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Instruction for use: Cyanocobalamin

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Trade name of the drug Vitamin B12, Cyanocobalamin, Cyanocobalamin bufus, Cyanocobalamin (Vitamin B12), Cyanocobalamin-Vial, Cyanocobalamin solution for injections, Cicomin-Altfarm

The Latin name of the substance Cyanocobalamin

Cyanocobalaminum (genus. Cyanocobalamini)

Chemical name

Α- (5,6-dimethylbenzimidazolyl) cobalt cyanide

Gross formula

C63H88CoN14O14P

Pharmacological groups:

Vitamins and vitamin-like remedies

Stimulators of hematopoiesis

The nosological classification (ICD-10)

D51 Vitamin-B12-deficiency anemia: Vitamin-B12 deficiency anemia; Macrocytic vitamin-B12-deficiency anemia; Anemic pernitic

D61 Other aplastic anemia: Fanconi anemia; Anemia aplastic

E53.8.0 * Vitamin deficiency: Hypovitaminosis; Deficiency of iron and folic acid in pregnancy; Deficiency of folic acid; An additional source of folic acid during pregnancy; Folate deficiency; Increased need for folic acid; Folinic hypovitaminosis

G12.2 Motor neuron disease: Tropical spastic paraparesis; Amyotrophic lateral sclerosis; Bulbar Pallas; Bulbar palsy; Amyotrophic lateral sclerosis; Diseases of motor neurons; Amyotrophic lateral sclerosis; Low-Gehrig's disease;Charcot's disease; Amyotrophic amyotrophic sclerosis; Sclerosis lateral primary; Progressive pseudobulbar palsy; Progressive bulbar palsy; Primary lateral sclerosis

G35 Multiple Sclerosis: Disseminated Sclerosis; Multiple sclerosis; Recurrent multiple sclerosis; Secondary-progressive multiple sclerosis; Exacerbation of multiple sclerosis; Mixed forms of multiple sclerosis

G50.0 Trigeminal neuralgia: trigeminal neuritis; Painful tic; Idiopathic trigeminal neuralgia; Neuralgia of the trigeminal nerve; Essential neuralgia of the trigeminal nerve; Pain syndrome in trigeminal neuralgia; Painful tic; Trigeminal neuralgia; Neuralgia of the trigeminal nerve

G54.1 Lesions of the lumbosacral plexus: Lumbosacral radiculitis; Neuralgia of radicular origin; Pathology of the spine; Radiculitis of the lumbosacral; Radiculoneuritis

G54.6 The limb phantom syndrome with pain: Phantom pain; Phantom pain; Phantom pains

G62 Other polyneuropathies: Polyneuritis; Polineuropathy; Inflammation of peripheral nerves

G63.2 Diabetic polyneuropathy (E10-E14 + with common fourth sign .4): Diabetic neuropathy; Pain in diabetic polyneuropathy; Diabetic neuropathic ulcer of lower extremities; Diabetic Neuropathy; Diabetic polyneuropathy; Diabetic Neuropathy; Peripheral diabetic polyneuropathy; Polyneuropathy diabetic; Sensory-motor diabetic polyneuropathy; Pain in diabetic neuropathy; Diabetic polyneuropathy; Diabetic polyneuritis; Pain syndrome in diabetic neuropathy

G80 Cerebral Palsy: Cerebral Palsy; Children's cerebral palsy

G95 Other Spinal Cord Diseases: Spinal Cord Diseases

K52 Other non-infectious gastroenteritis and colitis: Syndrome of senile intestine; Sigmoiditis; Non-infectious gastroenteritis; Gastroenterocolitis; Colitis; Colitis nondiscriptional; Colitis noninfectious; Colitis chronic; Colitis chronic non-infectious; Local enteritis; Non-infectious sigmoiditis; Chronic inflammatory diseases of the large intestine; Chronic inflammatory diseases of the small intestine; Chronic enterocolitis; Chronic atrophic gastroenteritis; Chronic gastroenteritis; Chronic colitis; Chronic enterocolitis; Enteritis; Enteritis non-infectious; Enterocolitis chronic non-infectious; Disease of the large intestine

