Notorious Meldonium! aka - Mildronate! Is it that good?

Preparation for supermen, athletes or not?!! What "results" it shows outside of the sports sphere?!!!

Pros of Meldonium: Mildronate invigorates and strengthens the heart muscle.

About scandal with Meldonium now is not heard unless the deaf! Revelation for all was that, it turns out, all of our athletes without exception are ailling!!! And, it turns out, almost all of them are taking Mildronate, a drug that seems like anyone and is not necessary, but why they all drink hard drink, and even hide it !!! So maybe it's a secret that drug for supermen, but we do not know?

Meldonium is a substance from a class S4 Prohibited List of the World Anti-Doping Agency (hormones and modulators of metabolism). The drug is used by athletes to increase endurance and resistance to high physical and neuro-psychological stress.

And I thought at the same time ... "Am I worse than athletes at part loads? Obviously, I can not compare with them by their power load, but because I have the health and stamina not as an athlete .. And my "training" I have enough for the eyes and the ears. Well, tell me the difference between my marathon with 9-12 working day from the marathon distance? Or my life "steeplechase" from the same sport? Call on the "carpet to the boss" can be compared with a boxing ring, and his instructions - a missed puck straight to the teeth. And when I was overtaken by my "menopausal tide" - the race on the Sahara desert may look like just a slight defile on the background of my heart going wild and exhaustion. All agreed - wearing a black trouser suit, holding a press conference / write review and confess over the world - I TAKE MELDONIUM!!!

But, apparently, I'm not one thought so ... While looking at the details of the Mildronate, I has come across interesting information.

The inventor is Professor Ivar Kalvins, director of the Latvian Institute of Organic Synthesis. "Mildronate" was commissioned by the Soviet military, which called on scientists to reduce the mortality rate in Afghanistan from stress and lack of oxygen. Professor Kalvins found a substance (meldonium) in the body which resources are drying up during prolonged stress. The answer was found in the analysis of the works of German physiologists. In 1920 they found a substance that is released after the torture of dogs as a reaction to stress. What horror! (From me) Ivar Kalvins modified molecule so that it does not disappear in the process of metabolism. And the military did everything to strart production of Mildronate.

And for what this Meldonium Mildronate ?

Mildronats is used by patients with coronary heart disease, heart failure, myocardial dystrophy, cerebral circulatory disorders and eye retina, decreasing mental and physical performance, overvoltage.

The drug, which improves metabolism and energy supply of tissues. Meldonium dihydrate is a synthetic analog of gamma-butyrobetaine, a substance that is in every cell of the human body.

Mildronats has a cardioprotective effect, Mildronate 500mg normalizes myocardial metabolism. In acute ischemic myocardial injury meldonium slows the formation of necrotic areas, shorten the rehabilitation period. In heart failure Mildronate injections increases myocardial contractility, increases exercise tolerance, reduces the frequency of angina attacks.

In acute and chronic ischemic cerebrovascular disorders improves blood circulation in the ischemic focus, promotes redistribution of blood to the ischemic area.

Mildronate 500 effective with vascular and dystrophic pathology of the ocular fundus.

Meldonium 500 has a tonic effect on the central nervous system, Mildronate injections eliminate the functional disturbances of somatic and autonomic nervous system in patients with chronic alcoholism during abstinence syndrome.

Yes, indications are above the roof ... and strain / stress, and for the heart and for the fundus (just I have vision problems), and even in the treatment of chronic alcoholism. True - a glass of wine at dinner became suspicious as it is necessary every day !!!

Release forms from Mildronate are different: Mildronats are produced in the form of capsules, tablets and solution for injection.

Mildronate®, 250 mg N40

Mildronate®, 250 mg N60

Mildronate®, 500 mg N60

Mildronate® ampoules 5 ml of 10%

Mildronate® GX, 500 mg (tablets)

Capsules are and very easy to swallow.

Of course, and I opened it up. Inside the capsule - the white crystalline powder, practically odorless and tasteless.

Suggested Use:

Patients with diseases of the cardiovascular system Mildronate tablets and capsules are shown in conjunction with a particular therapy. Meldonium is taken at 500-1000 mg per day. The entire dose can be taken at once, and is divided into two stages. As a rule, the treatment lasts from 4 to 6 weeks.

