Diazepam - Interactions with other Active Compounds

Diazepam + Azelastine

Azelastine (mutually) effect on the CNS (central nervous system functioning is deteriorating and decreases the speed of psychomotor reactions).

Diazepam + Alprazolam

Alprazolam (mutually) oppression CNS; in the background in risk / apnea increases in administration of diazepam.

Diazepam + Alprazolam

(Mutually) oppression CNS, increases the risk of apnea (with on / in the introduction).

Diazepam + Amitriptyline

Diazepam (mutually) oppression CNS.

Diazepam + Amprenavir

Amid amprenavir biotransformation blocked increases in blood concentration of diazepam, enhanced activity and toxicity risk.

Diazepam + Atomoxetine

In in vitro studies, atomoxetine did not affect the binding of diazepam to human albumin. Similarly diazepam does not affect the binding to human albumin atomoxetine.

Diazepam + Benzathine benzylpenicillin

Increases free fraction in plasma (has a greater ability to bind to plasma proteins and to displace fixation locations).

Diazepam + Buprenorphine

Buprenorphine (mutually) oppression CNS. Against the background of / in the introduction of diazepam dose should be reduced by at least 1/3 - deepens deprivation and increases the risk of apnea.

Diazepam + Buprenorphine

(Mutually) oppression CNS; simultaneous use can cause respiratory and / or cardiovascular collapse.

Diazepam + Buspirone

Buspirone (mutually) effect; against the background of / in the introduction of diazepam increases CNS depression and an increased risk of apnea.

Diazepam + Buspirone

In a joint application of diazepam and buspirone Nordiazepam level increases and may increase the risk of side effects: dizziness, headache, nausea.

Diazepam + Butorphanol

Butorphanol pharmaceutically incompatible with diazepam.

Diazepam + Sodium valproate

The joint appointment of diazepam and sodium valproate for epilepsy is not possible increase in the frequency and / or severity of seizures grand mal, which may require increased doses of sodium valproate.

Diazepam + Valproic acid

The joint appointment of diazepam and valproic visloty epilepsy it is possible increase in the frequency and / or severity of seizures grand mal, which may require increased doses of valproic acid.

Diazepam + Valproic acid

Against the background of valproic acid nearly doubles the free fraction of blood (shown in healthy volunteers), reduced clearance and Vss.

Diazepam + Venlafaxine

Venlafaxine increases the effect of diazepam.

Diazepam + Haloperidol

Haloperidol (mutually) oppression CNS. Against the background of in / apnea increases the risk of the introduction of diazepam. You can buy online Haloperidol.

Diazepam + Hydroxyzine

Hydroxyzine (mutually) effect; against the background of / in the introduction of diazepam increases CNS depression and an increased risk of apnea.

Diazepam + Hydroxyzine

Diazepam (mutually) oppression CNS; while the appointment of the dose should be reduce by 50% - a high risk of severe, even fatal, complications.

Diazepam + Glipizide

Against the background of diazepam, which has a greater ability to bind to plasma proteins, may increase the effect (hypoglycaemia).

Diazepam + Guanfacine

(Mutually) sedation.

Diazepam + Dexlansoprazol

Noting the absence of clinically significant interactions diazepam with Dexlansoprazol.

Diazepam + Diclofenac + lansoprazole

Lansoprazole (consisting of a combination of Diclofenac + lansoprazole) does not have clinically significant interactions with diazepam.

Diazepam + Disulfiram

Disulfiram may potentiate the sedative effect of diazepam by inhibiting its oxidative metabolism and increase plasma concentrations. Diazepam dosage should be adjusted according to the clinical manifestations.

Diazepam + Diphenhydramine

Against the background of intensified diazepam hypnotic effect of diphenhydramine.

Diazepam + Doxepin

Doxepin diazepam enhances the effect.