K73 Chronic hepatitis, not elsewhere classified: Inflammatory liver disease; Hepatitis autoimmune; Hepatitis chronic; Infection of the liver; Chronic hepatitis with signs of cholestasis; Chronic reactive hepatitis; Chronic persistent hepatitis; Chronic infectious hepatitis; Chronic active hepatitis; Chronic inflammatory liver disease; Autoimmune Hepatitis; Chronic hepatitis is aggressive

K74 Fibrosis and cirrhosis of the liver: Edematous-ascitic syndrome in cirrhosis; Inflammatory liver disease; Pretsirroticheskoe state; Cystic fibrosis of the liver; Cirrhotic and pretsirroticheskoe state; Cirrhosis portal hypertension c; Cirrhosis of the liver with signs of portal hypertension; Cirrhosis of the liver with portal hypertension and edema-ascites syndrome; Cirrhosis of the liver with portal hypertension; Liver cirrhosis with ascites and edema; Liver cirrhosis with ascites; cirrhotic ascites

L13.0 Dermatitis herpetiforme: Dyurlinga disease; Bullous herpetiform dermatitis; Duhring's herpetiform dermatitis; Duhring's dermatitis; Herpetiform dermatitis

L20 Atopic dermatitis: Allergic diseases of the skin; Allergic skin disease noninfectious etiology; Allergic skin disease etiology nemikrobnoy; Allergic skin diseases; Allergic skin lesions; Allergic reactions on the skin; atopic dermatitis; Allergic dermatosis; Allergic diathesis; Allergic itching dermatosis; Allergic skin disease; Allergic skin irritation; allergic Dermatitis; atopic Dermatitis; allergic dermatoses; exudative diathesis; Itchy atopic eczema Itchy allergic dermatosis; Allergic skin disease; Cutaneous allergic reaction to drugs and chemicals; Cutaneous reactions to medications; Skin and allergic disease; Acute eczema; common neurodermatitis; Chronic atopic dermatitis; Exudative diathesis

L40 Psoriasis: Chronic plaque psoriasis with diffuse; generalized psoriasis; Psoriasis of the scalp; hairy parts of the skin; A generalized form of psoriasis; Psoriazoformny dermatitis; Psoriasis complicated with erythroderma; disabling psoriasis; Isolated psoriatic plaque; Eksfolliativny psoriasis; psoriatic erythroderma; Psoriasis with eczematization; Hyperkeratosis in psoriasis; Inverse psoriasis; Psoriasis ekzemopodobnye; dermatoses psoriazoformny; Psoriasis genitals; Psoriasis lesions with hairy areas of the skin; erythrodermic psoriasis; Chronic psoriasis of the scalp; Chronic psoriasis; ordinary psoriasis; refractory psoriasis; Koebner phenomenon; psoriasis

L56 Other acute skin changes caused by ultraviolet radiation: Exposure to UV rays; Acute skin changes caused by ultraviolet radiation; Sun Dermatitis; Photodermatitis; Photodermatosis; Photodermatoses; Dermatitis sunflower

M79.2 Neuralgia and neuritis, unspecified: Pain syndrome with neuralgia; Brachialgia; Occipital and intercostal neuralgia; Neuralgia; Neuralgic pain; Neuralgia of intercostal nerves; Neuralgia of the posterior tibial nerve; Neuritis; Neuritis traumatic; Neurological Pain Syndromes; Neurological contractures with spasms; Acute neuritis; Peripheral neuritis; Post-traumatic neuralgia; Severe pain of a neurogenic nature; Chronic neuritis; Essential neuralgia

Q90 Down's syndrome: Mongolism; Monkey wrinkle; Trisomy 21; Trisomy G; Mosaicism in patients with Down syndrome

CAS Code

68-19-9

Characteristics of the substance Filgrastim

Vitamin B12. Crystalline hygroscopic powder of dark red color, odorless. Difficultly soluble in water, solutions have a red (or pink) color. Prolonged autoclaving, oxidizing or reducing substances (ascorbic acid), salts of heavy metals contribute to inactivation; Quickly destroyed by microflora, so solutions should be preserved in aseptic conditions.

