergic Conjunctivitis, Perennial allergic conjunctivitis,Exacerbation of pollen allergy in the form of Syndrome rinokonyunktivalnogo, Acute allergic keratoconjunctivitis, Acute allergic conjunctivitis,Superficial bacterial eye infections,rhinoconjunctivitis, Seasonal allergic conjunctivitis, Seasonal conjunctivitis, Sennoz, Chronic allergic keratoconjunctivitis, Chronic allergic conjunctivitis

H10.5 Blepharoconjunctivitis

Chronic Blepharoconjunctivitis, Blepharoconjunctivitis, Staphylococcal blepharoconjunctivitis

H10.9 Conjunctivitis, unspecified

Trahomny conjunctivitis, catarrhal conjunctivitis, Giperpapillyarny conjunctivitis, Non-infectious conjunctivitis, purulent conjunctivitis, Purulent conjunctivitis form, Year-round conjunctivitis, purulent conjunctivitis, Subacute conjunctivitis, Secondarily infected with conjunctivitis

H15.0 Sclerite

Acute scleritis, Chronic scleritis, Diffuse scleritis, Sclerite

H15.1 Episcleritis

Acute episcleritis, Chronic episcleritis

H16.0 Corneal ulcer

Allergic corneal ulcer, Erosion of the cornea, Regional ulcer, Purulent corneal ulcer,Corneal ulcer, Trophic ulcers of the cornea, Traumatic erosion of the cornea, Ulceration of the cornea, Keratitis with corneal ulceration, Ulcerative keratitis, Purulent corneal ulcers, Epithelial point keratitis, Ulceration of superficial corneal layers, Keratomalacia, Corneal ulcer, Recurrent erosions of the cornea, Recurrent ulcers of the cornea, Bacterial corneal ulcer, Septic ulcer of the cornea, Corneal edge ulcer

H16.2 Keratoconjunctivitis

Chronic allergic keratoconjunctivitis, Bacterial keratoconjunctivitis, Deep forms of adenovirus keratoconjunctivitis, Infectious conjunctivitis and keratoconjunctivitis caused by Chlamydia trachomatis, Acute allergic keratoconjunctivitis, Spring keratoconjunctivitis, Phlyctenular keratoconjunctivitis

H16.8 Other forms of keratitis

Allergic keratitis, Traumatic keratitis, Pannus

H20 Iridocyclitis

recurrent iritis, sympathetic iridocyclitis, Sluggish posterior uveitis, Sluggish posterior uveitis, Posterior uveitis, the posterior segment of the eye Iridocyclitis, Iridocyclitis and other uveitis, Irit, Keratoiridotsiklit, Acute iritis, uveitis, cycle of Acute iridocyclitis, Acute non-infectious uveitis

H30 Chorioretinal inflammation

Retinitis, Chorioretinitis, Central and peripheral chorioretinal dystrophy

H44.1 Other endophthalmitis

Ophthalmic sympathetic, Egyptian ophthalmia,Endophthalmitis

H46 Optic neuritis

Leber Retinitis, Inflammatory optic neuritis of the optic nerve, Strona syndrome, Inflammation of the optic nerve, Papillitis

H60 Otitis externa

Infections of ENT organs, Infections of the external auditory canal, Infectious-inflammatory diseases of the ear, Acute catarrhal inflammation of the external auditory canal, Infections of the external ear

H65 purulent otitis media

Inflammation of the middle ear

Allergic otitis media

I00 Rheumatic fever without mention of cardiac involvement

Acute rheumatism, Rheumatic arthritis acute, Rheumatism is active, Rheumatic fever, Acute attack of rheumatic joint disease

I01 Rheumatic fever with involvement of the heart

Rheumatic carditis acute

J18.9 Pneumonia, unspecified

Pneumonia in immunodeficiency states, Pneumonia with Legionnaires' Disease, Community-acquired pneumonia, Hospital-acquired pneumonia, Hospital pneumonia, Hospital pneumonia, Interstitial pneumonia, Respiratory infections, Non-pneumococcal pneumonia, Pneumonia

J30 Vasomotor and allergic rhinitis

Allergic rinopatiya, Allergic rhinosinusopathy, Allergic respiratory diseases, Allergic rhinitis, nasal allergy, Seasonal Allergic Rhinitis, Vasomotor rhinitis, Long-allergic rhinitis, Perennial allergic rhinitis, Perennial allergic rhinitis, Year-round or seasonal allergic rhinitis, Year-round allergic rhinitis nature, Rhinitis allergic vasomotor, Exacerbation of pollen allergy in the form of Syndrome rinokonyunktivalnogo, Acute allergic rhinitis, Edema of the nasal mucosa, Edema of the nasal mucosa, Swelling of the mucosa of the nasal cavity, Swelling of the nasal mucosa, Swelling of the nasal mucosa, pollen disease, Permanent allergic rhinitis, rhinoconjunctivitis, rhinosinusitis,rhinosinusopathy, Seasonal allergic rhinitis, Seasonal Allergic Rhinitis, Haymarket rhinitis, Chronic allergic rhinitis, Allergic respiratory diseases

