Instruction for use: Anopyrin

Active substance Acetylsalicylic acid

ATX code N02BA51 Acetylsalicylic acid in combination with other drugs, except for psycholeptics

Pharmacological groups

NSAIDs - Salicylic acid derivatives in combinations

Nosological classification (ICD-10)

K13.7 Other and unspecified lesions of oral mucosa

Aspirin burn of the oral mucosa, Gum pain when wearing dentures, Inflammation of the mouth, Inflammation of the oral mucosa, Inflammation of the oral mucosa after radiation therapy, Inflammation of the oral mucosa after chemotherapy, Inflammation of the oral mucosa, Inflammation of the mucous membranes of the mouth, Inflammatory diseases of the oral cavity, Inflammatory process of pharynx, Disease of the oral mucosa, Injuries to the oral cavity and larynx, Injuries of the oral mucosa, Trophic diseases of the oral mucosa, Erosive-ulcerative periodontal disease, Erosive-ulcerative lesion of the oral mucosa, Erotic mucous membrane of the oral cavity, Erotic-ulcerative periodontal lesions, Erotic-ulcerative lesions of the oral mucosa, Radio-epileleitis, Irritation from dental prostheses, Irritation of the oral mucosa with dentures and braces, Oral cavity, When wearing dentures

M05 Seropositive rheumatoid arthritis

Rheumatoid arthritis seropositive

M25.5 Pain in the joint

Arthralgia, Pain syndrome in musculo-articular diseases, Pain syndrome in osteoarthritis, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the joints, Soreness of the joints, Soreness of joints in severe physical exertion, Painful inflammatory joint damage, Painful conditions of the musculoskeletal system, Painful joint conditions, Painful traumatic affection of joints, Pain in the musculoskeletal system, Pain in Shoulder Joints, Pain in the joints, Joint pain, Joint pain with injuries, Musculoskeletal pain, Pain with osteoarthritis, Pain in the pathology of the joints, Pain in rheumatoid arthritis, Pain in chronic degenerative bone diseases, Pain in chronic degenerative joint diseases, Bone-joint pain, Joint pain, Arthritic pain of rheumatic origin, Articular pain syndrome, Joint pain, Rheumatic pain, Rheumatic pains

M54.3 Sciatica

Ishialgia, Neuralgia of the sciatic nerve, Sciatic neuritis

M79.1 Myalgia

Myofascial pain syndromes ,Pain syndrome in musculo-articular diseases, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the muscles, Tenderness of muscles, Muscular soreness in severe physical exertion, Painful conditions of the musculoskeletal system, Pain in the musculoskeletal system, Pain in the muscles, Pain at rest, Muscle aches, Muscle pain, Musculoskeletal pain, Myalgia, Muscle pain, Muscle pain at rest, Muscle pain, Muscular pain of non-rheumatic origin, Muscle pain of rheumatic origin, Acute muscle pain, Rheumatic pain, Rheumatic pains, Myofascial syndrome, Fibromyalgia

M79.2 Neurology and neuritis, unspecified

Pain syndrome with neuralgia, Brachialgia, Occipital and intercostal neuralgia, Neuralgia, Neuralgic pain, Neuralgia, Neuralgia of intercostal nerves,Neuralgia of the posterior tibial nerve, Neuritis, Neuritis traumatic, Neuritis, Neurological Pain Syndromes, Neurological contractures with spasms, Acute neuritis, Peripheral neuritis,Post-traumatic neuralgia,Severe pain of a neurogenic nature, Chronic neuritis, Essential neuralgia

R50 Fever of unknown origin

Malignant hyperthermia, Hyperthermia malignant

R51 Headache

Pain in the head, Cephalgia, Pain with sinusitis, Pain in the back of the head, Painful headache, Headache of vasomotor genesis, Headache of vasomotor origin, Headache with vasomotor disorders, Headache, Neurological headache, Serial headache

R52.2 Other constant pain

Pain syndrome, rheumatic origin, Pain at vertebral lesions, Pain in the chamber, Pain for burns, Pain syndrome weak or moderate, Perioperative pain,Moderate to severe pain, Moderately or weakly expressed pain syndrome, Moderate to severe pain, Ear pain of otitis, Neuropathic pain, neuropathic pain

R68.8 Other specified general symptoms and signs

Toxemia

Composition and form of release

1 tablet contains acetylsalicylic acid 400 mg, as well as calcium carbonate 111 mg and glycine 100 mg as buffer substances; in the blister 10 pcs., in the box 1 blister.

pharmachologic effect

Pharmacological action - anti-inflammatory, antipyretic, analgesic, antacid, gastroprotective.

Inactivates cyclooxygenase, disrupts the synthesis of PG (prostaglandins), prostacyclin and thromboxane. This causes a decrease in pyrogenic effects on the centers of thermoregulation and sensitizing on the nerve endings, leading to an increase in pain sensitivity thresholds. Inhibits platelet aggregation (due to inhibition of synthesis of thromboxane A2).

Pharmacokinetics

Well absorbed in the digestive tract. Cmax total salicylate in plasma is achieved after 2 hours. Binding to plasma proteins - 80-90%. Metabolized in the liver, metabolites are excreted in the urine.

Clinical Pharmacology

The application of so-called buffer tablets reduces the likelihood of undesirable reactions from the gastrointestinal tract (gastrointestinal tract).

Indication of Anopyrin

Pain (headache, dental, muscular, articular, lumbar, neuralgia) and febrile conditions, especially with acute respiratory diseases, rheumatism.

Contraindications

Hypersensitivity, hemorrhagic diathesis, surgical interventions associated with significant bleeding, peptic ulcer, bronchial asthma, gout.

Side effects

Dyspeptic phenomena, increased bleeding, hidden bleeding in the gastrointestinal tract, hypochromic anemia, hematopoiesis, papillary necrosis of the kidneys, liver damage, Reye syndrome in children, allergic reactions.

Interaction

Strengthens the effect of indirect anticoagulants, methotrexate, barbiturates, oral hypoglycemic agents, antibiotics, ulcerogenic effects of corticosteroids, pyrazolones, reduces diuretics, blood levels of vitamin C. Anopyrin action increases antacids, substances that acidify urine, anticoagulants, PASK, procaine; reduce - barbiturates, corticosteroids, cholestyramine, substances, alkalinizing urine. Incompatible with alcohol.

Dosing and Administration

Inside, pre-dissolve in a small amount of water - 400-800 mg 2-3 times a day, but not more than 6 g; children from 1 to 6 years - 150-200 mg, from 6 to 15 years - 250-500 mg 3 times a day. With acute rheumatism - 100 mg / kg / day in 5-6 receptions.

Overdose

A typical symptom is hyperventilation (Kussmaul's breathing).

Precautionary measures

With a long appointment, you need to monitor the blood picture and take into account the possibility of latent bleeding.

storage Conditions

In a dry place, at a temperature of 15-25 ° C.

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.