Diazepam + Domperidone + Omeprazole

Omeprazole (consisting of a combination of omeprazole + domperidone), being an inhibitor of cytochrome P450, may increase the concentration and reduce the excretion of diazepam (metabolized in the liver by the cytochrome CUR2S19) that in some cases it may require dose reduction.

Diazepam + Droperidol

Droperidol (mutually) oppression CNS. Against the background of in / apnea increases the risk of the introduction of diazepam.

Diazepam + Dutasteride

If concomitant use of dutasteride does not displace diazepam from its association with plasma proteins, and diazepam, in turn, does not displace dutasteride.

Diazepam + Zolpidem

Increases (mutually) effects. Against the background of / in the introduction of diazepam is enhanced CNS depression and the risk of sleep apnea increases.

Diazepam + Isoniazid

Slowing excretion, increases the concentration in the tissues.

Diazepam + Isoflurane

(Mutually) oppression CNS. Against the background of in / apnea increases the risk of the introduction of diazepam.

Diazepam + Interferon alfa

The combined use of alpha interferon in a solution for injection may alter metabolism of diazepam.

Interferon alfa-2b.

Interferon alpha-2b is able to reduce the activity of cytochrome P450 and thus interfere with the metabolism of diazepam.

Diazepam + Itopride

In an application with diazepam itopride change itopride binding protein was observed.

Diazepam + Itraconazole

Itraconazole biotransformation slows and increases the plasma concentration of diazepam (increases and prolongs the sedative and hypnotic effects).

Diazepam + Potassium chloride +Magnesium chloride + Sodium chloride + Sodium fumarate

The combination of potassium chloride, magnesium chloride + + + sodium chloride, sodium fumarate not preclude the designation of diazepam.

Diazepam + Potassium chloride + Sodium acetate + Sodium chloride

The use of a combination of sodium chloride, potassium + sodium acetate + chloride does not prevent the appointment of diazepam.

Diazepam + carbamazepine

Carbamazepine biotransformation stimulates reduces blood concentration and the T1 / 2. The joint appointment of diazepam and carbamazepine for epilepsy it is possible more frequent seizures grand mal, which may necessitate increasing the dose of carbamazepine.

Diazepam + Quetiapine

(Mutually) oppression CNS. Against the background of in / apnea increases the risk of the introduction of diazepam.

Diazepam + Ketamine

While the use of ketamine, diazepam reduces the risk of psychotomimetic symptoms and motor activity, as well as the occurrence of tachycardia and increase blood pressure.

Diazepam + ketoconazole (ņetoconazole)

Ketoconazole biotransformation slows and increases the plasma concentration of diazepam (increases and prolongs the sedative and hypnotic effects).

Diazepam + Clarithromycin + Amoxicillin + lansoprazole

In studies in healthy volunteers have demonstrated that lansoprazole metabolism is performed by cytochrome P450, are not characterized by clinically significant interaction with diazepam also metabolized by the cytochrome P450.

Diazepam + Clozapine

(Mutually) oppression CNS. Against the background of in / apnea increases the risk of the introduction of diazepam.

Diazepam + Clonazepam

(Mutually) oppression CNS, however, with a joint appointment with convulsive disorders may increase the frequency and / or severity of seizures grand mal, which may necessitate increasing the dose of clonazepam.

Diazepam + Codeine

(Mutually) oppression CNS. Against the background of the on / in an increased risk of apnea diazepam, so the dose should be reduced by at least 1/3.

Diazepam + lamotrigine

The joint appointment of lamotrigine and diazepam in epilepsy it is possible increase in the frequency and / or severity of seizures grand mal, which may require increased doses of lamotrigine.

Diazepam + lansoprazole

It does not change (mutually) effect; permissible combined use.

Diazepam + levetiracetam

The joint appointment of diazepam and levetiracetam with epilepsy can not be ruled more frequent seizures grand mal, which may necessitate increasing the dose of levetiracetam.

