Instruction for use: Bopindolol

Trade name of the drug – Sandonorm

The Latin name of the substance Bopindolol

Bopindololum (genus. Bopindololi)

Chemical rational name: (±) -1 - [(1,1-dimethylethyl) amino] -3 - [(2-methyl-1H-indol-4-yl) oxy] -2-propanol benzoate (ester) (in the form of maleate 1: 1)

Gross formula C23H28N2O3

Pharmacotherapeutic group: Beta-blockers

The nosological classification (ICD-10)

I10 Essential (primary) hypertension: hypertension; Arterial hypertension; Arterial hypertension crisis course; Essential Hypertension; Essential hypertension; Essential hypertension; Essential hypertension; Essential hypertension; Primary hypertension; Arterial hypertension, complications of diabetes; The sudden increase in blood pressure; Hypertensive disorders of blood circulation; hypertensive condition; hypertensive crises; arterial Hypertension; malignant Hypertension; Hypertonic disease; hypertensive crises; accelerated hypertension; malignant hypertension; The aggravation of hypertensive disease; Transient hypertension; Isolated systolic hypertension

I15 Secondary hypertension: Arterial hypertension, complications of diabetes; hypertension; The sudden increase in blood pressure; Hypertensive disorders of blood circulation; hypertensive condition; hypertensive crises; hypertension; arterial Hypertension; malignant Hypertension; hypertensive crises; accelerated hypertension; malignant hypertension; The aggravation of hypertensive disease; Transient hypertension; hypertension; Arterial hypertension; Arterial hypertension crisis course; renovascular hypertension; Hypertension symptomatic; Renal hypertension; Renovascular hypertension; renovascular hypertension; Symptomatic hypertension

I20 Angina [angina]: Heberden disease; Angina pectoris; The attack of angina pectoris; recurrent angina; Spontaneous angina; Stable angina pectoris; Angina rest; Angina progressing; Angina mixed; Angina spontaneous; stable angina; Chronic stable angina; Angina Syndrome X

I49.9 Irregular heartbeat, unspecified: Paroxysmal supraventricular tachycardia; extrasystole arrhythmia; Atrial fibrillation tachysystolic; supraventricular tachyarrhythmia; supraventricular arrhythmias; AV reciprocating tachycardia; AV-nodal reciprocating tachycardia; ventricular fibrillation; Irregular heartbeat; Antidromic reciprocating tachycardia; Cardiac arrhythmias; Arrhythmias; Arrhythmia; Heart arythmy; Arrhythmia due to hypokalemia; ventricular tachyarrhythmias; The high frequency of ventricular contraction; Cardiac arrhythmias; Paroxysmal supraventricular arrhythmia; Paroxysmal supraventricular arrhythmia; Paroxysmal dysrhythmia; Paroxysmal atrial-ventricular rhythm; cardiac arrhythmias; supraventricular tachycardia; tachyarrhythmia; Precordial abnormal pulsation

CAS code 62658-63-3

Pharmacological Properties of Bopindolol

Pharmachologic effect - antianginal, hypotensive, anti-arrhythmic.

Blocks beta1- and beta2-adrenergic receptors, has a moderate intrinsic sympathomimetic and membrane stabilizing activity. Stops central sympathetic impulses, reduces the sensitivity of peripheral tissues to catecholamines, inhibits renin secretion. It inhibits automatism sinoatrial node, reduces the occurrence of ectopic foci. It lowers blood pressure, heart rate, speed of excitation, contractility and myocardial oxygen demand at the physical and emotional stress, inhibits the activity of baroreceptors of the aortic arch, and their reaction to the lowering of blood pressure. It has no effect on lipid metabolism. When ingestion rapidly and completely absorbed. Cmax is reached within 2 hours. After a single dose effect lasts for 24 hours.

Application of the substance Bopindolol

Hypertension, angina, arrhythmia.

Contraindications for Bopindolol

Congestive heart failure, pulmonary heart, bradycardia, AV block II and III level, bronchial asthma, pregnancy, breastfeeding.

Restrictions to application

Diabetes, hyperthyroidism, pheochromocytoma, peripheral circulatory disorders.

Pregnancy and breast-feeding

Contraindicated during pregnancy. At the time of treatment should stop breastfeeding.

Side effect of Bopindolol

Dizziness, headache, weakness, bradycardia, AV block, bronchospasm, and allergic reactions.

Interaction

Enhances cardiodepressive effect of verapamil, the hypoglycemic effect of antidiabetic agents.

Overdose

Symptoms: increased severity of side effects.

Treatment: symptomatic therapy: atropine (0.5-1.0 mg / h) or isoprenaline (in / in infusion of 5 mg / min, slow); in the absence of reaction or the development of heart failure - glucagon (8-10 mg for 1 hour, then, if appropriate in / in infusion of 1-3 mg / hr) under constant monitoring of patients.

Precautions for substance Bopindolol

Against the background of peripheral circulatory disorders are possible paresthesia, cold extremities. In patients with diabetes receiving hypoglycemic agents may mask tachycardia caused by hypoglycemia. When concomitant heart failure prior to treatment is necessary to conduct therapy with cardiac glycosides. Before surgery using general anesthesia for 48 hours is necessary to cancel bopindolol. When pheochromocytoma should not be used without an additional injection of alpha-blockers. Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention.