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Nomigren - combined drug, has anti-migraine, antispasmodic analgesic effect.
Ergotamine is an ergot alkaloid, is a partial agonist of serotonin receptors, indiscriminately blocks 5-HT1A-1D receptors. For ergotamine, alpha-adrenergic blocking activity is combined with a pronounced direct vasoconstrictor effect on the smooth musculature of peripheral and cerebral vessels. In this regard, against the background of the action of ergotamine, a tonic effect on periphyric and cerebral vesicles prevails, which is of therapeutic importance in the management of migraine attacks.
Propiphenazone has analgesic effect.
Caffeine accelerates the absorption of ergotamine and enhances its therapeutic effect. Also, caffeine has a tonic effect on the cerebral vessels.
Camilophin exerts an antispasmodic effect, eliminating the initial vasospasm in the prodromal phase of a migraine attack.
Mekloxamine has anticholinergic, antihistamine, moderately sedative and antiemetic effects.
After ingestion, ergotamine is absorbed to a small extent from the gastrointestinal tract.
Bioavailability is low due to intensive metabolism during "primary passage" through the liver.
The main metabolites are secreted through the intestines with bile.
About 4% is excreted by the kidneys with urine unchanged.
The excretion of ergotamine is biphasic. The half-life (T 1/2) in the final phase is -21h.
Caffeine is well absorbed in the intestine (including fat). T 1/2 is about 5 hours. About 10% is excreted by the kidneys in an unchanged form.
After ingestion, about 25% of propiphenazone is metabolized by "primary passage" through the liver, the volume of distribution is 0.4 l / kg, the maximum concentration in the blood plasma is reached within 30-40 minutes. The maximum effect - after 90 minutes, T 1/2 -o2,1-2,4 h, is excreted by the kidneys with urine.
T 1/2 of mecloxamine and kamilofin - 1,5 - 2 h, are excreted by the kidneys with urine.
Acute migraine attacks (including those accompanied by aura) and migraine-like headaches of vascular genesis.
Nomigren should be taken at the very beginning of the attack.
For the first dose, the recommended dose is 1-2 tablets inside, with water, if after 30 minutes, there is no improvement, one or two more pills should be taken.
The maximum daily dose is not more than 4 tablets, the maximum dose within a week is not more than 10 tablets.
The drug is not recommended to be used for a long time: after 7 days of use in cases requiring longer treatment, take a break for 3-4 days.
Do not use the drug to prevent a migraine attack!
Patients taking Nomigren should periodically monitor the blood picture.
With a systematic use of ergotamine-containing drugs, the patient should be advised to strictly adhere to prescribed doses in order to avoid the development of ergotism: spasm of peripheral vessels - loss of sensation, paresthesia, tingling sensation in the extremities, pain in the lower extremities, cyanosis (especially fingers), marked decrease pulsations, as well as violations from the central nervous system - Vertigo, stupor, coma convulsions.
When symptoms such as numbness of the fingertips of the hands or feet, pain in the heart, acceleration or slowing of the heart, the drug should be stopped immediately and consult a doctor.
Impact on the ability to drive vehicles and manage mechanisms
Nomigen can affect the psychophysical capabilities of the patient, especially when taking concomitantly with alcohol or drugs depressing the central nervous system. Do not drive vehicles and work with potentially dangerous mechanisms for 2-3 hours after taking Nomigren.
Important notice- the outer box design may vary before prior notice!
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