Diazepam + Levodopa + Entacapone + [Carbidopa]

Perhaps a combination of the combination of levodopa + carbidopa + entacapone with diazepam.

levocabastine *

There was no amplification action of diazepam using conventional dosage levocabastine nasal spray.

Diazepam + Levocetirizine

In the study of the drug interaction of levocetirizine with diazepam clinically significant adverse interactions have been identified.

Diazepam + Linezolid

Linezolid in the form of a solution for infusions pharmaceutically incompatible with diazepam solution.

Diazepam + lorazepam

It increases the effect. Against the background of / in the introduction of diazepam increases CNS depression and an increased risk of apnea.

Diazepam + Methohexital

(Mutually) oppression CNS. Against the background of in / apnea increases the risk of the introduction of diazepam.

Diazepam + Metoclopramide

(Mutually) sedation. Against the background of metoclopramide, accelerates the evacuation of the stomach contents, increased absorption of diazepam.

Diazepam + midazolam

Increases (mutually) effects. Against the background of / in the introduction of diazepam is enhanced CNS depression and the risk of sleep apnea increases.

Diazepam + Mirtazapine

In studies in 12 healthy volunteers, diazepam (15 mg) while the use of mirtazapine (15 mg) has minimal effect on plasma levels of mirtazapine.

However dysmotility caused mirtazapine has been shown to be additive to the called diazepam. Avoid the simultaneous application of diazepam and mirtazapine.

Diazepam + Moclobemide

(Mutually) effect.

Diazepam + Morphine

(Mutually) oppression CNS. Against the background of the on / in an increased risk of apnea diazepam, so the dose should be reduced by at least 1/3.

Diazepam + Naproxen + esomeprazole

Esomeprazole inhibits CYP2C19, and the combined use of esomeprazole (which is part of the combination of naproxen + esomeprazole) 30 mg decreases to 45% clearance of diazepam, CYP2C19 substrate. It is unlikely that this interaction is clinically significant.

You do not need to change the dose of esomeprazole in these cases.

Diazepam + oxazepam

It increases the effect. Against the background of / in the introduction of diazepam increases CNS depression and an increased risk of apnea.

Diazepam + Olanzapine

(Mutually) oppression CNS. Against the background of in / apnea increases the risk of the introduction of diazepam.

Diazepam + Olanzapine

In vivo inhibition was detected olanzapine diazepam metabolism (metabolized mainly isozymes CYP2C19 and CYP3A4).

Diazepam + Omeprazole

As an inhibitor of microsomal oxidation slows elimination of omeprazole and prolongs the effects of diazepam.

Diazepam + Omeprazole

Against the background of omeprazole (inhibitor of microsomal oxidation) slows the biotransformation and prolonged effect of diazepam.

Diazepam + Ornithine

The solutions are incompatible (can not be mixed in the same syringe).

Diazepam + Ornithine

Pharmaceutical incompatibility.

Diazepam + Pantoprazole

Pantoprazole is compatible with the diazepam (metabolized with participation of cytochrome P450 enzyme system).

Diazepam + perphenazine

(Mutually) oppression CNS.

Diazepam + piroxicam

Against the backdrop of increasing the concentration of piroxicam free fraction in plasma (displaced from its association with proteins) may increase the risk of toxic effects.

Diazepam + pramipexole

Sedative effect; the sharing of caution.

Diazepam + primidone

The joint appointment of diazepam and primidone epilepsy can not be ruled more frequent seizures grand mal, which may necessitate increasing the dose of primidone.

Diazepam + procarbazine

Procarbazine diazepam enhances the effect.

Diazepam + promethazine

(Mutually) oppression CNS.

Diazepam + promethazine

Diazepam intensifies and prolongs the (mutually) sedation; with a joint appointment must be to reduce the dose.

Diazepam + Propofol

(Mutually) oppression CNS. Against the background of in / apnea increases the risk of the introduction of diazepam.