When cardialgia caused dyshormonal myocardiopathy, Mildronate shoul taken once daily at 500 mg per tablet, or two tablets of 250 mg.

When violations of cerebral circulation after elimination of acute disorders shows the use of meldonium at a dose of 500-1000 mg per day. Take it at once or divided into two reception.

When violations of cerebral circulation in the chronic form is recommended to take 500 mg a day Mildronate.

Athletes Mildronate recommended to be taken twice a day at a dose of 500-1000 mg. The duration of treatment in the preparatory period is 2 to 3 weeks, during the competition duration varies from 10 to 14 days.

When alcohol withdrawal in patients suffering from chronic alcoholism, Mildronat should be taken four times a day 500 mg. Duration of the course - from 7 to 10 days.

The maximum allowable daily dose is considered to be a dose of 2000 mg.Vvidu possible development of stimulating effect Mildronate® recommended in the first half of the day.

Mildronate® desirable to apply to the food, but the efficiency will not change, if we take and after a meal.

Well, since I'm not decided on what exactly I want to take Meldonium and concerns of each group of indications I have little by little from each, I decided to start with the lowest dose of 250 mg / 1 time per day. At the same time check whether I have intolerances or even what that "bad" reaction to the reception. According to one capsule taken five days, I did not see any significant results and moved to receive 2 pcs. per day, i.e. 500 mg / day. Moreover, the impact of the exciting Meldonium also not helped and I took it in the morning and at night. Strengthen larger dose is not considered necessary. All the same, the goal was to use it to a greater extent, to maintain the heart muscle, tortured constant jumps with stress relief, stress, and the desire to "raise" the tone of the whole organism.

Conclusions after treatment by Mildronate - a course of 28 days.

But you know Mildronate is working! After a while, I realized that my real performance and "urge to move" became more. A lot more! Previously, because as - crawled to the house and want somewhere to nestle close to the sofa, I do not want to do anything at all and legs "tough lug around." Even when taking 250 mg I began to notice that "in the body such pleasant flexibility was formed ..." It seems that I physically became easier and gathered, the heart is a little smoother, "wool" disappeared into my head, thinking has become more clear, clear and easy. Sensations in the "brain" is a bit like the feeling in use glycine, Phenotropil or Semax, but here it is expressed more clearly and strongly.

I'm really impressed by Mildronate!!! After a while, I will surely repeat the course.

And finally, another interesting fact about Meldonium:

In Russia, since 2012 Mildronate is on the list VED (Vital and Essential drugs) - the list of drugs whose prices are regulated at the state level, as they should be available to the general public.

Oh, and this is a serious indicator of its "necessity". It should be taken into account. But also to be understood that any drug can bring both benefit and harm, and, ideally, need to coordinate appointment with your doctor, and do not drink and everything indiscriminately and all that. I wrote and I smiled to myself - in our country, it is recommended all the same recommendation, pardon the tautology. We will pass until all these "circles of hell" in the clinics, the heart and grab exactly one have to buy Meldonium.

Meldonium knockdown. AND NOW ... Povetkin

In recent days, Russian sport, one after another got two powerful impact in the stomach. On Thursday evening, the former head of the Moscow Anti-Doping Laboratory Rodchenkov Gregory gave a scandalous interview with New York Times, accusing the three Olympic Sochi 2014 champions - skier Alexander cars, skeletonist Alexander Tretyakov and bobsledder Alexander Zubkov - Used steroid cocktail, which he cooked his own hand. Rodchenkov also claims that the FSB at the Sochi Games in droves substitutes samples of Russian athletes. In total, according to him, about a third of our medalists took illegal drugs.

Yuri Nagorny, Deputy Minister of Sport of the Russian Federation:

- In the West, we are trying to impose a concept of a federal doping programs. We reiterate - no doping program we have been there. Before the Olympics in Sochi, we held only training programs for athletes, but none of its elements does not violate laws and regulations.

Alexander easily, Russian skier, Olympic champion in 2014:

- In preparation for the games we had a very tight control: once the Germans came during a workout, and suddenly asked to give blood and urine. It was in the woods, in unsanitary conditions. I have always complied with all the requirements of the WADA. There were cases when the inspectors arrived at eleven at night, and then took another sample at six in the morning, as if trying to catch me on something. So if I have something to drink, it would be impossible to hide.