J45 Asthma

Asthma physical effort, status asthmaticus, Bronchial asthma, Asthma lung flow, Bronchial asthma with obstruction of sputum discharge, Bronchial asthma heavy currents, Bronchial asthma physical effort, hypersecretory asthma, Hormone-dependent form of bronchial asthma, Relief of asthma attacks in bronchial asthma, Non-allergic asthma, nocturnal asthma, Exacerbation of asthma, Asthma attacks, Endogenous forms of asthma, Night asthma, Cough with bronchial asthma

J46 Status asthmaticus

Asthmatic attack, status asthmaticus, Bronchospasm in bronchial asthma

J63.2 Berylliosis

J69.0 Pneumonitis caused by food and vomit

Aspiration pneumonia, Pneumonia aspiration, Postoperative aspiration pneumonia in neurosurgical and thoracic operations

J82 Pulmonary eosinophilia, not elsewhere classified

Pulmonary infiltrate, Eosinophilic pulmonary infiltrate, Leffler's syndrome, Leffler's disease

J84.9 Interstitial pulmonary disease, unspecified

K50 Crohn's disease [regional enteritis]

Crohn's disease, Crohn's disease with fistula, Granuloma of the intestine, Granulomatous enteritis, Crohn's disease, Regional ileitis, Terminal Ileitis, Enteritis regional

K51 Ulcerative colitis

Colitis acute ulcerative, Colitis ulcerative, Ulcerative-necrotic colitis, Colitis ulcerative-hemorrhagic nonspecific, Colitis ulcerative and trophic, Colitis ulcerative idiopathic, Colitis ulcerative nonspecific, Nonspecific ulcerative colitis, Proctocolitis ulcers, Hemorrhagic purulent rectoxitis, Rectoccolitis ulcerative-hemorrhagic

K72.9 Hepatic insufficiency, unspecified

Latent hepatic encephalopathy, Acute liver failure, Liver failure, Hepatic precoma, Acute hepatic-renal failure

K73.9 Chronic hepatitis, unspecified

Chronic hepatitis, Chronic hepatitis with signs of cholestasis, Inflammatory liver disease, Infection of the liver, Chronic reactive hepatitis, Chronic inflammatory liver disease, Hepatitis chronic

L10 Pemphigus [pemphigus]

Benign pemphigoid of mucous membranes, Bubble dermatosis, Pemphigus, Dermatitis, vesicular, Benign pemphigus, Ordinary pemphigus, Pemphigus, Bubble dermatitis, Family benign pemphigus Hailey-Hailey

L13.9 Bullous changes, unspecified

Bullous dermatitis

L20 Atopic dermatitis

Itchy atopic eczema, Common neurodermatitis, Allergic skin diseases, Allergic skin diseases of non-infectious etiology, Allergic skin diseases of non-microbial etiology, Allergic skin diseases, Allergic skin lesions, Allergic manifestations on the skin, Allergic dermatitis, Allergic diathesis, Allergic itching dermatosis, Allergic Skin Disease, Allergic skin irritation, Dermatitis allergic, Atopic dermatitis, Dermatosis allergic, Diathesis exudative, Skin Allergic Disease, Skin allergic reaction to medicinal and chemical preparations, Skin reaction to medication, Skin and allergic disease, Acute eczema, Chronic atopic dermatitis, Exudative diathesis, Itching allergic dermatosis

L21 Seborrheic dermatitis

Dermatitis seborrheic, Increased sebum separation, Seborrheic Eczema, Seborrheic dermatitis of the scalp, Seborrheic pyodermatitis, Seborrhea, Eczema seborrheic

