Instruction for use: Danol
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ATX Code G03XA01 Danazol
Active substance: Danazol
Pharmacological group
Hormone Hypothalamus, Hypophyse, Gonadotropin und deren Antagonisten
Nosological classification (ICD-10)
E30.1 Premature puberty
Premature puberty, Premature sexual development, Premature puberty in girls, Early puberty, Primary premature puberty
N60.1 Diffuse cystic mastopathy
Benign cystic change in mammary glands, Cystic fibrosis mastopathy, Fibrous-cystic mastopathy, Pre-cancerous condition of mammary glands, Benign mammary gland disease, Benign breast tumor
N62 Hypertrophy of the breast (breast) gland
Gynecomastia, Hypertrophy of the mammary glands, Macromastia
N80 Endometriosis
Endometrioid endometriosis
N92 Abundant, frequent and irregular menstruation
Metromenorragii, Menorrhagia, Menorrhagia primary, Polymenorea, Idiopathic menorrhagia, Menorrhagia, Functional metronormorragia, Primary menorrhagia
N92.2 Abundant menstruation in the puberty period
N94.3 Premenstrual tension syndrome
Pronounced premenstrual syndrome, Menstrual psychosomatic disorder, Menstrual syndrome, Premenstrual tension, Premenstrual status, Premenstrual period, Premenstrual syndrome, Menstruation syndrome
N96 Habitual miscarriage
Miscarriage habitual, Habitual abortion, Habitual miscarriage
N97 Female infertility
Female infertility in anovulation, Hyperprolactinemic infertility, Hyperprolactinaemia with infertility, Endocrine infertility, Infertility due to hypothalamic-pituitary dysfunction, Infertility infertility, Infertility, Infertility on the background of hyperprolactinaemia, Functional infertility, Marriage is infertile, Infertility of ovarian genesis, Stimulation of the growth of a single follicle
Composition
1 hard capsule contains 100 mg or 200 mg of danazol; In a blister 10 pcs., In a box of 10 blisters.
pharmachologic effect
The pharmacological action is antigonadotropic.
Suppresses the production of pituitary gonadotropic hormones (LH and FSH) in men and women; Oppresses the activity of the ovaries, inhibits ovulation, causes atrophy of the endometrium.
Indication
Endometriosis and the resulting infertility, mastopathy, primary menorrhagia, premature puberty in girls, macromastia, gynecomastia, premenstrual syndrome.
Contraindications
Porphyria.
pregnancy and lactation
Contraindicated. At the time of treatment should stop breastfeeding.
Side effects
Dyspepsia, increased intracranial pressure, dizziness, headache, agitation, seizures, alopecia, fluid retention in the body, weight gain, hot flashes, breast size reduction, liver dysfunction, seborrhea, acne, hirsutism, nausea, nervousness, pain in the body. Back, cramps, cholestatic jaundice.
Interaction
Enhances the effect of anticoagulants and carbamazepine, may increase the need for insulin.
Dosing and Administration
Inside, adults - 200-800 mg 2-4 times a day, the course - 6 months; Children - from 100 to 400 mg / day.
storage Conditions
In a dry place, at a temperature below 25 ° C.
Keep out of the reach of children.
Shelf life
Capsules are solid 100 mg - 5 years.
Capsules are solid 100 mg - 3 years.
Capsules are solid 200 mg - 5 years.
Capsules are solid 200 mg - 3 years.
Do not use after the expiry date printed on the package.