Alexander Zubkov, bobsledder, Olympic champion in 2014:

- Why do I need a dope? Especially mixed with alcohol! It's bobsleigh, it is very important reaction and concentration. From my actions depend on the life of the team members. Drink alcohol here it's like to take his racer "Formula 1" before the race. The bobsled best dope - it's a good healthy sleep and the right schedule. My name is dishonored. We, the athletes have to think about how to protect their honor legally. I do not exclude the filing of a lawsuit to Rodchenko for libel.

Yesterday an influential official went even further. Together with the American director Brian Vogel, he published an open letter to the International Olympic Committee and World Anti-Doping Agency, which said that Russia supported doping program at the state level, and urged to double-check a sample of our Olympians.

Finally, on Friday evening, followed by another crushing blow. News agencies reported that the famous Meldonium, which have already begun to slowly forget detected in analyzes of boxer Alexander Povetkin.

Promoter of former world champion Andrew Ryabinsky confirmed the incident. According to him, Povetkin took Meldonium (Mildronate) last year and, accordingly, should fall under the amnesty declared by WADA. In any case, it is hoped that the Russians fight with American Wilder, to be held May 21 at the Ice Palace, still held. But if Povetkin after such a blow can still recover the entire Russian sport is now in a serious knockdown.

Semax: Positive Experience in ophthalmology

Pros of Semax: effective meds, semax clears the brain, improves memory, soothe

Contras of Semax: rather expensive, small jar

I should say, that nasal drops Semax is a quite serious drug. Semax should be used only on a doctor's recommendation. My husband appointed Semax ophthalmologist in complex therapy. Complaints we had a long visual load, fatigue, discomfort in the eyes at night, cramps during the day, and so on - in short.

Besides Semax, we had been prescribed Noopept and Neyromultivit, as well as eye drops emoksipin and kvinax. Well, in the nose, as I said, we were dripping Semax. Support eye flew a lot of money, but the result was worth it - after only 4 days after the start of treatment with Semax eyes did not hurt at all, sleep is deep and calm, nervousness decreased.

So I tell more details about nasal drops Semax - the price of drugs is fairly high.

Semax on the instructions of the ophthalmologist should drip twice a day 2 drops in each nostril. Drip very uncomfortable, sometimes spilled preparation, sometimes poured in large quantities in our noses. About the same and was drip drops Emoxipine. So for such bottles one should keep an eye)).

I know that semaks prescribed to children with delayed speech development, and Semax are actively used by the students during the sessions and people whose work is connected with high intellectual activity. The drug increases efficiency, improves concentration and memory. Treatment time recall with some nostalgia, because in those days, after Semax I slept like a baby deep, wonderful sleep. Drops these nootropic, should be careful with them, ourselves, as some decided not to appoint. We have passed before applying Semax bunch of examinations at a private ophthalmologist clinic. Semax is a high-performance tool. I am sure once a year I will use Semax in combo therapy.

Semax is a Good Medicine

I will tell some words about SEMAX 0.1%. I must say - the drug is not the NZT from "Limitless". If you do not feel any changes then there are 2 options - either you are completely healthy but tired, or bought an old party, or a party that was stored in improper conditions.

After a long course of severe drug treatment, I realized that my memory has left some mental action far from perfect ... and that it was necessary to do something. Because the impending session. To go to a neurologist I just did not have time.

So I decided to spend a couple of hours on the Internet and searching for certain things in style nootropic Express.

I saw Nootropil. But I swept it away immediately, others meds have caused conflicting thoughts. And then this Semax is an intrigued medicine. Although opinion of people are also divided - someone wrote "Wow," someone said "Water". I decided to take a chance and buy Semax, and try Semax by my own.

Later - because the drug has a slight tonic - I decided to take some nose drops. Because Semax is nasal, I should mention that packaging is not convenient and can give surpluses it is not economical. Semax acts almost immediately. I had trouble concentrating - find things became easier. Memory of course is not immediately recovered. But after Semax I come to some sort of normal. And my speech problems also became less.

Buy Riboxin: Say NO to Dyspnea!