Diazepam + Propofol

Diazepam increases the anesthetic and sedation (mutually) effects; combined with the appointment of possible distinct reduction in systolic, diastolic, and mean arterial pressure and cardiac output.

Diazepam + Pegaspargaza

Against pegaspargazy increased free fraction of plasma concentration (displaced from its association with proteins) and can amplify the effect.

Diazepam + Ranitidine

On the background of slowing biotransformation ranitidine and diazepam can amplify the effect.

Milk thistle fruit extract

The combined application of milk thistle fruit extract that inhibits the cytochrome P450 system, can enhance the effect of diazepam.

Diazepam + remifentanil

(Mutually) oppression CNS. Against the background of the on / in an increased risk of apnea diazepam, so the dose should be reduced by at least 1/3.

Diazepam + rivastigmine

In healthy volunteers, there was no evidence of pharmacokinetic interaction between rivastigmine with diazepam.

Diazepam + Risperidone

(Mutually) oppression CNS. Against the background of in / apnea increases the risk of the introduction of diazepam; the sharing of caution.

Diazepam + Risperidone

(Mutually) effect; the sharing of caution.

Diazepam + Rifampicin

Inducing microsomal enzyme system accelerates biotransformation, reduces the blood concentration and T1 / 2.

Diazepam + rifapentine

Rifapentine may enhance the metabolism and reduce the activity of diazepam; while the use of rifapentine may require dose adjustment of diazepam.

Diazepam + Rocuronium

Established pharmaceutical incompatibility with rocuronium solutions containing diazepam.

Sertraline *

Sertraline is bound to plasma proteins. It is therefore necessary to consider the possibility of its interaction with diazepam binding to proteins, although studies have not been conducted noted any interaction. Concomitant use of sertraline and diazepam should be undertaken with caution.

Diazepam + Tamsulosin + Finasteride [set]

In vitro diazepam does not change the content of tamsulosin free fraction (consisting of sets of tamsulosin capsules + finasteride tablets) in human plasma. Also tamsulosin (as part of a set of tamsulosin capsules + finasteride tablets) does not change the content of the free fraction of diazepam.

Diazepam + Temazepam

Increases (mutually) effects. Against the background of / in the introduction of diazepam is enhanced CNS depression and the risk of sleep apnea increases.

Diazepam + Tigecycline

When applying through the T-shaped catheter Tigecycline is incompatible with diazepam.

Diazepam + thioridazine

(Mutually) oppression CNS.

Diazepam + Topiramate

(Mutually) oppression CNS. The joint appointment of diazepam and topiramate in epilepsy it is possible more frequent seizures grand mal, which may necessitate increasing the dose of topiramate.

Diazepam + trazodone

(Mutually) effect; the combined appointment increases the risk of seizures (can not mix solutions, administered in the same syringe).

Diazepam + Tramadol

(Mutually) effect; the combined appointment increases the risk of seizures (can not mix solutions, administered in the same syringe).

Diazepam + Tranexamic acid

The solutions are not compatible.

Diazepam + trifluoperazine

(Mutually) oppression CNS.

Diazepam + fabomotizole

Fabomotizole causes increased anxiolytic action of diazepam.

Diazepam + famotidine

On the background of slowing famotidine biotransformation of diazepam.

Diazepam + phenytoin

The joint appointment of diazepam and phenytoin for epilepsy is possible more frequent seizures grand mal, which may necessitate increasing the dose of phenytoin.

Diazepam + Phenobarbital

Against the background of in / apnea increases the risk of the introduction of diazepam. (Mutually) oppression CNS, however, with a joint appointment in epilepsy is not excluded more frequent seizures grand mal, which may necessitate increasing the dose of phenobarbital.

Diazepam + Phenobarbital

Phenobarbital accelerates the metabolism of diazepam and leads to an acceleration of its elimination. In a joint application with phenobarbital diazepam anticonvulsant effect is enhanced.