L25.9 Unspecified contact dermatitis, cause not specified

L26 Exfoliative dermatitis

Dermatitis exfoliative, Exfoliative dermatitis generalized

L30.9 Dermatitis, unspecified

Allergic dermatoses complicated by a secondary bacterial infection, Anal eczema, Bacterial maturation, Varicose Eczema, Venous dermatitis, Inflammation of the skin, Inflammation of the skin upon contact with plants, Inflammatory Skin Diseases, Inflammatory skin reactions, Inflammatory processes of the skin, Hypostatic dermatitis, Fungal Eczema, Fungal dermatosis, Dermatitis, Dermatitis is stagnant, Dermatitis and eczema in the anal area, Dermatitis acute contact, Perianal dermatitis, Dermatosis, Dermatosis of the scalp, Dermatosis of psoriasis, Dermatosis with persistent itching, Dermatoses, Dermatoses itchy, Other itching dermatoses, Significant eczematous manifestations, Itching with, dermatoses, Itching eczema, True eczema, Skin reaction to insect bites,Skin itching with dermatosis, Constitutional eczema, Weeping eczema, Drowsing inflammatory skin disease, Dying Infectious-Inflammatory Skin Disease, Non-allergic dermatitis, Nummular eczema, Acute contact eczema, Acute inflammatory skin disease, Acute dermatosis, Acute severe dermatosis, Perianal dermatitis, Superficial dermatosis, Subacute Contact Eczema, Simple dermatitis, Occupational dermatitis, Psychogenic dermatosis, Bubble dermatitis of newborns, Pustular eruptions, Irritation and redness of the skin, Low-flammable eczema, Dry atrophic eczema, Dry eczema, Toxic dermatitis, Ear eczema like dermatitis, Chronic eczema, Chronic dermatosis, Chronic common dermatosis, Scaly papular dermatosis, Eczema, Eczema anal region, Eczema of the hands, Eczema Contact, Eczema lichenized, Eczema Nummular, Eczema acute, Eczema acute contact, Eczema subacute, Eczematous dermatitis, Eczema-like rashes, Ecome exogenous, Endogenous eczema, Gluteal dermatitis, Restricted itchy dermatitis

L40 Psoriasis

Chronic psoriasis with diffuse plaques, Generalized psoriasis, Psoriasis of the scalp, Psoriasis of the scalp, Generalized form of psoriasis, Psoriasis dermatitis, Psoriasis complicated by erythroderma, Invalidative psoriasis, Isolated psoriatic plaque, Exfoliative psoriasis, Psoriatic Erythroderma, Psoriasis with eczematosis, Hyperkeratosis in psoriasis,Inverse psoriasis,Psoriasis eczematous, Dermatosis of psoriasis, Psoriasis of the genitals, Psoriasis with lesions of hairy areas of skin, Erythrodermal psoriasis, Chronic psoriasis of the scalp, Chronic psoriasis, Ordinary psoriasis, Refractory psoriasis, Kebner phenomenon, Scaly lichen

L40.5 Arthropathy psoriasis (M07.0-M07.3 *, M09.0 *)

Arthritis psoriatic, Arthropathic form of psoriasis

L50 Urticaria

Idiopathic chronic urticaria, Injury Urticaria, Chronic urticaria, Hives of the newborn

L51.2 Toxic epidermal necrolysis [Lyell's]

Lyell's Syndrome, Toxic epidermal necrolysis

L98.8 Other specified diseases of skin and subcutaneous tissue

Favre-Canculo disease, Interdigital erosion, Ultrasonic cystic skin elastosis with comedones, Benign skin change

M02.3 Reiter's Disease

Reiter's syndrome, Arthritis is infectious-allergic, Arthritis Reactive, Urethro-oculo-synovial syndrome

M06.1 Still's disease, developed in adults

Still's disease, Still's syndrome

M06.9 Other specified rheumatoid arthritis

Rheumatoid arthritis,Pain syndrome in rheumatic diseases, Pain in rheumatoid arthritis, Inflammation in rheumatoid arthritis, Degenerative forms of rheumatoid arthritis, Children's rheumatoid arthritis, Exacerbation of rheumatoid arthritis, Acute articular rheumatism, Rheumatic arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatoid arthritis of active course, Rheumatoid arthritis, Rheumatoid polyarthritis, Acute rheumatoid arthritis, Acute rheumatism

M08 Juvenile [juvenile] Arthritis

Juvenile arthritis, Juvenile chronic polyarthritis, Juvenile chronic arthritis, Juvenile rheumatoid arthritis, Arthritis juvenile chronic

M10.0 Idiopathic Gout

Primary gout

M13.0 Unspecified polyarthritis

Polyarthritis, Inflammatory diseases of joints, Nonspecific polyarthritis, Exchange polyarthritis, Polyarthritis, Polyarthropathy, Subchronic polyarthritis, Chronic polyarthritis, Pain with osteoarthritis, Polyarthritis of unclear etiology

M19.9 Arthrosis, unspecified

Change in brush with osteoarthritis, Osteoarthritis, Osteoarthrosis, Arthrosis of large joints, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Deforming arthrosis, Deforming osteoarthritis, Deforming osteoarthritis of joints, Osteoarthritis in the acute stage, Osteoarthritis of large joints, Acute pain syndrome with osteoarthritis, Post-traumatic osteoarthritis, Rheumatic osteoarthritis, Spondylarthrosis, Chronic osteoarthritis