Pros of Inosine: activates cell regeneration, Riboxin heals the heart and liver, inexpensive, normalizes metabolism, Riboxin helps with disorders of heart rhythm, improves tissue respiration

Contras of Inosine: possible allergic reaction

Riboxin were highly recommended by my best friend, professional sportsman.

This drug may be appointed for different indications (from the pain in my heart to fetal hypoxia). Inosine improves tissue metabolism! More Riboxin is an anabolic drug - it helps in the formation of the renewal and restoration of cells, muscles and tissues. In this drug no side effects (Inosine very rarely can cause allergies).

Inosine I took on 1 - 2 times per day. I am concerned about shortness of breath (dyspnea) and lack of air. I could not safely climb stairs, gasping for breath at once…

After 7 days of receipt of Inosine, I noticed improvements! After Riboxin I began to sleep peacefully, I felt no shortness of breath!

I can highly recommend Riboxin for every one!!!

Why I was prescribed to take Mildronate?

What kind of tests should one perform before applying it? Indications, contraindications, as well as detailed instructions for use. How to take Mildronate?

Pros of Meldonium: Mildronate facilitates physical activity.

Our whole life depends on how well runs our main motor - heart. More precisely, on how the reduced cardiac muscle cells (cardiomyocytes) whether supplied thereto enough oxygen and nutrients, without which they simply cannot work.

And well, if the original health there is no problem, a man is full of strength and energy, he does not know what a pain in the heart and shortness of breath. Such people will not have any heart disease in their lives for sure.

I have such symptoms at the age of 15, when do physical education classes, I could not run long distances. At the same time with swimming, cycling or cross-country skiing I haven’t had such problems. That is, the symptoms only appeared at long dynamic load on all muscle groups.

On physical examination then all written off to "a growing body" (still do not understand what kind of a diagnosis) on hormonal changes in adolescence, then the lack of regular exercise, and finally, just a lack of desire to run.

I did not complain about the fact that after physical training I had aches in my heart. Well, what complaint could a young girl have on her heart!

I graduated from high school and went to university. Within two years, on the first and second years there was also physical education. All students were divided into three groups depending on the physical preparation and related diseases: basic, preparatory and special. In the main, of course, were the most healthy and strong. In the second - a strong, but not healthy, the presence of chronic diseases has not been canceled in 17-20 years. The third group was weak and sick. But they also had to engage in physical exercise, so as not to die, grinding away at their studies.

I was qualified for a main group. But after a few lessons, I realized that simply can not cope with the loads that give us in the classroom. I found it hard to run along the embankments of the Neva from one bridge to another and to wind a few laps around the Botanical Garden.

During the autumn of clinical examination, I complained about the recurring pain in the hearts for the therapist in the student clinic, on what I had received a meaningful grin in response. Perhaps she, too, thought I was pretending. But during the inspection she found a slight heart murmur, and to soothe her soul, and perhaps my own, she appointed me an electrocardiogram. Well, that was not expensive painless procedure, done quickly, interpretation of the results were available the next day.

I went a couple of days for the ECG, and again I came to the reception to the therapist. This time she was not grinning. She was alert and excited. "Why you had not asked me, as soon as the first sensed that something unpleasant for yourself?" Well, I wonder what the people. I have several years vainly argue people in white coats, I had shortness of breath doing intensive physical activity and there were pains. And then they tell me, where have you been?”

It turned out that the ECG showed myocardial areas, poorly supplied with oxygen, the so-called "moderate ischemic changes." To clarify their reasons had to perform a more thorough investigation - ultrasound of the heart (echocardiography). I was given direction to this study, as well as vitamins and discharged capsule "Mildronate".

I started treatment, but later went to the ultrasound of the heart, which really turned out that some of the blood after the release of it into the aorta comes back to the chambers of the heart (called regurgitation), respectively, the vessels supplying the heart muscle, less blood goes to the power of heart, and hence an insufficient supply of oxygen, i.e. ischemia. This happens due to incomplete closure of the valves of the heart valve, a condition it is congenital or acquired.

In the normal course of life no symptoms do not occur because the body has already adapted to the existing conditions. But with more intensive physical activities just appear all the discomfort, which did not allow me to leave the main group of Physical Education, I was transferred to the preparation group.

In more severe lesions of the aortic valve, and we can talk about the surgical intervention to address this shortcoming. To me nothing is not shown, so you just need to protect heart cells from hypoxia, but at the same time giving a moderate exercise to ensure better performance. And also be tested regularly.

