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Instruction for use: Aprotex

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Dosage form: Lyophilizate for the preparation of a solution for intravenous administration; Solution for infusions

Active substance: Aprotininum


B02AB01 Aprotinin

Pharmacological groups

Inhibitors of fibrinolysis

Ferment and antiferment

Composition and release form

Lyophilizate for the preparation of a solution for intravenous administration 1 vial.

Aprotinin 10000 ATPE (13300 KIE); 100,000 ATRE (133,000 KIE)

Auxiliary substances: lactose; Sodium hydroxide

In a pack of cardboard 1, 5 or 10 bottles.

Pharmachologic effect

Mode of action - Hemostatic, antifibrinolytic, antiproteolytic.

Dosing and Administration

IV by stream injection (slowly, max. 5 ml / min) or drip, only in the "lying" position. Contents 1 . Is dissolved in 2 ml (for a dosage of 10,000 ATPE) or 20 ml (for a dosage of 100,000 ATPE) of an isotonic sodium chloride solution.

Usually adults with bleeding initial dose - 300,000 ATPE (399,000 KIE), then - 140,000 ATRE (186,200 KIE) every 4 hours in / in the stream until normal hemostasis.

For acute pancreatitis, 200,000-300,000 ATPE (266,000-399,000 IUI) IV by stream injection, then - 200,000-300,000 ATPE (266,000-399,000 IUU) / day in / in the drip.

The treatment is carried out until the clinical picture of the disease and the laboratory test results are normalized.

Prevention of postoperative pancreatitis - 200,000 ATPE (266,000 IUI) / day IV by stream injection.

In the case of shock conditions, the initial dose is 200,000-300,000 ATPE (266,000 -399,000 IUU), then 140,000 ATPE (186,000 IUI) iv in every 4 hours.

Children, the daily dose - 14000 ATRE (18620 KIE) / kg.

Patients with pancreatic necrosis and exudate in the abdominal cavity, containing enzymes, aprotinin can be administered additionally intraperitoneally.

Storage conditions of the drug Aprotex

In dry, the dark place at a temperature of 0-20 C.

Keep out of the reach of children.

The shelf life of the drug Aprotex

2 years.

Do not use beyond the expiration date printed on the package.

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