Instruction for use: Decapeptyl
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ATX Code L02AE04 Triptorelin
Active substance: Triptorelin
Pharmacological group
Hormones of the hypothalamus, pituitary gland, gonadotropins and their antagonists
Antineoplastic hormonal agents and hormone antagonists
Nosological classification (ICD-10)
C61 Malignant neoplasm of prostate
Adenocarcinoma of the prostate, Hormone-dependent prostate cancer, Hormone-Resistant Prostate Cancer, Malignant tumor of prostate, Malignant neoplasm of prostate, Carcinoma of the prostate, Locally-distributed non-metastatic prostate cancer, Locally advanced prostate cancer, Locally spread prostate cancer, Metastatic prostatic carcinoma, Metastatic prostate cancer, Metastatic hormone-resistant prostate cancer, Non-metastatic prostate cancer, Incompatible prostate cancer, Prostate Cancer, Prostate cancer, Common prostate cancer, Testosterone-Depot Prostate Cancer
D26 Other benign neoplasms of the uterus
Fibromyoma of the uterus, Myoma, Uterine fibroids, Fibromyoma, Myoma of the uterus, Fibrrios, Meigs syndrome, Tumors of the uterus
N80 Endometriosis
Endometrioid endometriosis
N91 Lack of menstruation, meager and rare menstruation
Amenorrhea, Amenorrhea hypogonadotropic, Amenorrhea is prolactin-dependent, Oligomenorrhoea, Shortening of the secretory phase of the menstrual cycle, Menstrual disorders, Menstruation disorders, Prolactin-dependent amenorrhea without galactorrhea
N97 Female infertility
Female infertility in anovulation, Hyperprolactinemic infertility, Hyperprolactinaemia with infertility, Endocrine infertility, Infertility due to hypothalamic-pituitary dysfunction, Infertility infertility, Infertility, Infertility on the background of hyperprolactinaemia, Functional infertility, Marriage is infertile, Infertility of ovarian genesis, Stimulation of the growth of a single follicle
Z31.1 Artificial insemination
Fence of egg, ICSI (Intra Cytoplasmic Sperm Injection), Controlled ovarian stimulation, Controlled superovulation, Controlled superovulation in artificial insemination, Treatment of insemination, Fertilization artificial, Premature ovulation, The IVF program, The program of in vitro fertilization, Superovulation
Composition and form of release
Solution for injection 1 ml
Tryptorelin acetate 105 μg
(Corresponding to 95.6 μg of triptorelin)
Triptorelin acetate 525 μg
(Corresponding to 478.1 μg of triptorelin)
Auxiliary substances: sodium chloride; Glacial acetic acid; water for injections
In disposable syringes of 1 ml each; In a box of 7 syringes.
pharmachologic effect
Pharmacological action - antitumor, cytostatic, antigonadotropic.
Daily injections of Decapeptal initially cause stimulation of pituitary secretion of LH and FSH. After a period of stimulation, the desensitisation of the pituitary gland develops, the level of gonadotropins decreases, which leads to a decrease in the concentration of sex hormones in the blood before the postastrational level. The effect is reversible.
Indications
IVF program (in vitro fertilization), endometriosis, uterine myoma, prostate cancer, hypogonadotropic amenorrhea.
Contraindications
Hypersensitivity, pregnancy.
pregnancy and lactation
Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.
Side effects
Associated with a decrease in the level of sex hormones in the blood: a decrease in libido, mood lability, depression, hot flashes, insignificant demineralization of bones (without increased fragility), local allergic reactions (hyperemia, itching at the injection site).
Dosing and Administration
Treatment of infertility in women by IVF.
1. Decapeptil 0.1 mg sc / 1 ml / day daily from 21 days of the menstrual cycle preceding the treatment, until the introduction of chorionic gonadotropin (hCG). At the same time from 3 days of the medical menstrual cycle, the hMG preparation is introduced (for example - Menogon). The drug hCG is administered for 34-36 h before the planned puncture of the follicles.
2. Decapeptil 0.5 mg sc 1 ml / day daily from 21 days of the menstrual cycle preceding the treatment (up to 3 days of the treatment cycle). Dekapeptil 0.1 mg sc / 1 ml / day from 3 days of the treatment cycle until the administration of the drug hCG. At the same time from 3 days of the medical menstrual cycle, the hMG preparation is introduced (for example - Menogon). The drug hCG is administered for 34-36 h before the planned puncture of the follicles.
3. Decapeptil 0.1 mg c / c from 1 day of the treatment menstrual cycle daily until the administration of hCG. At the same time from 2 days of the medical menstrual cycle, the hMG preparation is introduced (for example - Menogon). The drug hCG is administered for 34-36 h before the planned puncture of the follicles.
Uterine fibroids, endometriosis, prostate carcinoma: subcutaneously, once a day; At the beginning of the course of treatment, within 7 days - Decapeptil 0.5 mg to 1 ml / day, starting from the 8th day of treatment - Dekapeptil 0.1 mg to 1 ml / day (maintenance dose). The injection site should be changed.
For a prolonged course of treatment, it is recommended to use Decapeptil Depot - 1 injection every 28 days.
Storage Conditions
In a dry place, at a temperature of 2-8 ° C.
Keep out of the reach of children.
Shelf-life
3 years.
Do not use after the expiry date printed on the package.