What is "Mildronate" and why it was prescribed to me?

Mildronate is an anti-ischemic drug developed for treatment of heart ischemia and its consequences. Mildronate is used in neurology for the treatment of brain circulation disorders. It significantly improves patients' mood. They become more active, their motor dysfunction decreases, and asthenia, dizziness and nausea become less pronounced.

The active substance of the drug is Meldonium. The action of the drug is to prevent accumulation of cytotoxic intermediate products of fatty acid beta-oxidation in ischemic tissues and to block this highly oxygen-consuming process. Mildronate has a beneficial effect on cerebral circulation disorders and central nervous system functions. Mildronate is prescribed for patients with decreased working efficiency.

Mildronate is available in 250 mg capsules and 500 mg of active ingredient, as well as in injectable form. The capsules are small, they are not difficult to swallow. The capsule shell comprises gelatin white bases, content is a white powder.

The range of indications is quite extensive, but it is understandable. Because the drug is a metabolic means, it simply can not work on the body in only one place locally. The active ingredient is not specific to a particular type of tissue.

As has already been said, I accept "Mildronat" courses for 10 days 2-3 times a year. for several years. Take 2 capsules 2 times a day, then there goes 4 capsules per day.

Additionally, I am no longer tested. Unfortunately, properly evaluate the effect of these drugs is almost impossible. They work at the cellular level and to say how much improved state of the myocardium after a few courses can not be. However, moderate load I bear easily, degradation is not observed, shortness of breath does not appear in the amplification of the load.

When using Mildronate I have never had any feelings, side effects were observed. One can only hope that the active ingredient - Meldonium in the capsule still was somehow affected my body. The only thing that I can say, it's a feeling of "enlightenment in the head." Somehow it was easier to make decisions, I started to respond more quickly to events, improves concentration, the same thing happened when receiving "Phenotropil" or “Semax”, improving thought processes.

Now I am going to buy Mildronate 500 and take another course of Meldonium. May be it really helps?

Pharmacists and athletes about the methods of Meldonium usage

Inventor of Meldonium Latvian professor Ivar Kalvins immediately after speeches WADA said that his Mildronate is not doping. This was confirmed by the chairman of "Biotec" Board of Directors of the holding pharmaceutical Boris Spiegel. He suggested that the agency does not waste time on trifles and after meldonium prohibit athletes vitamin C. «Meldonium - an ordinary Mildronate is the drug that was used in the USSR and now in Russia for patients with coronary heart disease, and to the athletes it has the same attitude as space. This drug is used, even the elderly, when there is a need to support the heart. The ban for use mildronats by athletes - is nothing more than political action. With the same success can be disabled and vitamin C "- Der Spiegel said.

This conspiracy of US pharmacists, who would like to eliminate a rival Russian medicine, an expert in this scandal does not see. Especially because invented in Latvia, the drug was not approved in the United States. "I do not think you can discern a plot of pharmacists who believed Mildronate its competitor. Rather, there is a great policy. Americans simply do not know and do not understand how to eliminate our athletes. "

Many athletes such scandals can cost a career: Athletes are taking different medications - usually in order to maintain health and not have a heart attack at thirty years. How often the same as Maria Sharapova spent three or four hours to forty-degree heat under the scorching sun. Any person in such circumstances need medical support, not to mention the athletes.

Meldonium is used for the treatment of heart disease, as well as to alleviate abstinence syndrome in chronic alcoholism.

Mildronate is intended for complex therapy of heart diseases such as angina pectoris and myocardial infarction, as well as complex therapy of acute and chronic disorders of the brain blood supply. In addition, it is recommended to attenuate mildronats for abstinence syndrome in alcoholism, as well as stimulating agent for the reduced performance and physical stress. The last point meldonium opened the way to the sport, both amateur and professional.

The fact that, as noted in the instructions for use of the drug, under conditions of high load it "restores the balance between delivery and cellular oxygen demand, eliminating the accumulation of toxic products of metabolism in the cells, protecting them from damage and has a tonic effect." As a result of its use of the body acquires the ability to withstand stress and to quickly restore energy reserves that athletes simply priceless.

"Meldonium does not help to run faster and longer." What a dope used Maria Sharapova?

