Serzone - instructions, dosage, side effects, analogs

Antidepressant: Serzone (Serzone)

Active ingredient: Trazodone (Nefazodone)Analogs: Nefadar

Nefazodone is an antidepressant, chemically similar to trazodone. It affects the re-uptake of norepinephrine and serotonin, increasing their free concentration in the brain.

The drug is well suited for depression, accompanied by increased anxiety, as well as sleep disorders. Notable improvements in patients with such symptoms occur, as a rule, in the first week of nefazodone intake.

The drug has a high degree of safety, usually does not affect weight changes and does not provoke sexual dysfunction. Thus, it is perfectly suitable for long-term therapy.

Indications for use: Treatment of depression of varying severity, also complicated by sleep disorders and increased anxiety.

Contraindications: Do not use concomitantly with MAO inhibitors, until a period of two weeks passes. Also, the manufacturer of an antidepressant is recommended not to take the drug during pregnancy and lactation.

Dosage and administration: Nefazodone should be taken preorally, preferably twice a day, with or without food. As a rule, treatment is started with a minimum dose of 50 mg / day. Take for the night. Further, in the absence of daytime drowsiness and positive tolerability, you should gradually increase the dose to the recommended dose.

The recommended dose varies from 150 to 300 mg twice a day. The maximum dosage is thus 600 mg / day. Very often the dosage is slowly adjusted upwards in order to find the optimal amount of the drug. In this case, if side effects occur, you should wait for them to finish before moving on to a new dosage level. For elderly patients and impaired patients, a reduction in the initial dose, as well as a slower dose change, may be required, but the therapeutic dosage range is consistent with the range for younger patients.

Side effects: Nefazodone can cause the following side effects: nausea, dry mouth, weakness, drowsiness or insomnia, constipation, increased sweating. Most of these effects are observed with a dosage exceeding 300 mg / day.

Storage conditions: Keep away from excessive heat and moisture, out of reach of children and pet at room temperature (below 40 ° C).