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Instructions

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Instruction for use: Acylpyrin

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Dosage form: effervescent tablets

Active substance: Acidum acetylsalicylicum

ATX

N02BA51 Acetylsalicylic acid

Pharmacological groups

NSAID - Salicylic acid derivatives

The nosological classification (ICD-10)

K13.7 Other and unspecified oral white lesion: Aspirin burn of the oral mucosa; Gum pain when wearing dentures; Inflammation of the mouth; Inflammation of the oral mucosa after radiation therapy; Inflammation of the oral mucosa after chemotherapy; Inflammation of the oral mucosa; Inflammation of the mucous membranes of the mouth; Inflammatory diseases of the oral cavity; Inflammatory process of pharynx; Disease of the oral mucosa; Injuries to the oral cavity and larynx; Injuries of the oral mucosa; Trophic diseases of the oral mucosa; Trophic diseases of the oral mucosa; Erosive-ulcerative periodontal disease; Erosive-ulcerative lesion of the oral mucosa; Erotic mucous membrane of the oral cavity; Erotic-ulcerative periodontal lesions; Erosive-ulcerative lesions of the mucous membrane of the oral cavity; Radio-epileleitis; Irritation from dentures; Irritation of the oral mucosa with dentures and braces; Oral cavity; When wearing dentures

M25.5 Pain in the joint: Arthralgia; Pain syndrome in musculo-articular diseases; Pain syndrome in osteoarthritis; Pain syndrome in osteoarthritis; Pain syndrome in acute inflammatory diseases of the musculoskeletal system; Pain syndrome in chronic inflammatory diseases of the musculoskeletal system; Pain in the joints; Soreness of the joints; Soreness of joints in severe physical exertion; Painful inflammatory joint damage; Painful conditions of the musculoskeletal system; Painful joint conditions; Painful traumatic affection of joints; Pain in the musculoskeletal system; Pain in Shoulder Joints; Pain in the joints; Joint pain; Joint pain with injuries; Musculoskeletal pain; Pain with osteoarthritis; Pain in the pathology of the joints; Pain in rheumatoid arthritis; Pain in chronic degenerative bone diseases; Pain in chronic degenerative joint diseases; Bone-joint pain; Joint pain; Arthritic pain of rheumatic origin; Articular pain syndrome; Joint pains; Rheumatic pain

M54.3 Sciatica: Ischialgia; Neuralgia of the sciatic nerve; Sciatic neuritis

M79.1 Myalgia: Myofascial pain syndromes; Pain syndrome in musculo-articular diseases; Pain syndrome in chronic inflammatory diseases of the musculoskeletal system; Pain in the muscles; Tenderness of muscles; Muscular soreness in severe physical exertion; Painful conditions of the musculoskeletal system; Pain in the musculoskeletal system; Pain in the muscles; Pain at rest; Muscle aches; Muscle pain; Musculoskeletal pain; Myalgia; Muscle pain; Muscle pain at rest; Muscle pain; Muscular pain of non-rheumatic origin; Muscle pain of rheumatic origin; Acute muscle pain; Rheumatic pain; Myofascial syndrome; Fibromyalgia

M79.2 Neuralgia and neuritis, unspecified: Pain syndrome with neuralgia; Brachialgia; Occipital and intercostal neuralgia; Neuralgia; Neuralgic pain; Neuralgia of intercostal nerves; Neuralgia of the posterior tibial nerve; Neuritis; Neuritis traumatic; Neurological Pain Syndromes; Neurological contractures with spasms; Acute neuritis; Peripheral neuritis; Post-traumatic neuralgia; Severe pain of a neurogenic nature; Chronic neuritis; Essential neuralgia

R50 Fever of unknown origin: Malignant hyperthermia; Hyperthermia malignant

R51 Headache: pain in the head; cephalgia; Pain in sinusitis; Pain in the neck; Pain headache; Headache vasomotor origin; Headache vasomotor origin; Headache with vasomotor disturbances; Headache; Neurological Headache; Continuous headache