The drug, which is found in the doping trial of Maria Sharapova, you can easily buy in the usual Russian pharmacy.

The fact that mildronate was not developed in a secret laboratory for military or athletes. In 1975, it was created the by Professor Ivar Kalvins, now he heads the Department of Medical Chemistry of the Latvian Institute of Organic Synthesis (Riga).

First mildronat ordered the Defense Ministry, then the Ministry of Health made the drug for medical use. By 2013, Latvia was selling it at EUR 70 million per year - about 0.7% of total exports.

In sports mildronate (or meldonium) are most commonly used in Russia. Last year, when the drug was not banned, it was found in 17% of the doping tests Russian athletes. Among the athletes from other countries the percentage is almost 8 times less - 2.2%.

I contacted the creator of mildronats this morning at 10 Riga time. "I can speak Russian," - said the professor immediately.

How did you created the formula of Mildronate?

- I just wanted to know, what is depleted in the human body by prolonged stress. I found a substance whose biosynthesis resources are depleted is a gamma-butyrobetaine. In the molecule of gamma-butyrobetaine molecule one carbon is replaced by one nitrogen, so it did not decomposed and was useful as a carrier signal from the central nervous system to the periphery of the cells in the reflex. That's all. This is Meldonium.

- What do you feel about fact that Meldronate is banned from 1 January?

- Very Negative. Because if we forbid athletes to take care of health, it is a violation of human rights. No one today with the help of double-blind, randomized clinical trials have not shown that the application of Meldonium improving physical shape, increases stamina, increases power and strength, and so on. There are no papers, so it is an unproven allegations that improves the ability Meldonium or – there is a good English word - performance athlete.

- What does Mildronte do?

- During training, athletes often work to limit or close to the limit of the abilities. If you do it while taking meldonium, athlete's heart is protected from the occurrence of unsafe ischemia or lack of oxygen - after which the cells begin to die. But this does not mean that the athlete because the drug can do something bigger and better than others. Meldonium just protects from the devastating effects of work at full capacity.

Here we have the mayor of Riga Nil Ushakov, he decided that he could run a long distance race on the traditional two days in a row. And what? He almost died. If he would do such thing on the background of Meldonium – most likely, such problems would not exist.

- Nevertheless, World Anti-Doping Agency (WADA) has banned the drug. It is believed that it helps to adapt to stress, increases stamina.

- When you eat proper nutritious food, you will also adapt to increased loads, because you have more energy capacity. There is a list of drugs that proved - at the same steroids will better develop the muscles, with doping, you can show a better result than without it. But this does not apply to Meldonium (Mildronate): when it is used during the competition, he is likely give the opposite effect.

- Why?

- Yes, the athlete will be protected from the harmful effects of ischemia, it will not have a heart attack or stroke, but not run longer or faster than he can. The energy produced from the substrates that are used for this - it is either fat or glucose. Meldonium slows down oxidation of fatty acids, which means that for each gram of substrate brought use less fat. With each gram turns out more than half the energy and blood after all no longer fed. How can you burn something that does not exist?

- But athletes actively used Mildronats - in the Soviet Union, in Russia. May be because it was needed for something?

- The fact that Meldonium was used, I knew. This, in my opinion, is a good decision. They should be used during exercise such drugs. Before the competition, 10 days, probably should not be used to avoid the influence of Mildronate the oxidation of fatty acids. During the competition's okay - if you want, you can risk your health. And during the training necessary to protect the athlete.

To gain a good shape, athletes train hard, and if you suddenly have a problem with the heart and muscles - everything he will perish, he would not be an athlete. Meldonium called - cytoprotector, I.e. protector of cells against the harmful effects of lack of oxygen.

- Then why it was widely used by the military?

- Because when the air lacks oxygen, ischemia occurs or hypoxia. When hypoxia occurs, you have a daze, you can’t shoot either, nor to fly a plane, you need to somehow manage to use all the energy reserves you had. Meldonium activates the utilization of glucose, as a substrate for energy production is more profitable in oxygen consumption.

It turns out energy from each gram less, but requires less oxygen per molecule of ATP produced. It does not improve the performance and capacity of your performance in watts or kilowatts, so to speak. The drug simply allows you to not die when the oxygen deprivation begin. You survive, just with less ability to perform some physical work.

