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Instructions

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Instruction for use: Antilimpholint Kz

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Dosage form: Lyophilizate for the preparation of a solution for infusions

Active substance: Immunoglobulinum antithymocytarum

ATX

L04AA04 Immunoglobulin antimitocyte (rabbit)

Pharmacological group:

Immunodepressants

The nosological classification (ICD-10)

D80-D89 Individual disorders involving the immune mechanism: Immunodeficiency disorders; Immune system disorders

T86 Dying and rejection of transplanted organs and tissues: Transplant disease vs. host; The rejection crisis in organ and tissue transplantation; The crisis of immunological incompatibility in organ transplantation; Incompatibility of tissues; Graft rejection; Graft rejection; Rejection reactions during organ transplantation; Rejection reactions during tissue transplantation; Graft versus host response; Rejection of transplant rejection; Graft-versus-host syndrome; Fabric incompatibility

Composition and release form

1 ampoule with lyophilized powder for the preparation of injections contains the immunoglobulin fraction of the blood serum proteins of goats immunized with human thymus lymphocytes, obtained by fractionation of whey proteins, followed by sterilizing filtration 50 10 mg; In the box 10 pcs.

Pharmachologic effect

Mode of action - Immunosuppressive.

Contains IgG and IgM, which have the activity of antibodies to human lymphocytes. It blocks antigen-sensitive determinants of immunocompetent cells, activates T-suppressors and partially destroys lymphocytes.

Indication of the drug Antilimpholint Kz

Rejection reactions during transplantation of organs and tissues (prevention and cupping), autoimmune diseases.

Contraindications

Hypersensitivity, marked decrease in immunological reactivity, infectious diseases.

Side effects

It is possible to raise the body temperature (up to 37.5-38 C).

Dosing and Administration

IV by drop infusion, at a speed of 20-30 drops per minute. A solution with a concentration of 10 mg / ml is prepared on an isotonic 0.9% solution of sodium chloride or 5% glucose solution.

Prevention of the rejection crisis: 5 mg / kg, 1 injection before surgery and 6 injections at intervals of 3-5 days after transplantation.

Kupirovanie rejection crisis: in a dose of 7-10 mg / kg.

Precautionary measures

To avoid the development of infectious complications it is recommended to combine with antibacterial agents, including. Antibiotics. When there are signs of heterosensitivity to goat protein (pain in muscles and joints, hives, itching), desensitizing therapy with antihistamine drugs or plasmapheresis is recommended.

Storage conditions of the drug Antilimpholint Kz

In a dry, the dark place at a temperature of 5-15 C.

Keep out of the reach of children.

Shelf life of the drug Antilimpholint Kz

2 years.

Do not use after the expiry date printed on the package.

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