Tetrasterone

International name: Testosterone (mixture of esters)

Group accessory: Androgen

Description of active ingredient (MNN): Testosterone [mix of air]

Dosage form: solution for intramuscular introduction [oil]

Pharmacological action: Androgenic means has also anabolic effect. In cages targets (skin, a prostate gland, seed bubbles, epididimus) it is restored 5 - alpha reeducates to 5 - alpha dihydrotestosterone which specifically interacts with membrane receptors on a surface of cages and gets into a kernel. In some fabrics (including in a hypothalamus) turns into estradiol. At men stimulates development and activity of gonads, a prostate gland, seed bubbles, formation of secondary men's signs (growth, a deep voice, growth of a beard and moustaches), raises a libido and a potentiality; indirectly, through TsNS, influences sexual behavior. Reduces adjournment of fat and removal of minerals. Suppresses development and release by a hypophysis of LG and FSG. Has anabolic effects: participates in growth of a skeleton, increases the mass of skeletal muscles; causes a delay of nitrogen, phosphorus, K+, are gray, necessary for protein synthesis. Air of testosterone which is a part of medicine has various speed of absorption and removal that provides fast development of effect and long action (to 4 weeks) after single introduction: testosterone propionate works within the first days, fenilpropionat and isocapronat in 24h after an injection. Please pay attention to Testalamin.

Indications: Men have a replacement therapy at primary and secondary hypogonadism (a puberty delay, hypopituitarism, eunuchoidism, postcastratsion syndrome, oligospermatism); men's climacterium, impotency (impotentia generandi virilis); deficiency of androgens (Addison's illness, adiposagenital syndrome, pituitary nanizm), sterility (at disturbance of spermatogenesis). Women have an osteoporosis (against the background of deficiency of androgens), a breast cancer, ovarian cancer, dysfunctional bleedings at hyperestrogenism, hysteromyoma, an endometriosis, disturbances of climacteric at women (together with estrogens), a premenstrual syndrome, a breast cancer (late metastatic forms), an osteoporosis.

Contraindications: A hypersensitivity, prostate cancer and/or thoracal gland, gynecomastia, nephrosis or a nephrotic stage of nephritis, prostatauxe with ischuria symptoms, a liver/renal failure, hypercalcemia, edemas, HSN, diabetes mellitus, myocardial infarction in the anamnesis, widespread atherosclerosis, pregnancy, the lactemia period. An asthenic body build, advanced age at men; teenage age at boys (before the puberty period).

Side effects: Acne, seborrhea, edemas, allergic reactions, intensifying of a libido, frequent erection, depression of volume of an ejaculate; hypercalcemia; disturbance of a spermatogenesis and maturing of spermatozoons; priapism, premature puberty of boys, augmentation in penis sizes, premature closing of an epiphysis of bones; Na delay + and waters, giddiness, nausea; pain, an itch, a hyperemia in the place of an injection; bleeding from GIT, metrorrhagia, thrombophlebitis, cholestatic icterus, rising of activity of "hepatic" transaminases. At prolonged use at women a virilny syndrome (voice coarsening, excess body height of hair in the face and a body), an atrophy of mammary glands, an amenorrhea.

Overdosage. Symptoms: priapism. Treatment: the termination of therapy before disappearance of symptoms, with the subsequent purpose of smaller doses.

Route of administration and doses: In oil. To men - 100-200 mg of 1 times in 15 days, a course of treatment - 10-15 injections; at an impotency and a menopausal syndrome - 0.1 g of 1 times in 15 days, a course of treatment - 5 injections. To women at a menopausal syndrome prescribe on 0.1 g of 1 times in 2-3 weeks; at a breast cancer and ovaries - 100-200 mg in 1-2 weeks, treatment - long.

Special instructions: For patients with arterial hypertension, migraine, and epilepsy it is necessary during treatment regular medical control.

Interaction: In case of simultaneous application with inductors of enzymes of micro somal oxidation (barbiturates, rifampicin, etc.) decrease in efficiency of testosterone is possible.