Instruction for use: Aminomethylbenzoic acid

Trade name of the drug – Ambene, Gumbix, Pamba

The Latin name of the substance Aminomethylbenzoic acid

Acidum aminomethylbenzoicum (genus. Acidi aminomethylbenzoici)

Chemical name

1-Carboxy-4-aminomethylbenzene

Gross formula

C8H9NO2

Pharmacological group:

Inhibitors of fibrinolysis

The nosological classification (ICD-10)

D69.3 Idiopathic Thrombocytopenic Purpura: Werlhof's Disease; Idiopathic autoimmune thrombocytopenia; Idiopathic thrombocytopenic purpura of adults; Idiopathic thrombocytopenic purpura in adults; Immune idiopathic thrombocytopenic purpura; Immune thrombocytopenia; Bleeding in patients with thrombocytopenic purpura; Evans Syndrome; Thrombocytopenic purpura; Thrombocytopenia of immune origin; Chronic idiopathic thrombocytopenic purpura; Essential thrombocytopenia; Autoimmune thrombocytopenic purpura in pregnancy; Posttransfusion purpura

D69.6 Thrombocytopenia, unspecified: Hemorrhagic diathesis of thrombocytopenic origin; Hemorrhagic syndrome of thrombocytopenic origin; Idiopathic thrombocythemia; Thrombocytopenia; May-Hegglina anomalies; Hereditary thrombocytopathies; Fever with thrombocytopenia

K92.2 Gastrointestinal bleeding, unspecified: Gastrointestinal and intestinal bleeding; Acute bleeding from the upper gastrointestinal tract; Gastric bleeding; Gastrointestinal bleeding; Intraoperative abdominal bleeding; Intestinal bleeding; Bleeding in the upper part of the digestive tract; Bleeding gastrointestinal; Bleeding from the upper gastrointestinal tract; Bleeding from the digestive tract; Bleeding intraoperative abdominal; Recurrent bleeding in the digestive tract; Diagnosis of bleeding from the small intestine; Ulcer bleeding; Mallory-Weiss syndrome; Recurrent bleeding from peptic ulcers; Bleeding gastric

N93 Other abnormal bleeding from the uterus and vagina: Atonic uterine bleeding; Prolonged menstruation; Blood loss during menstruation; Bleeding from the genitourinary system; Bleeding uterine dysfunctional; Bleeding from the genital tract of organic etiology; Uterine bleeding; Menorrhagia with fibroids; Functional uterine bleeding; Abnormal bleeding from the genitals in women

O67 Labor and delivery, complicated by bleeding during labor, not elsewhere classified

O72 Postpartum hemorrhage: Bleeding in the puerperium; Postpartum bleeding

R04.8 Bleeding from other parts of the respiratory tract

R58 Bleeding, not elsewhere classified: Abdominal apoplexy; Hemorrhagia; Haemorrhage of the esophagus; Hemorrhage; Generalized bleeding; Diffuse bleeding; Diffuse bleeding; Prolonged bleeding; Blood loss; Blood loss during surgical interventions; Bleeding during surgery and in the postoperative period; Bleeding during labor; Bleeding and haemorrhage in hemophilia B; Bleeding from the gums; Bleeding intraoperative abdominal; Bleeding against a background of coumarin anticoagulants; Hepatic hepatitis; Bleeding in hemophilia A; Bleeding at hemophilia A; Bleeding with inhibitory forms of hemophilia A and B; Bleeding due to leukemia; Bleeding in patients with leukemia; Bleeding; Bleeding due to portal hypertension; Bleeding due to hyperfibrinolysis; Drug bleeding; Local bleeding; Local bleeding due to activation of fibrinolysis; Massive blood loss; Acute blood loss; Parenchymal hemorrhage; Hepatic bleeding; Postoperative hemorrhage; Kidney bleeding; Vascular-platelet hemostasis; Traumatic bleeding; Threatening bleeding; Chronic blood loss

T81.0 Bleeding and hematoma complicating the procedure, not elsewhere classified: Bleeding in the postoperative period; Bleeding during transfusion; Bleeding during operations on the brain; Bleeding during surgical interventions; Bleeding after colorectal interventions; Bleeding after prostatectomy; Bleeding during surgery and in the postoperative period; Bleeding due to surgery on the prostate and urinary tract

CAS code

56-91-7

Characteristics of the substance Aminomethylbenzoic acid

White crystalline powder odorless, hardly soluble in water.

Pharmacology

Mode action - Hemostatic, antifibrinolytic.

Inhibits the activators of plasminogen and plasmin, inhibits fibrinolysis. Promotes the stabilization of fibrin and its deposition in the vascular bed, indirectly induces aggregation and adhesion of platelets and erythrocytes.

Application of the substance Aminomethylbenzoic acid

Bleeding due to hyperfibrinolysis: uterine, pulmonary, renal, perioperative; In the hypocoagulant phase of the DIC syndrome, with liver cirrhosis, peptic ulcer of the stomach and duodenum, hemorrhagic syndrome of thrombocytopenic origin.

Contraindications

Thrombophilic conditions accompanied by the development of thromboses and thromboembolism, hypercoagulable phase of DIC syndrome, severe forms of coronary heart disease or brain, chronic renal failure, pregnancy.

Pregnancy and breast-feeding

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects of Aminomethylbenzoic acid

Dizziness, hypertension or hypotension (including orthostatic), nausea, vomiting, diarrhea, catarrhal phenomena from the upper respiratory tract.

Precaution measures

Regular recording of the coagulogram is mandatory. It is necessary to ensure sufficient fluid intake and control over the adequacy of diuresis.