Pharmacology

Mode action - Hematopoietic, metabolic, antianemic, erythropoietic.

Has a high biological activity and participates in carbohydrate, protein, lipid metabolism. It increases tissue regeneration, normalizes hematopoiesis, functions of the liver and nervous system, activates the coagulating system of blood, lowers the cholesterol content in the blood (with atherosclerosis). In the body (mainly in the liver) is converted into a cofactor - cobalt, which is part of numerous enzymes, including. In the composition of reductase, which restores folic acid to tetrahydrofolic. Kobamide participates in the transfer of methyl and other single carbonaceous fragments and is therefore necessary for the formation of deoxyribose and DNA, creatine, methionine, the donor of methyl groups, in the synthesis of lipotropic factor-choline, for the conversion of methylmalonic acid to succinic myelin for the utilization of propionic acid. Promotes the accumulation in erythrocytes of compounds containing sulfhydryl groups, which explains the increase in their tolerance to hemolysis.

Absorption occurs throughout the small intestine (partly in the thick). In the ileum it connects with a special internal factor and becomes inaccessible to the microorganisms of the intestine; Complex in the wall of the small intestine transmits cyanocobalamin to the receptor, which transports it into the cell (receptor activity depends on the structure and function of the mucosa supported by folic acid, and also on the presence of calcium ions and pH of the medium). In the blood, vitamin B12 binds to transcobalamins I and II, which transport it to tissues. Depositing occurs mainly in the liver, from the liver is excreted with bile into the intestine and again absorbed. Elimination occurs mainly by the kidneys.

Application of the substance Cyanocobalamin

Chronic anemia, occurring with a deficiency of vitamin B12 (Addison - Birmera, alimentary macrocytic), in the complex therapy of anemia - iron deficiency, posthemorrhagic, aplastic, caused by toxic substances and drugs, myelosis, traumatic injuries and inflammatory processes of peripheral nerves (wound, radiculoneuritis, neuritis , Neuralgia, causalgia, phantom pain), amyotrophic lateral sclerosis, encephalomyelitis, multiple sclerosis, diabetic neuropathy, cerebral palsy, b Down's disease, skin diseases (psoriasis, photodermatosis, herpetiform dermatitis, neurodermatitis), traumatic bone injuries and conditions after surgical operations on the musculoskeletal system with slowing of bone consolidation, acute and chronic hepatitis, cirrhosis, radiation sickness. With the preventive purpose - with the appointment of biguanides, paraaminosalicylic acid, high doses of vitamin C, with pathology of the stomach and intestines, which prevents normal absorption of the vitamin (resection of part of the stomach, small intestine, Crohn's disease, celiac disease, sprue).

Contraindications

Hypersensitivity, hypercoagulation (including with acute thrombosis), erythremia, erythrocytosis.

Restrictions on the use

With caution and in smaller doses prescribed for angina pectoris, benign and malignant neoplasms (used only in cases accompanied by megaloblastic anemia and vitamin B12 deficiency).

Side effects of the substance Cyanocobalamin

Headache, dizziness, agitation, pain in the heart, tachycardia, allergic reactions (urticaria).

Interaction

Pharmaceutically (in one syringe) is incompatible with solutions of vitamins, B1 and B6 (cobalt ion contributes to the destruction of other vitamins). Increases the likelihood of allergic reactions caused by vitamin B1.

Routes of administration

Inside, SC, IM, IV and intralumbar.

Precautions for the substance Cyanocobalamin

During the treatment should regularly monitor the picture of blood and clotting.

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