M30.0 Nodular polyarteritis

Periarteritis nodosa, Nodular periarteritis, Nodular polyarteritis (periarteritis)

M32 Systemic lupus erythematosus

Lupus erythematosus red disseminated, Disseminated lupus erythematosus, Chronic lupus erythematosus

M33.2 Poliomyositis

Muscle weakness in polymyositis, Polymyositis in children, Polyartralgia in polymyositis

M34.9 Systemic sclerosis, unspecified

Systemic scleroderma

M45 Ankylosing spondylitis

Ankylosing spondylarthrosis, Marie-Strumpel disease, Ankylosing spondylitis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Bechterew's disease, Ankylosing spondylitis, Diseases of the spinal column, Rheumatic spondylitis, Bechterew-Marie-Strumpel disease

M65.9 Synovitis and tendosynovitis, unspecified

Synovitis, Inflammation of the tendon sheath, Acute nonspecific tenosynovitis, Reactive synovitis

M67.9 Lesion of synovium and tendon, unspecified

Inflammation of the tendons, Inflammation of ligaments, Inflammation of tendons with injuries, Inflammation of tendons

M71.9 Bursopathy, unspecified

Bursites, Alberta disease, Acute bursitis

M75.0 Adhesive shoulder capsulitis

Acute shoulder-scapular periarthritis, Duplay's disease, Duplay Syndrome, Frozen shoulder, Shoulder-shoulder periarthritis, Periarteritis humeroscapular, Shoulder periarthritis, Pleiraptocular periarthritis, Capsule, Frozen shoulder

M77.9 Other unspecified

Capsule, Periarthritis, Tendonitis, Tendopathy, Periarthropathy

N00 Acute nephritic syndrome

Glomerulonephritis acute, Jade sharp, Disease with minimal changes, Disease of minimal changes, Rapidly progressive glomerulonephritis, Nephrotic syndrome with damage to small legs of podocytes, Acute nephritic syndrome,Acute glomerulonephritis

N04 Nephrotic syndrome

Nephrosis, Edema of the kidneys, Nephrotic syndrome, Lipoid nephrosis, Nephrotic syndrome without uremia, Acute nephrotic syndrome, Edematic syndrome of renal genesis, Renal form of diabetes insipidus, Segmental glomerulonephritis, Focal glomerulonephritis, Family Nephrotic Syndromes, Chronic nephrotic proteinuric syndrome, Lipiduria, Jade hereditary, Nephrotic-proteinuric syndrome

R11 Nausea and vomiting

Postoperative vomiting, Nausea, vomiting, Vomiting in the postoperative period, Vomiting drug, Vomiting on the background radiation therapy, Vomiting indomitable, Vomiting with radiation therapy, persistent vomiting, anacatharsis, Postoperative nausea, Vomiting during chemotherapy, Vomiting of central origin, Vomiting on the background of cytostatic chemotherapy, persistent hiccups, repeated vomiting

R21 Rashes and other nonspecific skin rashes

Skin rash, Skin and mucous eruptions, Skin rashes, Drug rash, Medicinal rash fixed, Dry skin rashes, Rash, Toxidermia, Toxicoderma, Toxic rash, Korepodobnye rashes from drugs, Maculo-papular rashes, Drug-induced rash

R57.0 Cardiogenic shock

cardiogenic shock

R57.8.0 * Burn shock

Pain shock with burns, Burn shock

S05.0 Injury of the conjunctiva and corneal abrasion without mention of the foreign body

Superficial injury of the cornea, Corneal surface damage, Traumatic erosion of the cornea, Mechanical injuries of the cornea

S05.9 Injury of unspecified part of the eye and orbit

eye injury, Superficial corneal injury

T49.8 Poisoning by other topical agents

T78.0 Anaphylactic shock caused by a pathological reaction to food

T78.1 Other manifestations of a pathological reaction to food

Allergic reactions to food, Allergy to cow's milk proteins, Allergy to proteins of mother's milk, Food Allergy, Artificial feeding of children from birth with intolerance to cow's milk proteins, Multiple food allergies, Disturbance of assimilation of milk food, Disturbance of food assimilation, Intolerance to cow's milk protein in infants, Intolerance to cow's milk proteins, Intolerance to cow milk, Intolerance to certain foods, Food allergy, Food and drug allergies, Food intolerance, Bowel irritation from food