R52.2 Other permanent pain: Pain syndrome of non-rheumatic origin; Pain syndrome with vertebrogenic lesions; Pain syndrome with neuralgia; Pain syndrome with burns; Pain syndrome is mild or moderate; Perioperative pain; Moderate and severe pain; Moderately or mildly expressed pain syndrome; Moderate and severe pain syndrome; Ear pain with otitis; Neuropathic pain

R68.8 Other specified general symptoms and signs: Toxemia

Structure and Composition

1 tablet or 1 effervescent water-soluble tablet contains acetylsalicylic acid 500 mg; In the blister 10 pcs. Or in an aluminum tube with a polyethylene stopper 15 pcs. Respectively, in a cardboard box 1 blister or 1 tube.

Pharmachologic effect

Mode of action - Anti-inflammatory, antipyretic, analgesic.

Inhibits the biosynthesis of PG, which affects the hypothalamic centers of thermoregulation and pain sensitivity. Reduces the algogenic effect of bradykinin. It affects the processes taking place in the inflammatory focus: it reduces the permeability of capillaries, lowers the activity of hyaluronidase, limits the energy supply of the inflammatory process.

Pharmacokinetics

The maximum concentration in the blood is reached after 2 hours after administration. It is excreted mainly with urine, mostly in the form of salicylic acid and its conjugates. T1 / 2 - 2,5-8,5 h - significantly depends on the dose and pH of urine (with a large dose is extended to 16-19 hours).

Indications for Acylpyrin

Pains of various genesis (inflammatory, rheumatic) and localization (head, joint, muscle, dental, back pain, neuralgia, etc.); Hyperthermia in acute respiratory infections of influenza nature.

Contraindications

Hypersensitivity, hemorrhagic diathesis, surgical interventions (associated with significant bleeding), peptic ulcer of the stomach and duodenum, bronchial asthma, gout.

Pregnancy and breast-feeding

During pregnancy (penetrates through the placental barrier) and lactation (enters the mother's milk), only short-term use is permissible.

Side effects

Dyspeptic disorders, latent bleeding (including in the gastrointestinal tract), hypochromic anemia, hematopoiesis disorders, liver damage, kidney parenchyma necrosis, Reye syndrome in children, aspirin asthma, allergic reactions.

Interaction

Strengthens the effect of indirect anticoagulants, methotrexate, barbiturates, oral antidiabetic agents, sulfonamides, penicillins, tetracyclines, corticosteroids and pyrazolones (ulcerogenic), increases plasma levels of antidepressants; Reduces the action of sulfinpyrazone, spironolactone, the level of NSAIDs. Slows down the absorption of histamine and anticholinergics, narcotic analgesics, chloramphenicol, etc. (pauses 2-3 hours between ingestion of these drugs are necessary). Antacids, anticoagulants increase the action of acylpyrine; Barbiturates, corticosteroids, cholestyramine, etc. - weaken. Incompatible with alcohol.

Dosing and Administration

Inside, during or immediately after a meal - 1-2 tablespoons. (Effervescent tablet is recommended to dissolve in a small amount of water) 2-3 times a day (but not more than 6 g / day).

Children are appointed in exceptional cases: from 1 to 6 years - 150-250 mg; From 6 to 15 years - 250-500 mg 3 times a day. In the acute stage of rheumatism - 100 mg / kg / day in 5-6 receptions. Anti-inflammatory doses - 3-6 g / day (for a short time).

Overdose

The main sign of intoxication is hyperventilation (Kussmaul's breathing).

Precautionary measures

With prolonged use, it is necessary to control the cellular composition of the blood and keep in mind the possibility of occult bleeding from the gastrointestinal tract. When prescribed to patients for whom excess sodium ions are contraindicated, the presence of sodium in the effervescent tablets should be taken into account.

Storage conditions of the drug Acylpyrin

In a dark, dry place at a temperature no higher than 25 C.

Keep out of the reach of children.

The shelf life of the drug Acylpyrin

2 years.

Do not use beyond the expiration date printed on the package.

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