As far as I heard from the military, those who received Meldonium survived in Afghanistan and other mountain areas. And those who did not get Mildronate - well, there's no oxygen, what can you do?

The creator of "Mildronate" intends to make an exception meldonium of WADA list in 2017

"Its pharmacological properties do not match any criteria for defining doping," - said Chairman of the Board "Grindeks" Juris Bundulis.

The manufacturer "Mildronate" drug (active ingredient meldonium) "Grindeks" has addressed an open letter to the World Anti-Doping Agency (WADA), as the company intends to achieve complete elimination of substances from the list of banned from January 1 next year. He told journalists the chairman of "Grindeks" Juris Bundulis.

"We must ensure that from 1 January next year, our preparation was not on the list of banned - said Bundulis -. The managed to convince the WADA, it is not necessary to include meldonium the list of banned and its inclusion was for us unpleasant for a long time to us. surprise. "

"We still have not received any response about the reasons (prohibition meldonium) We decided to open a dialogue on the basis of implementation Us open letter was sent to WADA, the text of which we have provided to the public.." - He stressed.

Bundulis noted that "Mildronat" was not created as doping. "Its pharmacological properties do not match any criteria for defining doping, - he said -. Many countries have recognized it to use."

He believes that the behavior of the leadership of WADA after the meldonium and making preparations containing it, the list of banned substances, away from democracy and the principles of ethics.

"If the president of WADA can afford the words" do not hesitate to contact us, we will reconsider our decision ", it is not democratic, not ethical and open approach - said Bundulis. - There should be an open discussion for the benefit of helping patients and athletes in well. we were puzzled and confused that we meet the argument that we do not understand. "

"Athletes need to buy" Mildronate "

Creator drugs academician Ivars Kalvins said that athletes should use the drug "Mildronate" meldonium containing substance, in order to avoid irreversible changes in the body.

"Athletes should use "Mildronats" to avoid irreversible changes in the body - Kalvins said -. I have a report of St. Petersburg specialists, which clearly says that the sudden death starting at 10 years old I am disappointed by the decision of the WADA, they have no reason to believe that meldonium -. in the doping athlete has rights, including live and pursue a career. "

"There is a clear term in the criteria for performance-enhancing drugs - increase in capacity." Mildronate "does not contribute to strengthening the capacity of the organism" - Kalvins said.

"Among the young athletes to sudden death ten times more than the average for the population. 92% died of sudden death, died during training or competitions. In the US, every third day, and now every other day, a young man dies a sudden death on the playground. We need to help cardiac patients, but (thanks to this assistance), he will not jump up and run on, "-. academician stressed.

"Action of Mildronate for heart is similar to the internal combustion engine principle - we feed the heart, fuel and air and one must correspond to each other stalls the engine...

Our heart is also the engine, but instead of fuels - fatty acids and sugars. And if there is a lack of oxygen, acid does not burn. So, you can restrict their flow. Otherwise, fats are activated to dissolve the cell membrane. This happens when athletes exceed certain limits ", - explained Kalvins.

According to the head of the Laboratory of sports cardiology VPO Russian State University of Physical Culture, Sports, Youth and Tourism Anastasia Mikhailova, about 20% of the athletes are clear signs of over-voltage of the cardiovascular system and the need to apply "Mildronate" or other preparations containing meldonium.

"The signs of overstrain the cardiovascular system are about 20 percent of the athletes, especially in cyclic sports - said Mikhailov -." Mildronate "performed well in this respect, it was a clear positive trend and showed he was not just that 20 percent, but. those who are prone to such problems with the body especially young athletes, passing on an adult level -. their cardiovascular system is unable to cope with the increased loads they can not do without cardioprotection -. heart suffers. "

Meldoniumdopingscandal

Earlier, WADA reported that 140 doping tests of athletes tested positive for meldonium. According to Tass, at least 31 Russian athlete is suspected of the use of prohibited substances. Among them is Maria Sharapova, swimmer Yulia Efimova, skater Paul Pavel Kulizhnikov.

Meldonium substance (drug "Mildronate") is used in sports to improve the endurance of the body to high physical stress during exercise and to high neuro mental stress during the competition. In the CIS countries the drug is used for the prevention of heart disease. The discovery of this substance in the doping sample athlete in competition and Out-from 1 January 2016 qualifies as a violation of anti-doping rules.