T78.2 Anaphylactic shock, unspecified

Anaphylactic shock, Anaphylactoid reaction, Anaphylactic shock, Anaphylactic reactions, Anaphylactic shock to drugs

T78.3 Angioedema

Edema Quincke, Laryngeal exacerbation with angioneurotic edema, Recurrent angioedema, Allergic edema, Recurrent swelling of Quincy

T78.4 Allergy, unspecified

Allergic reactions to insulin, Allergic reactions to insect stings, Allergic reactions similar to systemic lupus erythematosus, Allergic diseases, Allergic diseases of mucous membranes, Allergic diseases and conditions resulting from increased release of histamine, Allergic diseases of mucous membranes, Allergic symptoms, Allergic symptoms in the mucous membranes, Allergic reactions, Allergic reactions caused by insect bites, Allergic reactions, Allergic conditions, Allergic laryngeal edema, allergopathy, allergic conditions, Allergy, House dust allergy, Anaphylaxis, Cutaneous reactions to medications, Skin reaction to insect stings, Cosmetic allergy, Drug allergy, Acute allergic reaction, Laryngeal edema allergic genesis and background radiation, Food and drug allergy

T79.4 Traumatic shock

Hemorrhagic shock, Crush syndrome, hemorrhagic shock, postoperative shock, post-traumatic shock, traumatic shock, hemorrhagic shock and encephalopathy syndrome

T80.6 Other serum reactions

Serum sickness, Allergic reaction of the type of serum sickness, Serous disease accelerated

T81.1 Shock during or after the procedure, not elsewhere classified

Operating shock, Postoperative shock, Operational shock

Y57 Adverse reactions in the therapeutic use of other and unspecified drugs and medications

Z94 Presence of the transplanted organ and tissue

Allogeneic transplantation, Allotransplantation, Autotransplantation, Gomotransplant, Isotransplantation, Transplantation, Orthotopic transplantation

Code CAS50-02-2

Characteristics

Hormonal (a glucocorticoid for systemic and topical application). Fluorinated hydrocortisone homolog.

Dexamethasone is a white or almost white crystalline powder, odorless. Solubility in water (25 ° C): 10 mg / 100 mL; Soluble in acetone, ethanol, chloroform. Molecular weight 392.47.

Dexamethasone sodium phosphate is a white or slightly yellow crystalline powder. Easily soluble in water and very hygroscopic. Molecular weight 516.41.

Pharmacology

Pharmacological action - anti-inflammatory, antiallergic, immunosuppressive, anti-shock, glucocorticoid.

Interacts with specific cytoplasmic receptors and forms a complex that penetrates into the nucleus of the cell; Induces mRNA expression or depression, altering the formation of proteins on the ribosomes, incl. Lipocortin, mediating cellular effects. Lipocortin depresses phospholipase A2, suppresses the liberation of arachidonic acid and inhibits the biosynthesis of endoperexides, PG, leukotrienes, contributing to inflammation, allergy, etc. Prevents the release of inflammatory mediators from eosinophils and mast cells. It inhibits the activity of hyaluronidase, collagenase and proteases, normalizes the functions of the intercellular matrix of the cartilaginous and bone tissue. Reduces the permeability of capillaries, stabilizes cell membranes, incl. Lysosomal, inhibits the release of cytokines (interleukin 1 and 2, gamma-interferon) from lymphocytes and macrophages. Affects all phases of inflammation, antiproliferative effect is due to inhibition of migration of monocytes to the inflammatory focus and proliferation of fibroblasts. Causes the involution of lymphoid tissue and lymphopenia, which causes immunodepression. In addition to reducing the number of T-lymphocytes, their effect on B-lymphocytes decreases and immunoglobulin production is inhibited. The effect on the complement system is to reduce the formation and increase the decay of its components. Antiallergic effect is a consequence of inhibition of synthesis and secretion of mediators of allergy and a decrease in the number of basophils. Restores the sensitivity of adrenoreceptors to catecholamines. Accelerates protein catabolism and reduces their content in plasma, reduces the utilization of glucose by peripheral tissues and increases gluconeogenesis in the liver. Stimulates the formation of enzyme proteins in the liver, surfactant, fibrinogen, erythropoietin, lipomodulin. It causes a redistribution of fat (increases fat lipolysis of limbs and fat deposition in the upper half of the trunk and on the face). Promotes the formation of higher fatty acids and triglycerides. Reduces absorption and increases excretion of calcium; Retards sodium and water, secretion of ACTH (adrenocorticotropic hormone). Has anti-shock effect.

