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Atenolol (Atenololum, Atenololi) - the drug has an antiarrhythmic, antianginal, hypotensive effects. It has a negative dromotropic, chronotropic, inotropic and batmotroponoe impact.
The hypotensive effect is the influence on the nervous system, decrease the sensitivity of baroreceptors in the aortic arch, decreased activity of the renin-angiotensin system, reduction of the IOC.
The drug lowers systolic and diastolic blood pressure, reduces the IOC CRM.
The drug has no effect on peripheral arterial tone at therapeutic doses.
Antianginal effects provided by reduction of cardiomyocytes in myocardial oxygen demand, which leads to a decrease in heart rate. The drug reduces the heart rate at rest and during physical activity.
Antiarrhythmic and anesthetic agents increase cardiodepressive effects (increased risk of bradycardia, arrhythmia, hypotension, heart failure). Reserpine, methyldopa, clonidine, guanfacine, potentiate cardiac glycosides negative chrono-, Drome and bathmotropic, insulin and other antidiabetic agents - hypoglycemia. NSAIDs, estrogens, sympathomimetics, xanthines weaken hypotensive effect, absorption, increase - sympatholytic, nitroglycerin, hydralazine and other antihypertensive drugs, antacids - slow absorption. Cimetidine inhibits metabolism. Antidepolyarizuyuschih prolongs the effect of muscle relaxants, coumarin anticoagulant effect. Three / tetracyclic antidepressants, antipsychotics, sedatives, hypnotics, and alcohol potentiate CNS depression. Incompatible with MAO inhibitors.
Dosage Atenolol Nycomed set individually. The usual dose for adults - inside, at the beginning of the treatment is 25-50 mg 1 time / day. gradually increase the dose if necessary. Maximum dose: adults at intake - 200 mg / day. in 1 or 2 divided doses.
C Caution should be used atenolol Nycomed diabetes, COPD (including asthma,emphysema), metabolic acidosis, hypoglycemia; allergic reactions in the history of chronic heart failure (compensated), obliterating peripheral arterial disease (intermittent claudication, Raynaud's syndrome), pheochromocytoma, liver failure, chronic renal failure, myasthenia gravis, thyrotoxicosis, depression (including history), psoriasis, during pregnancy, in elderly patients, in pediatric patients (effectiveness and safety have defined). When using atenolol may decrease the production of tear fluid, which is important for patients using contact lenses.
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