Selank - is a synthetic analog of human immunoglobulin G (tetrapeptide tuftsin). It has anxiolytic and neuroprotective effects and used to treat generalized anxiety disorder. Selank is effective in stress reduction, alleviation of depression, reversal of anhedonia, improvement in mood, and cessation of insomnia. Activates the processes of learning, memory, analysis and reproducing information, improves the short-term memory and attention. Selank has no embryotoxic, teratogenic, allergenic and irritating action; doesn't cause drug dependence phenomena.
Selank - a product of the Russian pharmaceutical, synthetic neuropeptide similar in structure to the natural bioregulators of the brain. The only peptide used in medicine tranquilizer. It has no analogues in the world, not only on the structure and functional activity, but also on the release form.
It has a unique, different from all other tranquilizing drugs acting on the central nervous system (CNS), combining the properties of anxiolytic properties with antidepressant effect and antiastenicheskim action and nootropic agents.
Selank absolute bioavailability when administered intranasally is 92.8%. The drug is rapidly absorbed from the nasal mucosa and after 30 seconds is detected in the blood plasma. plasma concentration decreases progressively during 5-5.5 minutes. Metabolites by intranasal route of administration is not detected. It penetrates into the brain tissue. The drug is rapidly distributed to organs and tissues, it is found in unchanged form in the well vaskulyarizirovanngh organs (liver, kidney, heart). The daily urine is not determined by any of unchanged drug or metabolites, that is caused by the rapid degradation under the influence of tissue Selank peptidase.
Burying the drug in the nasal passages of the patient is carried out in a sitting position with his head thrown back a little, and then for a short time, finger pinch each nostril. Suction efficiency may be reduced in the presence of increased excretions of the nasal mucous membrane.
Administered at one time is not more than 2-3 drops into each nostril, that is 300 mg (4 drops - 0.2 mL) -450 mg (6 drops - 0.3 mL). To increase the dose of a single dose of the reintroduction of the drug produced in 15 minutes. The optimal single dose - 300-900 mg (4-12 drops) daily - 900-2700 mg (12-36 drops), distributed into 3 doses during the day. The duration of a course of the drug is 10-14 days. If necessary, treatment can be repeated after 1-3 weeks.
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