After oral administration, it is quickly and completely absorbed from the digestive tract (gastrointestinal tract), Tmax - 1-2 hours. Blood is bound (60-70%) with a specific transporter protein - transcortin. Easily passes through the histohematological barriers, including the BBB (blood-brain barrier) and placental barrier. Biotransformiruetsya in the liver (mainly by conjugation with glucuronic and sulfuric acids) to inactive metabolites. T1 / 2 from the plasma - 3-4.5 h, T1 / 2 of the tissues - 36-54 h. It is excreted by the kidneys and through the intestine, it penetrates into the breast milk.

After instillation into the conjunctival sac, it penetrates well into the epithelium of the cornea and conjunctiva, and therapeutic concentrations of drugs (drug) are created in the aqueous humor of the eye. With inflammation or damage to the mucous membrane, the penetration rate increases.

Indications

For systemic use (parenteral and oral)

Shock (burn, anaphylactic, post-traumatic, postoperative, toxic, cardiogenic, hemotransfusion, etc.); Cerebral edema (including tumors, craniocerebral trauma, neurosurgical intervention, cerebral hemorrhage, encephalitis, meningitis, radiation injury); Bronchial asthma, asthmatic status; Systemic connective tissue diseases (including systemic lupus erythematosus, rheumatoid arthritis, scleroderma, nodular periarteritis, dermatomyositis); Thyrotoxic crisis; Hepatic coma; Poisoning with cauterizing fluids (to reduce inflammation and prevent cicatricial narrowing); Acute and chronic inflammatory diseases of the joints, incl. Gouty and psoriatic arthritis, osteoarthritis (including post-traumatic), polyarthritis, humeroscapular periarthritis, ankylosing spondylitis (Bechterew's disease), juvenile arthritis, Still's syndrome in adults, bursitis, nonspecific tenosynovitis, synovitis, epicondylitis; Rheumatic fever, acute rheumatic heart disease; Acute and chronic allergic diseases: allergic reactions to drugs and food, whey, urticaria, allergic rhinitis, pollinosis, angioedema, drug exanthema; Skin diseases: pemphigus, psoriasis, dermatitis (contact dermatitis with large skin surface lesions, atopic, exfoliative, bullous herpetiform, seborrheic, etc.), eczema, toxicermy, toxic epidermal necrolysis (Lyell's syndrome), malignant exudative erythema (Stevens-Johnson syndrome ); Allergic eye diseases: allergic corneal ulcers, allergic forms of conjunctivitis; Inflammatory eye diseases: sympathetic ophthalmia, severe sluggish anterior and posterior uveitis, optic neuritis; Primary or secondary adrenal insufficiency (including the condition after removal of the adrenal glands); Congenital adrenal hyperplasia; Kidney disease of autoimmune genesis (including acute glomerulonephritis), nephrotic syndrome; Subacute thyroiditis; Diseases of the hematopoiesis: agranulocytosis, panmyelopathy, anemia (including autoimmune hemolytic, congenital hypoplastic, erythroblastopenia), idiopathic thrombocytopenic purpura, secondary thrombocytopenia in adults, lymphoma (Hodgkin's, non-Hodgkin's), leukemia, lymphatic leukemia (acute, chronic); Lung diseases: acute alveolitis, pulmonary fibrosis, sarcoidosis II-III; Tuberculosis meningitis, pulmonary tuberculosis, aspiration pneumonia (only in combination with specific therapy); Berylliosis, Leffler's syndrome (resistant to other therapies); Lung cancer (in combination with cytostatics); multiple sclerosis; Diseases of the digestive tract (for removing the patient from a critical condition): ulcerative colitis, Crohn's disease, local enteritis; hepatitis; Prevention of graft rejection reaction; Tumor hypercalcemia, nausea and vomiting during cytostatic therapy; Myeloma; Conducting a sample in the differential diagnosis of hyperplasia (hyperfunction) and tumors of the adrenal cortex.

For topical application

Intra-articular, periarticular. Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Reiter's disease, osteoarthritis (in the presence of pronounced signs of joint inflammation, synovitis).

Conjunctival. Conjunctivitis (non-nasal and allergic), keratitis, keratoconjunctivitis (without epithelial damage), iritis, iridocyclitis, blepharitis, blepharoconjunctivitis, episcleritis, scleritis, uveitis of various genesis, retinitis, optic neuritis, retrobulbar neuritis, superficial injuries of the cornea of various etiologies Cornea), inflammatory processes after eye injuries and eye operations, sympathetic ophthalmia.

In the external auditory canal. Allergic and inflammatory diseases of the ear, incl. otitis.

Contraindications

Hypersensitivity (for short-term systemic use according to vital indications is the only contraindication).