Diazepam + Phentanyl

(Mutually) oppression CNS. Against the background of the on / in an increased risk of apnea diazepam, so the dose should be reduced by at least 1/3.

Diazepam + fluvoxamine

Against the background of reduced excretion of fluvoxamine (a danger of accumulation) of diazepam.

Diazepam + Fluoxetine

Concomitant use of diazepam with fluoxetine should be carried out with the minimum therapeutic dose. Application of the minimum therapeutic dose of diazepam is also necessary for 5 weeks after discontinuation of fluoxetine.

With simultaneous use of fluoxetine and diazepam may increase the T1 / 2 of diazepam.

Diazepam + flupirtine

As a result of the interaction in vitro studies flupirtine (has a high degree of association with proteins) with diazepam was found that flupirtine diazepam displaced from binding with plasma proteins, which may lead to increased activity of diazepam.

Diazepam + flurazepam

Increases (mutually) effects. Against the background of / in the introduction of diazepam is enhanced CNS depression and the risk of sleep apnea increases.

Diazepam + fluphenazine

(Mutually) oppression CNS.

Diazepam + fosamprenavir

Fosamprenavir should not be administered simultaneously with a substrate of CYP3A4 diazepam having a narrow therapeutic range of concentrations. The combined use of diazepam and antacids may result in competitive inhibition of the metabolism of diazepam and create the conditions for the existence of life-threatening conditions - prolonged sedation or respiratory suppression function.

Diazepam + chlordiazepoxide

(Mutually) effect. Against the background of in / apnea increases the risk of the introduction of diazepam.

Diazepam + Chlormadinone + Ethinylestradiol

Ethinyl estradiol (as part of a combination of chlormadinone + ethinyl estradiol) may inhibit the activity of hepatic microsomal enzymes, and the combined use increase the concentration of diazepam in blood plasma.

Diazepam + chlorpromazine

(Mutually) oppression CNS.

Diazepam + Chlorprothixenum

(Mutually) oppression CNS. Against the background of / in the introduction of diazepam increases the risk of apnea.

Diazepam + Cetirizine

(Mutually) effect on the CNS (central nervous system functioning is deteriorating and decreases the speed of psychomotor reactions).

Diazepam + Cetirizine

In the study of drug interactions with cetirizine diazepam clinically significant adverse interactions have been identified.

Diazepam + cimetidine

Cimetidine, as an inhibitor of microsomal oxidation, slows the biotransformation, enhances and prolongs the effect.

Diazepam + cyproheptadine

The combined application of cyproheptadine and diazepam is synergistic deprimatsiya and decreases the speed of psychomotor reactions.

Diazepam + ebastine

Ebastine interacts with diazepam.

Diazepam + esomeprazole

The combined use of esomeprazole (inhibitor of CYP2C19) with diazepam (CYP2C19 substrate) may result in higher plasma concentrations of diazepam, which in turn may require reducing the dose. Thus, when co-administered 30 mg of esomeprazole and diazepam diazepam observed decrease in clearance of 45%.

Diazepam + enflurane

(Mutually) oppression CNS. Against the background of in / apnea increases the risk of the introduction of diazepam.

Diazepam + eptifibatide

In clinical studies there was no evidence of pharmacokinetic interaction between eptifibatide and diazepam.

Diazepam + Erythromycin

Slows biotransformation increases the concentration in plasma.

Diazepam + estazolam

(Mutually) oppression CNS. Against the background of in / apnea increases the risk of the introduction of diazepam.

Diazepam + ethanol

(Mutually) oppression CNS.

Diazepam + emoxypine

Emoxypine the combined use enhances the action of diazepam.

Diazepam + ethosuximide

The joint appointment ethosuximide and diazepam in epilepsy and it is possible increase in frequency and / or severity of seizures grand mal, which may require increased doses of ethosuximide.

Diazepam + etravirine

The use of etravirine simultaneously with diazepam can increase the concentration of the latter in plasma.