Cardionate (Meldonium)

The capsules of 250 mg or 500 mg of meldonium dihydrate (trimethylhydrasine propionate dihydrate); Excipients: potato starch, colloidal silicon dioxide (Aerosil), calcium stearate.

Injection solution 100 mg in 1 ml, in 5 ml ampoules.

Pharmacological Effects are cardioprotective and metabolic.

Pharmacodynamics

The synthetic analogue of gamma-butyrobetaine, inhibits gamma-butyrobetaine hydroxylase, reduces the synthesis of carnitine and transport of long-chain fatty acids across cell membranes, prevents the accumulation in the cells of the activated forms of unoxidized fatty acids - derivatives of acylcarnitine and atsilkofermenta A.

Cardioprotective agent normalizing myocardial metabolism. In conditions of ischemia restores the balance of oxygen delivery process and its consumption in the cells, to prevent violations of transport ATP; simultaneously activates glycolysis, which proceeds without the use of supplemental oxygen. As a result of reducing the concentration of carnitine is synthesized hard gamma-butyrobetaine, which has vasodilating properties. The mechanism of action determines the diversity of its pharmacological effects: increasing efficiency, reducing the symptoms of mental and physical stress, tissue and activation of humoral immunity, cardioprotective effects. In the case of acute ischemic myocardial damage slows the formation of necrotic areas, reduces the rehabilitation period.

In heart failure, increases myocardial contractility, increases exercise tolerance, reduces the frequency of angina attacks. In acute and chronic ischemic cerebrovascular disorders improves blood circulation in the ischemic focus, promotes redistribution of blood to the ischemic area. It is effective in the case of vascular and dystrophic pathology of the ocular fundus. It is also characteristic tonic effect on CSN.

Pharmacokinetics

After intake of rapidly absorbed, bioavailability - 78%, in the blood plasma is reached within 1-2 hours after ingestion. It is metabolized in the body into two major metabolites which the kidneys. Tt 2 when administered depends on the dose, it is 6-8 hours.

Indications:

• Meldonium decreased performance, physical stress (including the athletes), post-operative period to accelerate rehabilitation.
• Meldonium for cardialgia on background dyshormonal myocardial dystrophy, as part of combination therapy of coronary heart disease (angina), congestive heart failure.
• Meldonium for violations of cerebral circulation (stroke, cerebrovascular insufficiency). Additionally for solution for injection.
• Acute circulatory disorder in the retina, hemophthalmus and retinal hemorrhages of different etiologies, thrombosis of the central retinal vein and its branches.

Dosage:

Capsules: inside, swallowing whole with water.

In view of the possible development of stimulating effect it is recommended to use in the morning.

By reducing the health and physical overexertion (including the athletes).

Athletes - 0.5-1 g, 2 times daily before training. The duration of the preparatory period - 14-21 days, during the competition -10-14 days.

Adults - 0.5-1 g 1-2 reception. The course -10-14 days. If you want to receive repeated after 2-3 weeks.

Stable Angina - 0.5-1 g per day in one or two divided doses for the first 3-4 days, then - 2 times a week. The course - 4-6 weeks.

Cardialgia amid dyshormonal myocardial dystrophy - 500 mg per day. The course of treatment - 12 days.

Chronic disorders of cerebral circulation - 0.5 grams per day. The course of treatment - 2-3 weeks.

Injection: intravenous, intramuscular, and retrobulbarno subkonyunktivalno.

Increased physical and mental load: intravenously, 1 ml of 10 times a day. The course - 10-14 days. If necessary, repeat the course in 2-3 weeks.

In cardiovascular diseases (in the complex therapy): iv, 5-10 ml solution for injection (500 mg / 5 ml); a course of treatment - 10-14 days.

Drug interactions

It increases the vasodilatig funds, some antihypertensive drugs, cardiac glycosides.

It can be combined with antianginal drugs, anticoagulants, antiplatelet agents, antiarrhythmics, diuretics, bronchodilators ITIC.

In view of the possible development of mild tachycardia and hypotension should be careful in combination with nitroglycerin, nifedipine, alpha-blockers, antihypertensive agents and peripheral vasodilators.