For systemic use (parenteral and oral). Systemic mycoses, parasitic and infectious diseases of a viral or bacterial nature (currently without appropriate chemotherapy or recently transferred, including recent contact with the patient), incl. Herpes simplex, herpes zoster (viremic phase), chicken pox, measles, amebiasis, strongyloidiasis (established or suspected), active forms of tuberculosis; Immunodeficiency states (including AIDS or HIV infection), the period before and after preventive vaccinations (especially antiviral); Systemic osteoporosis, myastenia gravis; Gastrointestinal diseases (including peptic ulcer of stomach and duodenum, esophagitis, gastritis, acute or latent peptic ulcer, newly created intestinal anastomosis, ulcerative colitis with perforation or abscessing threat, diverticulitis); Diseases of the cardiovascular system, incl. Recently suffered myocardial infarction, congestive heart failure, hypertension; Diabetes mellitus, acute renal and / or hepatic insufficiency, psychosis.

For intraarticular administration. Unstable joints, previous arthroplasty, pathological hemorrhage (endogenous or caused by the use of anticoagulants), transosustavnoy bone fracture, infected foci of joints, periarticular soft tissues and intervertebral spaces, expressed near-osteoporosis.

Eye forms. Viral, fungal and tubercular lesions of the eyes, incl. Keratitis caused by Herpes simplex, viral conjunctivitis, acute purulent ocular infection (in the absence of antibiotic therapy), violation of the integrity of the epithelium of the cornea, trachoma, glaucoma.

Ear forms. Perforation of the tympanic membrane.

Restrictions for use

For systemic use (parenteral and oral): Itenko-Cushing's disease, grade III-IV obesity, convulsive conditions, hypoalbuminemia and conditions predisposing to its occurrence; Open angle glaucoma.

For intraarticular administration: the general severe condition of the patient, ineffectiveness or short-term effect of the two previous administrations (taking into account the individual properties of the glucocorticoids used).

pregnancy and lactation

The use of corticosteroids during pregnancy is possible if the expected effect of therapy exceeds the potential risk to the fetus (adequate and strictly controlled safety studies have not been conducted). Women of childbearing age need to be warned about the potential risk to the fetus (corticosteroids pass through the placenta). Care must be taken to monitor newborns whose mothers received corticosteroids during pregnancy (possibly developing adrenal insufficiency in the fetus and newborn).

The teratogenicity of dexamethasone in mice and rabbits after local ophthalmic applications of multiple therapeutic doses is shown.

In mice, corticosteroids cause fetal resorption and a specific disorder - the development of the wolf mouth in the offspring. In rabbits, corticosteroids cause fetal resorption and multiple disorders, including. Anomalies in the development of the head, ear, limbs, palate, etc.

The action category for fetus by FDA is C.

It is recommended that breastfeeding women stop breastfeeding or using drugs, especially in high doses (corticosteroids penetrate breast milk and can suppress growth, the production of endogenous corticosteroids and cause undesirable effects in the newborn).

It should be borne in mind that with topical application of glucocorticoids, systemic absorption occurs.

Side effects

The frequency of development and severity of side effects depend on the duration of the application, the amount of dose used and the possibility of observing the circadian rhythm of prescribing drugs (medicinal product).

System Effects

From the side of the nervous system and sensory organs: delirium (confusion, excitement, anxiety), disorientation, euphoria, hallucinations, manic / depressive episode, depression or paranoia, increased intracranial pressure with the congestion syndrome of the optic nerve (pseudotumor brain - more often in children, Usually after too rapid reduction of the dose, symptoms - headache, deterioration of visual acuity or double vision); Sleep disturbance, dizziness, vertigo, headache; Sudden loss of vision (with parenteral administration in the head, neck, nasal concha, scalp), formation of posterior subcapsular cataract, increased intraocular pressure with possible damage to the optic nerve, glaucoma, steroid exophthalmus, development of secondary fungal or viral infections of the eyes.

From the cardiovascular system and blood (hematopoiesis, hemostasis): arterial hypertension, the development of chronic heart failure (in predisposed patients), myocardial dystrophy, hypercoagulation, thrombosis, ECG changes characteristic of hypokalemia; With parenteral administration: tides of blood to the face.

From the digestive tract: nausea, vomiting, erosive and ulcerative lesions of the gastrointestinal tract, pancreatitis, erosive esophagitis, hiccups, increased / decreased appetite.

From the metabolism: the delay of Na + and water (peripheral edema), hypokalemia, hypocalcaemia, negative nitrogen balance due to protein catabolism, weight gain.

On the part of the endocrine system: suppression of adrenal cortex function, decreased glucose tolerance, steroid diabetes mellitus or manifestation of latent diabetes mellitus, Itenko-Cushing syndrome, hirsutism, irregular menstruation, growth retardation in children.

From the musculoskeletal system: muscle weakness, steroid myopathy, muscle mass reduction, osteoporosis (including spontaneous bone fractures, aseptic necrosis of the head of the femur), tendon rupture; Pain in the muscles or joints, back; With intra-articular injection: increased pain in the joint.

From the skin: steroid acne, striae, thinning of the skin, petechiae and ecchymosis, delayed healing of wounds, increased sweating.

Allergic reactions: skin rash, hives, swelling of the face, stridor or shortness of breath, anaphylactic shock.

Other: decreased immunity and activation of infectious diseases, withdrawal syndrome (anorexia, nausea, blocking, abdominal pain, general weakness, etc.).

Local reactions with parenteral administration: burning, numbness, pain, paresthesia and infection at the injection site, scar formation at the injection site; Hyper or hypopigmentation; Atrophy of the skin and subcutaneous tissue (with / m (intramuscular) administration).

Eye forms: prolonged use (more than 3 weeks) may increase intraocular pressure and / or the development of glaucoma with optic nerve damage, reduced visual acuity and loss of visual fields, formation of posterior subcapsular cataract, thinning and perforation of the cornea; Possible spread of herpetic and bacterial infection; In patients with hypersensitivity to dexamethasone or benzalkonium, chloride may develop conjunctivitis and blepharitis.

Local reactions (when using ophthalmic and / or ear forms): irritation, itching and burning of the skin; dermatitis.

Interaction

Reduces the therapeutic and toxic effects of barbiturates, phenytoin, rifampicin (accelerate metabolism), somatotropin, antacids (reduce absorption), increase - estrogen-containing oral contraceptives, the risk of arrhythmias and hypokalemia - cardiac glycosides and diuretics, the likelihood of edema and hypertension - sodium-containing drugs or supplements, Severe hypokalemia, heart failure and osteoporosis - amphotericin B and inhibitors of carbonic anhydrase, risk of erosive and ulcerative lesions and bleeding from the gastrointestinal tract (gastro-intestinal tract (NSAIDs) (non-steroidal anti-inflammatory drugs).

When used simultaneously with live antiviral vaccines and against other types of immunization, it increases the risk of virus activation and the development of infections. Weaken the hypoglycemic activity of insulin and oral antidiabetics, anticoagulant - coumarins, diuretic - diuretic, immunotropic - vaccination (suppresses antibody formation). It worsens the tolerance of cardiac glycosides (causes potassium deficiency), reduces the concentration of salicylates and praziquantel in the blood.

Overdose

Symptoms: increased side effects.

Treatment: with the development of adverse events - symptomatic therapy, with Isenko-Cushing syndrome - the appointment of aminoglutethimide.

Routes of administration

Inside, parenterally, topically, incl. Conjunctivally.

Precautions

The appointment in case of intercurrent infections, tuberculosis, septic conditions requires preliminary and subsequent simultaneous antibiotic therapy.

It is necessary to take into account the increased effect of corticosteroids in hypothyroidism and liver cirrhosis, the aggravation of psychotic symptoms and emotional lability at their high initial level, the masking of some symptoms of infections, the likelihood of maintaining a relative adrenal insufficiency for several months (after one year) after dexamethasone withdrawal (especially in the case of prolonged use ).

In stressful situations during maintenance treatment (for example, surgery, illness, trauma), you should adjust the dose of the drug due to the increased need for glucocorticoids.

With a long course carefully monitor the dynamics of growth and development of children, systematically conduct ophthalmological examinations, monitor the condition of the hypothalamic-pituitary-adrenal system, the level of glucose in the blood.

In connection with the possible occurrence of anaphylactic reactions during parenteral therapy, all precautions should be taken before the administration of the drug (especially in patients with a tendency to drug allergies).

Stop therapy only gradually. With sudden cancellation after long-term treatment, it is possible to develop withdrawal syndrome, manifested by increased body temperature, myalgia and arthralgia, malaise. These symptoms can appear even in the case when there is no insufficiency of the adrenal cortex.

It is recommended to be cautious in carrying out any kind of operations, the occurrence of infectious diseases, trauma, avoid immunization, and eliminate the use of alcoholic beverages. In children, in order to avoid an overdose, it is better to calculate the dose based on the surface area of the body. In case of contact with sick measles, chicken pox and other infections, appropriate preventive therapy is prescribed.

Before using the eye forms of dexamethasone, soft contact lenses should be removed (they can be re-installed no earlier than 15 minutes). During treatment, the condition of the cornea should be monitored and the intraocular pressure measured.

Do not use during work drivers of vehicles and people whose profession is associated with increased concentration of attention.