Instruction for use: Antithrombin III

Trade name of the drug – Antithrombine III human

The Latin name of the substance Antithrombin III

Antithrombinum III (genus. Antithrombini III)

Chemical name

glycoprotein (alpha2-glycoprotein with a molecular weight of 58,000) obtained from human plasma

Pharmacological group:

Anticoagulants

The nosological classification (ICD-10)

D65 Disseminated intravascular coagulation [defibrillation syndrome]: DIC syndrome; Intravascular coagulation; Hyperfibrinolytic bleeding; Defibrillation Syndrome; Hyperfibrinolytic bleeding; Hyperfibrinolytic bleeding post-traumatic; Hypocoagulant phase of DIC syndrome; Convolation of intravascular disseminated; The syndrome of disseminated intravascular ; Defibrinization syndrome; Coagulopathies acquired

I74 Embolism and arterial thrombosis: Thrombosis of effort (stress); Arterial thrombosis; Arteriothrombosis; Subacute and chronic arterial thrombosis; Subacute thrombosis of peripheral arteries; Postoperative thrombosis; Vascular thrombosis; Vascular embolism; Thrombosis of aortocoronary shunt; Arterial thrombosis; Thrombosis of arteries; Coronary artery thrombosis; Coronary thrombosis; Thrombosis of blood vessels; Thrombosis with ischemic stroke; Thrombosis with general surgical operations; Thrombosis in Oncology Operations; Vascular thrombosis; Thrombus formation in the postoperative period; Thrombotic complications; Thromboembolic diseases; Thromboembolic syndrome; Thromboembolic complication in the postoperative period; Thromboembolism of arteries; Partial vascular thrombosis; Embolism; Embolism of arteries

I80 Phlebitis and thrombophlebitis: Diseases of peripheral vessels; Inflammation of superficial veins; Inflammatory diseases of veins; Deep venous thrombophlebitis; The disease of veins; Disease of the veins of the lower extremities; Diseases of peripheral vessels; Migrating phlebitis; Insufficiency of veins of lower extremities; Exacerbation of chronic thrombophlebitis; Acute thrombophlebitis; Acute thrombophlebitis of superficial veins; Periphlebitis; Periflebit surface; Superficial inflammation of veins; Surface thrombophlebitis; Surface phlebitis; Thrombophlebitis; Deep vein thrombophlebitis; Thrombophlebitis superficial; Phlebitis; Phlebitis of deep veins; Phlebitis of superficial veins; Phlebopathy; Chronic thrombophlebitis; Endophlebitis

Characteristics of the substance Antithrombin III

Lyophilized powder of purified human plasma antithrombin III. Solutions for injection have a pH of 6.0-7.5.

Pharmacology

Mode action - Anticoagulant.

Inactivates thrombin, forms covalent bonds with it (in a stoichiometric ratio of 1: 1), oppresses the activity of factors IXa, Xa, XIa, XIIa and plasmin.

Application of substance Antithrombin III

Hereditary deficiency of antithrombin III, DIC-syndrome.

Contraindications

Hypersensitivity, children's age (safety and efficacy not established).

Pregnancy and breast-feeding

The action category for fetus by FDA is B.

Side effects of substance Antithrombin III

Dizziness, shortness of breath or shortness of breath, nausea, bad taste in the mouth, chills, colic, chest pain, blurred vision, feeling of bowel overflow, hives, fever, sweating, bruises.

Routes of administration

I.V.

Precautions for substance Antithrombin III

It is recommended to reduce doses of heparin when it is combined with AT-III (prevention of bleeding). During pregnancy, it is prescribed only in case of emergency (safety not established).

Special instructions

Diagnosis of hereditary deficiency of AT-III should be reliably confirmed by an anamnesis of the patient and his relatives.