Instruction for use: Becotide

ATX Code R03BA01 Beclometasone

Active substance: Beclometasone

Pharmacological group

Glucocorticosteroids

Nosological classification (ICD-10)

J45 Asthma

Asthma physical effort, status asthmaticus, Bronchial asthma, Asthma lung flow, Bronchial asthma with obstruction of sputum discharge, Bronchial asthma heavy currents, Bronchial asthma physical effort, hypersecretory asthma, Hormone-dependent form of bronchial asthma, Relief of asthma attacks in bronchial asthma, Non-allergic asthma, nocturnal asthma, Exacerbation of asthma, Asthma attacks, Endogenous forms of asthma, Night asthma, Cough with bronchial asthma

Composition and form of release

Aerosol inhalation dosed 1 dose

Beclometasone dipropionate 50 μg

Auxiliary substances: glycerol; Ethanol is anhydrous; Propellant HFA-134a (norflurane); Does not contain freons

In an inhaler with a metering device with an "Optimizer" 200 doses; In a pack of cardboard 1 inhaler.

pharmachologic effect

Pharmacological action - anti-inflammatory, glucocorticoid.

Pharmacokinetics

Absorption of the drug is slow. Excreted mainly in the form of polar metabolites mainly with feces (35-76% of the administered dose for 96 hours), up to 14% - with urine. In the tissues of light beclometasone, dipropionate is rapidly hydrolyzed to beclometasone monopropionate, which in turn hydrolyses to beclometasone. In the liver, there is also a process of converting beclometasone dipropionate to beclometasone monopropionate and then into polar metabolites.

Clinical Pharmacology

Helps reduce the edema of the epithelium and the secretion of mucus by the bronchial glands, reduces the number of mast cells in the mucous membrane of the bronchi, causes relaxation of the smooth muscles of the bronchi. To achieve effective results, regular admission is necessary. Especially shown to patients who had not previously received steroid therapy (or who received short courses). Patients receiving steroid therapy, starting with the second week of inhalation, oral steroids are gradually canceled.

Indications

Bronchial asthma (including with a decrease in the effectiveness of bronchodilators or their combination with sodium cromoglycate, in patients with severe and hormone-dependent asthma), asthma in children.

Contraindications

Hypersensitivity.

pregnancy and lactation

Perhaps, but one should evaluate the likely benefits and risks.

Side effects

Vomiting of the voice, irritation of the mucous membrane of the throat; Paradoxical bronchospasm, candidiasis of the oral mucosa.

Dosing and Administration

Inhalation. Depending on the severity of the condition and the individual response of the patient, the dose of the drug can be increased or decreased until an optimal effect is obtained. Adults and children over 12 years of age:

- bronchial asthma of mild severity - 200-600 mcg / day in several doses;

- bronchial asthma of moderate severity - 600-1000 mcg / day in several doses;

- severe bronchial asthma - 1000-2000 mcg / day in several doses.

Children 4 years and older - the starting dose, corresponding to the severity of their condition, up to 400 mcg / day in several receptions; The maximum daily dose is not more than 500 μg.

In connection with the preventive orientation of the action of beclometasone dipropionate, its regular administration is necessary even in the absence of symptoms of bronchial asthma. If the effectiveness of bronchodilators short-acting or the number of necessary inhalations decreases, the patient should consult a doctor. If there is difficulty in coordinating the pressure on the inhaler inhaler with inhalation, the drug can be inhaled through a spacer. When treating small children for inhalation of Becotide, it is more convenient to use the spacer Bebihaler.

Overdose

Symptoms: oppression of the function of the hypothalamus - pituitary - adrenal system.

Treatment: inhalation should be continued at the recommended dose, the function of the system is restored after 1-2 days.

Precautionary measures

In patients with impaired function of the adrenal cortex in stressful situations, operations, infections, etc. It is necessary to increase the dosage of inhalations and additionally prescribe steroids orally; After the abolition of oral steroids it is recommended to reduce the dose of inhalations to a maintenance level. The therapeutic effect is weakened if the can is cold. As with the use of all inhaled corticosteroids, special care should be taken when assigning active or slow-onset tuberculosis to patients.

storage Conditions

At a temperature not exceeding 30 ° C.

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.