Lorazepam - Interactions with other Active Compounds

Lorazepam + Abacavir + Lamivudine + Zidovudine

Metabolism zidovudine (consisting of a combination of abacavir + lamivudine + zidovudine) is carried out mainly in the liver, involving the conjugation reactions, leads to the formation of inactive glucuronide. Lorazepam is the combined use can influence the metabolism of zidovudine (consisting of a combination of abacavir + lamivudine + zidovudine) by competitive binding with glucuronic acid or a direct inhibitory effect on liver microsomal enzymes. Before you assign lorazepam combined with a combination of abacavir + lamivudine + zidovudine, you must carefully weigh the possibility of interaction - especially if you plan long-term treatment.

Lorazepam + Alprazolam

(Mutually) oppression CNS.

Lorazepam + aminophylline

With simultaneous use of aminophylline may reduce the sedative effects of lorazepam.

Lorazepam + Amitriptyline

Lorazepam (mutually) oppression CNS.

Lorazepam + Buprenorphine

(Mutually) oppression CNS.

Lorazepam + Valproic acid

If concomitant use of valproic acid increases the level of lorazepam in plasma.

Lorazepam + Valproic acid

Against the background of valproic acid is enhanced CNS depression, almost twice as decreased Cl and more than twice the rate of glucuronide.

Lorazepam + Haloperidol

Lorazepam (mutually) oppression CNS. You can buy online Haloperidol.

Lorazepam + hydroxyzine

Lorazepam (mutually) oppression CNS.

Lorazepam + guanfacine

(Mutually) sedation.

Lorazepam + Diazepam

It increases the effect. Against the background of / in the introduction of diazepam increases CNS depression and an increased risk of apnea.

diphenhydramine

(Mutually) oppression CNS, may increase the hypnotic effect.

Lorazepam + Zidovudine + lamivudine + nevirapine

Lorazepam with concomitant use of zidovudine (consisting of a combination of lamivudine + zidovudine + nevirapine) modifies the intensity of the biotransformation of zidovudine, which in turn increases the likelihood and frequency of adverse events.

Lorazepam + Zidovudine + lamivudine

Zidovudine (consisting of a combination of zidovudine + lamivudine) is eliminated predominantly by hepatic metabolism to an inactive glucuronide. Lorazepam may alter the metabolism of zidovudine (consisting of a combination of zidovudine + lamivudine) as a result of competitive inhibition of glucuronidation process or direct repression of microsomal metabolism of zidovudine. Before the appointment of lorazepam in conjunction with the combination of zidovudine + lamivudine, especially for long-term treatment, it is necessary to evaluate the possible interaction.

Lorazepam + Zidovudine

If concomitant use of lorazepam with zidovudine may increase the potential toxicity of zidovudine.

Lorazepam + ziprasidone

If concomitant use of lorazepam no clinically significant effect on serum concentrations of ziprasidone.

Lorazepam + Isoniazid

If concomitant use of isoniazid metabolism slows lorazepam and increases its concentration in blood plasma.

Lorazepam + Quetiapine

Average clearance of lorazepam after ingestion of a single dose of 2 mg decreased 20% during quetiapine (250 mg three times a day).

Lorazepam + ketoconazole (ñetoconazole)

The combined application ketoconazole lorazepam metabolism slows down and increases its concentration in blood plasma.

Lorazepam + Clarithromycin + Amoxicillin + lansoprazole

For lorazepam excretion which is independent of the isoenzyme CYP3A, unlikely clinically significant interaction with clarithromycin (consisting of sets of tablets and capsules, lansoprazole + clarithromycin, amoxicillin +).

Lorazepam + Clozapine

If concomitant use of lorazepam with clozapine can be marked sedation, salivation, hypotension, ataxia, delirium, depression and respiratory arrest.

Lorazepam + Clonazepam

The potentiation of CNS depression.

Lorazepam + Metoclopramide

(Mutually) sedation.

Lorazepam + metoprolol

If concomitant use of lorazepam metoprolol slows the metabolism and increases its concentration in blood plasma.

Lorazepam + Milnacipran

No interaction was found with milnacipran lorazepam.

Lorazepam + Moxonidine

Moxonidine is able to moderately improve cognitive impairment in patients receiving lorazepam.

Lorazepam + oxybutynin

Against the background of oxybutynin enhanced hypnotic effect.

Lorazepam + Omeprazole

If concomitant use of omeprazole prolongs the T1 / 2 of lorazepam.

Lorazepam + Omeprazole

Against the background of omeprazole (inhibits CYP450 system) slows the biotransformation and prolonged effect of lorazepam.

Lorazepam + Paroxetine

Against the background of paroxetine dampening effect on the central nervous system.

Lorazepam + pregabalin

When combined pregabalin and lorazepam significant pharmacokinetic interactions were found. Repeated oral administration of pregabalin with lorazepam had no clinically significant effect on respiration. Pregabalin can enhance the effects of lorazepam.

Lorazepam + promethazine

Lorazepam (mutually) oppression CNS; the combined use requires a change in dose.

Lorazepam + Propofol

(Mutually) effects.

Lorazepam + Propranolol

If concomitant use of propranolol increases the level of lorazepam in plasma.

Lorazepam + Risperidone

When used together, care is needed.

Lorazepam + Rifampicin

If concomitant use of rifampicin may enhance the metabolism of lorazepam, and as a result reduce its concentration in the blood plasma.

Lorazepam + Theophylline

With simultaneous application of theophylline (used in low doses) may reduce the sedative effects of lorazepam.

Lorazepam + Topiramate

(Mutually) oppression CNS.

Lorazepam + trazodone

Lorazepam + Tramadol

(Mutually) effect; concomitant use increases the risk of seizures.

Lorazepam + fluvoxamine

Fluvoxamine does not affect the excretion of lorazepam.

Lorazepam + Chlormadinone + Ethinylestradiol

Ethinyl estradiol (as part of a combination of chlormadinone plus ethinylestradiol) may induce glucuronidation in the liver, and the combined use of lower concentrations in the blood plasma of lorazepam.

Lorazepam + cyproheptadine

The combined application of cyproheptadine and lorazepam deprimatsiya mutually amplified and reduced speed of psychomotor reactions.

Lorazepam + ethanol

In an application with alcohol lorazepam in addition gain inhibitory effect on the CNS possible paradoxical reactions (psychomotor agitation, aggressive behavior, state of pathological intoxication).

Lorazepam + Efavirenz

Efavirenz increased lorazepam C max and AUC values of 16.3% and 7.3%, respectively. It is unlikely that these changes are of clinical significance. When combined appointment of efavirenz and correction of their doses of lorazepam is not required.